RNF14

Ring finger protein 14, also known as RNF14, is a human gene.cite web | title = Entrez Gene: RNF14 ring finger protein 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9604| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.cite web | title = Entrez Gene: RNF14 ring finger protein 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9604| accessdate = ]

ee also

* RING finger domain

References

External links

*
*NURSA|C127

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ueki N, Oda T, Kondo M, "et al." |title=Selection system for genes encoding nuclear-targeted proteins. |journal=Nat. Biotechnol. |volume=16 |issue= 13 |pages= 1338–42 |year= 1999 |pmid= 9853615 |doi= 10.1038/4315
*cite journal | author=Kang HY, Yeh S, Fujimoto N, Chang C |title=Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8570–6 |year= 1999 |pmid= 10085091 |doi=
*cite journal | author=Ueki N, Seki N, Yano K, "et al." |title=Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif. |journal=Biochim. Biophys. Acta |volume=1445 |issue= 2 |pages= 232–6 |year= 1999 |pmid= 10320776 |doi=
*cite journal | author=Ito K, Adachi S, Iwakami R, "et al." |title=N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. |journal=Eur. J. Biochem. |volume=268 |issue= 9 |pages= 2725–32 |year= 2001 |pmid= 11322894 |doi=
*cite journal | author=Miyamoto H, Rahman M, Takatera H, "et al." |title=A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4609–17 |year= 2002 |pmid= 11673464 |doi= 10.1074/jbc.M108312200
*cite journal | author=Ueda T, Mawji NR, Bruchovsky N, Sadar MD |title=Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38087–94 |year= 2002 |pmid= 12163482 |doi= 10.1074/jbc.M203313200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=He B, Wilson EM |title=Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 2135–50 |year= 2003 |pmid= 12612084 |doi=
*cite journal | author=Mestayer C, Blanchère M, Jaubert F, "et al." |title=Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines. |journal=Prostate |volume=56 |issue= 3 |pages= 192–200 |year= 2003 |pmid= 12772188 |doi= 10.1002/pros.10229
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Wang L, Hsu CL, Ni J, "et al." |title=Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 2202–13 |year= 2004 |pmid= 14966297 |doi=
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lin DY, Fang HI, Ma AH, "et al." |title=Negative modulation of androgen receptor transcriptional activity by Daxx. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10529–41 |year= 2004 |pmid= 15572661 |doi= 10.1128/MCB.24.24.10529-10541.2004
*cite journal | author=Yang Z, Chang YJ, Miyamoto H, "et al." |title=Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. |journal=Mol. Endocrinol. |volume=21 |issue= 2 |pages= 343–58 |year= 2007 |pmid= 17082327 |doi= 10.1210/me.2006-0104
*cite journal | author=Yang Z, Chang YJ, Miyamoto H, "et al." |title=Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. |journal=Endocrinology |volume=148 |issue= 3 |pages= 1340–9 |year= 2007 |pmid= 17110431 |doi= 10.1210/en.2006-0716
*cite journal | author=Kikuchi H, Uchida C, Hattori T, "et al." |title=ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells. |journal=Carcinogenesis |volume=28 |issue= 8 |pages= 1752–8 |year= 2007 |pmid= 17510080 |doi= 10.1093/carcin/bgm120

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