SPAG6

Sperm associated antigen 6, also known as SPAG6, is a human gene.cite web | title = Entrez Gene: SPAG6 sperm associated antigen 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9576| accessdate = ]

PBB_Summary
section_title =
summary_text = The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.cite web | title = Entrez Gene: SPAG6 sperm associated antigen 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9576| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Diekman AB, Herr JC |title=Sperm antigens and their use in the development of an immunocontraceptive. |journal=Am. J. Reprod. Immunol. |volume=37 |issue= 1 |pages= 111–7 |year= 1997 |pmid= 9138444 |doi=
*cite journal | author=Smith EF, Lefebvre PA |title=The role of central apparatus components in flagellar motility and microtubule assembly. |journal=Cell Motil. Cytoskeleton |volume=38 |issue= 1 |pages= 1–8 |year= 1997 |pmid= 9295136 |doi= 10.1002/(SICI)1097-0169(1997)38:1<1::AID-CM1>3.0.CO;2-C |doilabel=10.1002/(SICI)1097-0169(1997)38:11::AID-CM13.0.CO;2-C
*cite journal | author=Neilson LI, Schneider PA, Van Deerlin PG, "et al." |title=cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus. |journal=Genomics |volume=60 |issue= 3 |pages= 272–80 |year= 1999 |pmid= 10493827 |doi= 10.1006/geno.1999.5914
*cite journal | author=Sapiro R, Tarantino LM, Velazquez F, "et al." |title=Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus. |journal=Biol. Reprod. |volume=62 |issue= 3 |pages= 511–8 |year= 2000 |pmid= 10684790 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Sapiro R, Kostetskii I, Olds-Clarke P, "et al." |title=Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6298–305 |year= 2002 |pmid= 12167721 |doi=
*cite journal | author=Zhang Z, Sapiro R, Kapfhamer D, "et al." |title=A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 7993–8004 |year= 2002 |pmid= 12391165 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ficarro S, Chertihin O, Westbrook VA, "et al." |title=Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11579–89 |year= 2003 |pmid= 12509440 |doi= 10.1074/jbc.M202325200
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139

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