CTBP1

C-terminal binding protein 1, also known as CTBP1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [cite web | title = Entrez Gene: CTBP1 C-terminal binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1487| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chinnadurai G |title=CtBP, an unconventional transcriptional corepressor in development and oncogenesis. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 213–24 |year= 2002 |pmid= 11864595 |doi=
*cite journal | author=Schaeper U, Boyd JM, Verma S, "et al." |title=Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 23 |pages= 10467–71 |year= 1995 |pmid= 7479821 |doi=
*cite journal | author=Boyd JM, Subramanian T, Schaeper U, "et al." |title=A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. |journal=EMBO J. |volume=12 |issue= 2 |pages= 469–78 |year= 1993 |pmid= 8440238 |doi=
*cite journal | author=Katsanis N, Fisher EM |title=A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. |journal=Genomics |volume=47 |issue= 2 |pages= 294–9 |year= 1998 |pmid= 9479502 |doi= 10.1006/geno.1997.5115
*cite journal | author=Schaeper U, Subramanian T, Lim L, "et al." |title=Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8549–52 |year= 1998 |pmid= 9535825 |doi=
*cite journal | author=Sundqvist A, Sollerbrant K, Svensson C |title=The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex. |journal=FEBS Lett. |volume=429 |issue= 2 |pages= 183–8 |year= 1998 |pmid= 9650586 |doi=
*cite journal | author=Fuks F, Milner J, Kouzarides T |title=BRCA2 associates with acetyltransferase activity when bound to P/CAF. |journal=Oncogene |volume=17 |issue= 19 |pages= 2531–4 |year= 1998 |pmid= 9824164 |doi= 10.1038/sj.onc.1202475
*cite journal | author=Sewalt RG, Gunster MJ, van der Vlag J, "et al." |title=C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 777–87 |year= 1999 |pmid= 9858600 |doi=
*cite journal | author=Li S, Chen PL, Subramanian T, "et al." |title=Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11334–8 |year= 1999 |pmid= 10196224 |doi=
*cite journal | author=Postigo AA, Dean DC |title=ZEB represses transcription through interaction with the corepressor CtBP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6683–8 |year= 1999 |pmid= 10359772 |doi=
*cite journal | author=Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B |title=Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3392–403 |year= 1999 |pmid= 10369679 |doi= 10.1093/emboj/18.12.3392
*cite journal | author=Holmes M, Turner J, Fox A, "et al." |title=hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23491–8 |year= 1999 |pmid= 10438528 |doi=
*cite journal | author=Furusawa T, Moribe H, Kondoh H, Higashi Y |title=Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8581–90 |year= 2000 |pmid= 10567582 |doi=
*cite journal | author=Yu X, Baer R |title=Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18541–9 |year= 2000 |pmid= 10764811 |doi= 10.1074/jbc.M909494199
*cite journal | author=Koipally J, Georgopoulos K |title=Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19594–602 |year= 2000 |pmid= 10766745 |doi= 10.1074/jbc.M000254200
*cite journal | author=Melhuish TA, Wotton D |title=The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39762–6 |year= 2001 |pmid= 10995736 |doi= 10.1074/jbc.C000416200
*cite journal | author=Zhang CL, McKinsey TA, Lu JR, Olson EN |title=Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 35–9 |year= 2001 |pmid= 11022042 |doi= 10.1074/jbc.M007364200
*cite journal | author=Izutsu K, Kurokawa M, Imai Y, "et al." |title=The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. |journal=Blood |volume=97 |issue= 9 |pages= 2815–22 |year= 2001 |pmid= 11313276 |doi=
*cite journal | author=Palmer S, Brouillet JP, Kilbey A, "et al." |title=Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25834–40 |year= 2001 |pmid= 11328817 |doi= 10.1074/jbc.M102343200
*cite journal | author=Schuierer M, Hilger-Eversheim K, Dobner T, "et al." |title=Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27944–9 |year= 2001 |pmid= 11373277 |doi= 10.1074/jbc.M100070200

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