CTBP2

C-terminal binding protein 2, also known as CTBP2, is a human gene.cite web | title = Entrez Gene: CTBP2 C-terminal binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1488| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.cite web | title = Entrez Gene: CTBP2 C-terminal binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1488| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chinnadurai G |title=CtBP, an unconventional transcriptional corepressor in development and oncogenesis. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 213–24 |year= 2002 |pmid= 11864595 |doi=
*cite journal | author=Schaeper U, Boyd JM, Verma S, "et al." |title=Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 23 |pages= 10467–71 |year= 1995 |pmid= 7479821 |doi=
*cite journal | author=Katsanis N, Fisher EM |title=A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. |journal=Genomics |volume=47 |issue= 2 |pages= 294–9 |year= 1998 |pmid= 9479502 |doi= 10.1006/geno.1997.5115
*cite journal | author=Turner J, Crossley M |title=Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. |journal=EMBO J. |volume=17 |issue= 17 |pages= 5129–40 |year= 1998 |pmid= 9724649 |doi= 10.1093/emboj/17.17.5129
*cite journal | author=Sewalt RG, Gunster MJ, van der Vlag J, "et al." |title=C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 777–87 |year= 1999 |pmid= 9858600 |doi=
*cite journal | author=Holmes M, Turner J, Fox A, "et al." |title=hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23491–8 |year= 1999 |pmid= 10438528 |doi=
*cite journal | author=Furusawa T, Moribe H, Kondoh H, Higashi Y |title=Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8581–90 |year= 2000 |pmid= 10567582 |doi=
*cite journal | author=van Vliet J, Turner J, Crossley M |title=Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1955–62 |year= 2000 |pmid= 10756197 |doi=
*cite journal | author=Yu X, Baer R |title=Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18541–9 |year= 2000 |pmid= 10764811 |doi= 10.1074/jbc.M909494199
*cite journal | author=Schmitz F, Königstorfer A, Südhof TC |title=RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. |journal=Neuron |volume=28 |issue= 3 |pages= 857–72 |year= 2001 |pmid= 11163272 |doi=
*cite journal | author=Murakami A, Ishida S, Thurlow J, "et al." |title=SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter. |journal=Nucleic Acids Res. |volume=29 |issue= 16 |pages= 3347–55 |year= 2001 |pmid= 11504872 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Turner J, Nicholas H, Bishop D, "et al." |title=The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12786–95 |year= 2003 |pmid= 12556451 |doi= 10.1074/jbc.M300587200
*cite journal | author=Valenta T, Lukas J, Korinek V |title=HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. |journal=Nucleic Acids Res. |volume=31 |issue= 9 |pages= 2369–80 |year= 2003 |pmid= 12711682 |doi=
*cite journal | author=Mirnezami AH, Campbell SJ, Darley M, "et al." |title=Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription. |journal=Curr. Biol. |volume=13 |issue= 14 |pages= 1234–9 |year= 2004 |pmid= 12867035 |doi=
*cite journal | author=Castet A, Boulahtouf A, Versini G, "et al." |title=Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. |journal=Nucleic Acids Res. |volume=32 |issue= 6 |pages= 1957–66 |year= 2004 |pmid= 15060175 |doi= 10.1093/nar/gkh524
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Alpatov R, Munguba GC, Caton P, "et al." |title=Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. |journal=Mol. Cell. Biol. |volume=24 |issue= 23 |pages= 10223–35 |year= 2005 |pmid= 15542832 |doi= 10.1128/MCB.24.23.10223-10235.2004

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes