NCOA4

Nuclear receptor coactivator 4
Identifiers
Symbols	NCOA4; ARA70; DKFZp762E1112; ELE1; PTC3; RFG
External IDs	OMIM: 601984 MGI: 1350932 HomoloGene: 38052 GeneCards: NCOA4 Gene
Gene Ontology Molecular function • transcription coactivator activity • protein binding • androgen receptor binding Cellular component • nucleus Biological process • male gonad development • androgen receptor signaling pathway • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8031	27057
Ensembl	ENSG00000138293	ENSMUSG00000056234
UniProt	Q13772	n/a
RefSeq (mRNA)	NM_001145260.1	NM_001033988
RefSeq (protein)	NP_001138732.1	NP_001029160
Location (UCSC)	Chr 10: 51.57 – 51.59 Mb	Chr 14: 32.97 – 32.99 Mb
PubMed search	[1]	[2]

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.^[1][2][3]

Interactions

NCOA4 has been shown to interact with Peroxisome proliferator-activated receptor gamma^[4] and Androgen receptor.^{[2][5][6][7][8][9][10][11][12]}

See also

• Transcription coregulator

References

1. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261. 
2. ^ ^{a b} Yeh S, Chang C (July 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39278. 
3. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031. 
4. ^ Heinlein, C A; Ting H J, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J. Biol. Chem. (UNITED STATES) 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. ISSN 0021-9258. PMID 10347167. 
5. ^ Alen, P; Claessens F, Schoenmakers E, Swinnen J V, Verhoeven G, Rombauts W, Peeters B (January1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Mol. Endocrinol. (UNITED STATES) 13 (1): 117–28. doi:10.1210/me.13.1.117. ISSN 0888-8809. PMID 9892017. 
6. ^ Miyamoto, H; Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. ISSN 0027-8424. PMC 22623. PMID 9636157. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22623. 
7. ^ Lin, H K; Yeh S, Kang H Y, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (13): 7200–5. doi:10.1073/pnas.121173298. ISSN 0027-8424. PMC 34646. PMID 11404460. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34646. 
8. ^ Yeh, S; Lin H K, Kang H Y, Thin T H, Lin M F, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. ISSN 0027-8424. PMC 21881. PMID 10318905. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21881. 
9. ^ Zhou, Zhong-xun; He Bin, Hall Susan H, Wilson Elizabeth M, French Frank S (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Mol. Endocrinol. (United States) 16 (2): 287–300. doi:10.1210/me.16.2.287. ISSN 0888-8809. PMID 11818501. 
10. ^ He, Bin; Minges John T, Lee Lori W, Wilson Elizabeth M (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. (United States) 277 (12): 10226–35. doi:10.1074/jbc.M111975200. ISSN 0021-9258. PMID 11779876. 
11. ^ Gao, T; Brantley K, Bolu E, McPhaul M J (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Mol. Endocrinol. (UNITED STATES) 13 (10): 1645–56. doi:10.1210/me.13.10.1645. ISSN 0888-8809. PMID 10517667. 
12. ^ He, Bin; Wilson Elizabeth M (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. (United States) 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. ISSN 0270-7306. PMC 149467. PMID 12612084. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149467. 

External links

• NURSA C92

Further reading

• Minoletti F, Butti MG, Coronelli S, et al. (1995). "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2.". Genes Chromosomes Cancer 11 (1): 51–7. doi:10.1002/gcc.2870110108. PMID 7529046. 
• Jhiang SM, Smanik PA, Mazzaferri EL (1994). "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma.". Cancer Lett. 78 (1-3): 69–76. doi:10.1016/0304-3835(94)90033-7. PMID 8180971. 
• Bongarzone I, Butti MG, Coronelli S, et al. (1994). "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.". Cancer Res. 54 (11): 2979–85. PMID 8187085. 
• Bongarzone I, Butti MG, Fugazzola L, et al. (1997). "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.". Genomics 42 (2): 252–9. doi:10.1006/geno.1997.4685. PMID 9192845. 
• Miyamoto H, Yeh S, Wilding G, Chang C (1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22623. 
• Alen P, Claessens F, Schoenmakers E, et al. (1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform.". Mol. Endocrinol. 13 (1): 117–28. doi:10.1210/me.13.1.117. PMID 9892017. 
• Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.". J. Biol. Chem. 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091. 
• Yeh S, Lin HK, Kang HY, et al. (1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21881. 
• Heinlein CA, Ting HJ, Yeh S, Chang C (1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma.". J. Biol. Chem. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167. 
• Gao T, Brantley K, Bolu E, McPhaul MJ (1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays.". Mol. Endocrinol. 13 (10): 1645–56. doi:10.1210/me.13.10.1645. PMID 10517667. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732. 
• Lin HK, Yeh S, Kang HY, Chang C (2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34646. 
• Basolo F, Giannini R, Monaco C, et al. (2002). "Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.". Am. J. Pathol. 160 (1): 247–54. doi:10.1016/S0002-9440(10)64368-4. PMC 1867131. PMID 11786418. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1867131. 
• Zhou ZX, He B, Hall SH, et al. (2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR).". Mol. Endocrinol. 16 (2): 287–300. doi:10.1210/me.16.2.287. PMID 11818501. 
• Thin TH, Kim E, Yeh S, et al. (2002). "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation.". J. Biol. Chem. 277 (39): 36499–508. doi:10.1074/jbc.M202824200. PMID 12068007. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.