SIN3A

SIN3 homolog A, transcription regulator (yeast), also known as SIN3A, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [cite web | title = Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25942| accessdate = ]

ee also

* Transcription coregulator

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401–14 |year= 2003 |pmid= 12943729 |doi=
*cite journal | author=Halleck MS, Pownall S, Harder KW, "et al." |title=A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. |journal=Genomics |volume=26 |issue= 2 |pages= 403–6 |year= 1995 |pmid= 7601471 |doi=
*cite journal | author=Ayer DE, Lawrence QA, Eisenman RN |title=Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. |journal=Cell |volume=80 |issue= 5 |pages= 767–76 |year= 1995 |pmid= 7889570 |doi=
*cite journal | author=Hurlin PJ, Quéva C, Koskinen PJ, "et al." |title=Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5646–59 |year= 1996 |pmid= 8521822 |doi=
*cite journal | author=Hassig CA, Fleischer TC, Billin AN, "et al." |title=Histone deacetylase activity is required for full transcriptional repression by mSin3A. |journal=Cell |volume=89 |issue= 3 |pages= 341–7 |year= 1997 |pmid= 9150133 |doi=
*cite journal | author=Laherty CD, Yang WM, Sun JM, "et al." |title=Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. |journal=Cell |volume=89 |issue= 3 |pages= 349–56 |year= 1997 |pmid= 9150134 |doi=
*cite journal | author=Zhang Y, Iratni R, Erdjument-Bromage H, "et al." |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. |journal=Cell |volume=89 |issue= 3 |pages= 357–64 |year= 1997 |pmid= 9150135 |doi=
*cite journal | author=Meroni G, Reymond A, Alcalay M, "et al." |title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2892–906 |year= 1997 |pmid= 9184233 |doi= 10.1093/emboj/16.10.2892
*cite journal | author=Lin RJ, Nagy L, Inoue S, "et al." |title=Role of the histone deacetylase complex in acute promyelocytic leukaemia. |journal=Nature |volume=391 |issue= 6669 |pages= 811–4 |year= 1998 |pmid= 9486654 |doi= 10.1038/35895
*cite journal | author=David G, Alland L, Hong SH, "et al." |title=Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. |journal=Oncogene |volume=16 |issue= 19 |pages= 2549–56 |year= 1998 |pmid= 9627120 |doi= 10.1038/sj.onc.1202043
*cite journal | author=Wong CW, Privalsky ML |title=Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27695–702 |year= 1998 |pmid= 9765306 |doi=
*cite journal | author=Zhang Y, LeRoy G, Seelig HP, "et al." |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279–89 |year= 1998 |pmid= 9790534 |doi=
*cite journal | author=Tong JK, Hassig CA, Schnitzler GR, "et al." |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917–21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699
*cite journal | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090–100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090
*cite journal | author=Boutell JM, Thomas P, Neal JW, "et al." |title=Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1647–55 |year= 2000 |pmid= 10441327 |doi=
*cite journal | author=Zhang Y, Ng HH, Erdjument-Bromage H, "et al." |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924–35 |year= 1999 |pmid= 10444591 |doi=
*cite journal | author=Kao HY, Downes M, Ordentlich P, Evans RM |title=Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. |journal=Genes Dev. |volume=14 |issue= 1 |pages= 55–66 |year= 2000 |pmid= 10640276 |doi=
*cite journal | author=Huang S, Brandt SJ |title=mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2248–59 |year= 2000 |pmid= 10688671 |doi=
*cite journal | author=Koipally J, Georgopoulos K |title=Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19594–602 |year= 2000 |pmid= 10766745 |doi= 10.1074/jbc.M000254200
*cite journal | author=Yu F, Thiesen J, Strätling WH |title=Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. |journal=Nucleic Acids Res. |volume=28 |issue= 10 |pages= 2201–6 |year= 2000 |pmid= 10773092 |doi=

External links

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