SAP30

Sin3A-associated protein, 30kDa, also known as SAP30, is a human gene.cite web | title = Entrez Gene: SAP30 Sin3A-associated protein, 30kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8819| accessdate = ]

PBB_Summary
section_title =
summary_text = Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.cite web | title = Entrez Gene: SAP30 Sin3A-associated protein, 30kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8819| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ayer DE, Lawrence QA, Eisenman RN |title=Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. |journal=Cell |volume=80 |issue= 5 |pages= 767–76 |year= 1995 |pmid= 7889570 |doi=
*cite journal | author=Zhang Y, Iratni R, Erdjument-Bromage H, "et al." |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. |journal=Cell |volume=89 |issue= 3 |pages= 357–64 |year= 1997 |pmid= 9150135 |doi=
*cite journal | author=Zhang Y, Sun ZW, Iratni R, "et al." |title=SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. |journal=Mol. Cell |volume=1 |issue= 7 |pages= 1021–31 |year= 1998 |pmid= 9651585 |doi=
*cite journal | author=Laherty CD, Billin AN, Lavinsky RM, "et al." |title=SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. |journal=Mol. Cell |volume=2 |issue= 1 |pages= 33–42 |year= 1998 |pmid= 9702189 |doi=
*cite journal | author=Zhang Y, LeRoy G, Seelig HP, "et al." |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279–89 |year= 1998 |pmid= 9790534 |doi=
*cite journal | author=Tong JK, Hassig CA, Schnitzler GR, "et al." |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917–21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699
*cite journal | author=Hsieh JJ, Zhou S, Chen L, "et al." |title=CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 1 |pages= 23–8 |year= 1999 |pmid= 9874765 |doi=
*cite journal | author=Boutell JM, Thomas P, Neal JW, "et al." |title=Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1647–55 |year= 2000 |pmid= 10441327 |doi=
*cite journal | author=Zhang Y, Ng HH, Erdjument-Bromage H, "et al." |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924–35 |year= 1999 |pmid= 10444591 |doi=
*cite journal | author=Krithivas A, Young DB, Liao G, "et al." |title=Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. |journal=J. Virol. |volume=74 |issue= 20 |pages= 9637–45 |year= 2000 |pmid= 11000236 |doi=
*cite journal | author=Underhill C, Qutob MS, Yee SP, Torchia J |title=A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40463–70 |year= 2001 |pmid= 11013263 |doi= 10.1074/jbc.M007864200
*cite journal | author=Humphrey GW, Wang Y, Russanova VR, "et al." |title=Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6817–24 |year= 2001 |pmid= 11102443 |doi= 10.1074/jbc.M007372200
*cite journal | author=Skowyra D, Zeremski M, Neznanov N, "et al." |title=Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8734–9 |year= 2001 |pmid= 11118440 |doi= 10.1074/jbc.M007664200
*cite journal | author=Yochum GS, Ayer DE |title=Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. |journal=Mol. Cell. Biol. |volume=21 |issue= 13 |pages= 4110–8 |year= 2001 |pmid= 11390640 |doi= 10.1128/MCB.21.13.4110-4118.2001
*cite journal | author=Kuzmichev A, Zhang Y, Erdjument-Bromage H, "et al." |title=Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 835–48 |year= 2002 |pmid= 11784859 |doi=
*cite journal | author=Saito M, Ishikawa F |title=The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35434–9 |year= 2002 |pmid= 12124384 |doi= 10.1074/jbc.M203455200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wysocka J, Myers MP, Laherty CD, "et al." |title=Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. |journal=Genes Dev. |volume=17 |issue= 7 |pages= 896–911 |year= 2003 |pmid= 12670868 |doi= 10.1101/gad.252103
*cite journal | author=Huang NE, Lin CH, Lin YS, Yu WC |title=Modulation of YY1 activity by SAP30. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 267–75 |year= 2003 |pmid= 12788099 |doi=
*cite journal | author=Sironi E, Cerri A, Tomasini D, "et al." |title=Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. |journal=J. Cutan. Pathol. |volume=31 |issue= 4 |pages= 318–22 |year= 2004 |pmid= 15005689 |doi=

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