RBBP4

Retinoblastoma binding protein 4, also known as RBBP4, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes.cite web | title = Entrez Gene: RBBP4 retinoblastoma binding protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5928| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wolffe AP, Urnov FD, Guschin D |title=Co-repressor complexes and remodelling chromatin for repression. |journal=Biochem. Soc. Trans. |volume=28 |issue= 4 |pages= 379–86 |year= 2001 |pmid= 10961924 |doi=
*cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401–14 |year= 2003 |pmid= 12943729 |doi=
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Bauw G, Rasmussen HH, van den Bulcke M, "et al." |title=Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes. |journal=Electrophoresis |volume=11 |issue= 7 |pages= 528–36 |year= 1990 |pmid= 1699755 |doi= 10.1002/elps.1150110703
*cite journal | author=Qian YW, Lee EY |title=Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25507–13 |year= 1995 |pmid= 7503932 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Qian YW, Wang YC, Hollingsworth RE, "et al." |title=A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. |journal=Nature |volume=364 |issue= 6438 |pages= 648–52 |year= 1993 |pmid= 8350924 |doi= 10.1038/364648a0
*cite journal | author=Taunton J, Hassig CA, Schreiber SL |title=A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. |journal=Science |volume=272 |issue= 5260 |pages= 408–11 |year= 1996 |pmid= 8602529 |doi=
*cite journal | author=Verreault A, Kaufman PD, Kobayashi R, Stillman B |title=Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. |journal=Cell |volume=87 |issue= 1 |pages= 95–104 |year= 1996 |pmid= 8858152 |doi=
*cite journal | author=Zhang Y, Iratni R, Erdjument-Bromage H, "et al." |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. |journal=Cell |volume=89 |issue= 3 |pages= 357–64 |year= 1997 |pmid= 9150135 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Verreault A, Kaufman PD, Kobayashi R, Stillman B |title=Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. |journal=Curr. Biol. |volume=8 |issue= 2 |pages= 96–108 |year= 1998 |pmid= 9427644 |doi=
*cite journal | author=Hassig CA, Tong JK, Fleischer TC, "et al." |title=A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3519–24 |year= 1998 |pmid= 9520398 |doi=
*cite journal | author=Marheineke K, Krude T |title=Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 15279–86 |year= 1998 |pmid= 9614144 |doi=
*cite journal | author=Zhang Y, Sun ZW, Iratni R, "et al." |title=SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. |journal=Mol. Cell |volume=1 |issue= 7 |pages= 1021–31 |year= 1998 |pmid= 9651585 |doi=
*cite journal | author=Zhang Y, LeRoy G, Seelig HP, "et al." |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279–89 |year= 1998 |pmid= 9790534 |doi=
*cite journal | author=Tong JK, Hassig CA, Schnitzler GR, "et al." |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917–21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699
*cite journal | author=Grozinger CM, Hassig CA, Schreiber SL |title=Three proteins define a class of human histone deacetylases related to yeast Hda1p. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4868–73 |year= 1999 |pmid= 10220385 |doi=
*cite journal | author=Yarden RI, Brody LC |title=BRCA1 interacts with components of the histone deacetylase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4983–8 |year= 1999 |pmid= 10220405 |doi=
*cite journal | author=Zhang Y, Ng HH, Erdjument-Bromage H, "et al." |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924–35 |year= 1999 |pmid= 10444591 |doi=

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