TRIM33

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.cite web | title = Entrez Gene: TRIM33 tripartite motif-containing 33| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51592| accessdate = ] cite journal | author = Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H | title = TIF1gamma, a novel member of the transcriptional intermediary factor 1 family | journal = Oncogene | volume = 18 | issue = 5 | pages = 1209–17 | year = 1999 | month = February | pmid = 10022127 | doi = 10.1038/sj.onc.1202655 | url = | issn = ]

The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, transcription factors that interact with TIF1-γ have not yet been identified.

tructure

The protein is a member of the tripartite motif family.cite journal | author = Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A | title = The tripartite motif family identifies cell compartments | journal = EMBO J. | volume = 20 | issue = 9 | pages = 2140–51 | year = 2001 | month = May | pmid = 11331580 | pmc = 125245 | doi = 10.1093/emboj/20.9.2140 | url = | issn = ] This motif includes three zinc-binding domains:
* RING
* B-box type 1 zinc finger
* B-box type 2 zinc fingerand a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Venturini L, You J, Stadler M, "et al." |title=TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. |journal=Oncogene |volume=18 |issue= 5 |pages= 1209–17 |year= 1999 |pmid= 10022127 |doi= 10.1038/sj.onc.1202655
*cite journal | author=Klugbauer S, Rabes HM |title=The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. |journal=Oncogene |volume=18 |issue= 30 |pages= 4388–93 |year= 1999 |pmid= 10439047 |doi= 10.1038/sj.onc.1202824
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Peng H, Feldman I, Rauscher FJ |title=Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression. |journal=J. Mol. Biol. |volume=320 |issue= 3 |pages= 629–44 |year= 2002 |pmid= 12096914 |doi= 10.1016/S0022-2836(02)00477-1
*cite journal | author=Yoon HG, Chan DW, Reynolds AB, "et al." |title=N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 723–34 |year= 2003 |pmid= 14527417 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Dupont S, Zacchigna L, Cordenonsi M, "et al." |title=Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. |journal=Cell |volume=121 |issue= 1 |pages= 87–99 |year= 2005 |pmid= 15820681 |doi= 10.1016/j.cell.2005.01.033
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=He W, Dorn DC, Erdjument-Bromage H, "et al." |title=Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. |journal=Cell |volume=125 |issue= 5 |pages= 929–41 |year= 2006 |pmid= 16751102 |doi= 10.1016/j.cell.2006.03.045

External links

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