TRIM28

Tripartite motif-containing 28, also known as TRIM28, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.cite web | title = Entrez Gene: TRIM28 tripartite motif-containing 28| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10155| accessdate = ]

ee also

* Transcription coregulator

References

External links

*
*

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Friedman JR, Fredericks WJ, Jensen DE, "et al." |title=KAP-1, a novel corepressor for the highly conserved KRAB repression domain. |journal=Genes Dev. |volume=10 |issue= 16 |pages= 2067–78 |year= 1996 |pmid= 8769649 |doi=
*cite journal | author=Kim SS, Chen YM, O'Leary E, "et al." |title=A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15299–304 |year= 1997 |pmid= 8986806 |doi=
*cite journal | author=Moosmann P, Georgiev O, Le Douarin B, "et al." |title=Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. |journal=Nucleic Acids Res. |volume=24 |issue= 24 |pages= 4859–67 |year= 1997 |pmid= 9016654 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Chang CJ, Chen YL, Lee SC |title=Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5880–7 |year= 1998 |pmid= 9742105 |doi=
*cite journal | author=Eng FC, Barsalou A, Akutsu N, "et al." |title=Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 28371–7 |year= 1998 |pmid= 9774463 |doi=
*cite journal | author=Ryan RF, Schultz DC, Ayyanathan K, "et al." |title=KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4366–78 |year= 1999 |pmid= 10330177 |doi=
*cite journal | author=Agata Y, Matsuda E, Shimizu A |title=Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1). |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16412–22 |year= 1999 |pmid= 10347202 |doi=
*cite journal | author=Nielsen AL, Ortiz JA, You J, "et al." |title=Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. |journal=EMBO J. |volume=18 |issue= 22 |pages= 6385–95 |year= 2000 |pmid= 10562550 |doi= 10.1093/emboj/18.22.6385
*cite journal | author=Peng H, Begg GE, Harper SL, "et al." |title=Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18000–10 |year= 2000 |pmid= 10748030 |doi= 10.1074/jbc.M001499200
*cite journal | author=Lechner MS, Begg GE, Speicher DW, Rauscher FJ |title=Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6449–65 |year= 2000 |pmid= 10938122 |doi=
*cite journal | author=Underhill C, Qutob MS, Yee SP, Torchia J |title=A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40463–70 |year= 2001 |pmid= 11013263 |doi= 10.1074/jbc.M007864200
*cite journal | author=Gebelein B, Urrutia R |title=Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein. |journal=Mol. Cell. Biol. |volume=21 |issue= 3 |pages= 928–39 |year= 2001 |pmid= 11154279 |doi= 10.1128/MCB.21.3.928-939.2001
*cite journal | author=Capili AD, Schultz DC, RauscherIII FJ, Borden KL |title=Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. |journal=EMBO J. |volume=20 |issue= 1-2 |pages= 165–77 |year= 2001 |pmid= 11226167 |doi= 10.1093/emboj/20.1.165
*cite journal | author=Schultz DC, Friedman JR, Rauscher FJ |title=Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. |journal=Genes Dev. |volume=15 |issue= 4 |pages= 428–43 |year= 2001 |pmid= 11230151 |doi= 10.1101/gad.869501
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Hsu SI, Yang CM, Sim KG, "et al." |title=TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2273–85 |year= 2001 |pmid= 11331592 |doi= 10.1093/emboj/20.9.2273
*cite journal | author=Nielsen AL, Oulad-Abdelghani M, Ortiz JA, "et al." |title=Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 729–39 |year= 2001 |pmid= 11336697 |doi=
*cite journal | author=Rooney JW, Calame KL |title=TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937. |journal=Genes Dev. |volume=15 |issue= 22 |pages= 3023–38 |year= 2001 |pmid= 11711437 |doi= 10.1101/gad.937201

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes