NCOA6

Nuclear receptor coactivator 6
Identifiers
Symbols	NCOA6; AIB3; ASC2; KIAA0181; NRC; PRIP; RAP250; TRBP
External IDs	OMIM: 605299 MGI: 1929915 HomoloGene: 40920 GeneCards: NCOA6 Gene
Gene Ontology Molecular function • chromatin binding • transcription coactivator activity • protein binding • enzyme binding • estrogen receptor binding • ligand-dependent nuclear receptor transcription coactivator activity • retinoid X receptor binding • thyroid hormone receptor binding Cellular component • nucleus • nucleus • nucleoplasm • transcription factor complex • nucleolus • histone methyltransferase complex • intracellular membrane-bounded organelle Biological process • DNA replication • DNA repair • DNA recombination • transcription initiation, DNA-dependent • transcription initiation from RNA polymerase II promoter • brain development • heart development • response to hormone stimulus • myeloid cell differentiation • estrogen receptor signaling pathway • glucocorticoid receptor signaling pathway • cellular lipid metabolic process • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • labyrinthine layer blood vessel development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23054	56406
Ensembl	ENSG00000198646	ENSMUSG00000038369
UniProt	Q14686	Q3TAG3
RefSeq (mRNA)	NM_001242539.1	NM_019825
RefSeq (protein)	NP_001229468.1	NP_062799
Location (UCSC)	Chr 20: 33.3 – 33.41 Mb	Chr 2: 155.22 – 155.3 Mb
PubMed search	[1]	[2]

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.^[1][2][3]

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D₃, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.^[3]

Interactions

NCOA6 has been shown to interact with Ku70,^[4][5] RBBP5,^[6] E2F1,^[7] Retinoblastoma protein,^[8] CREB-binding protein,^[9][10] Activating transcription factor 2,^[11] HSF1,^[12] HBXIP,^[13] TGS1,^[14][15] TUBB,^[6] TUBA4A,^[6] Thyroid hormone receptor beta,^{[4][9][10][16]} Retinoic acid receptor alpha,^[4][9][10] Src,^{[6][9][10][17]} Thyroid hormone receptor alpha,^[9][17] DNA-PKcs,^[4] Androgen receptor,^[8] HIST2H3C,^[6] MLL3,^[6] Ku80,^[4][5] Liver X receptor beta,^[10] Estrogen receptor alpha,^[9][16] Estrogen receptor beta,^[10][16] EP300,^[4] ASCL2^[6] and Retinoid X receptor alpha.^{[9][10][13][16]}

See also

• Transcription coregulator

References

1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
2. ^ Estey A, Kemp M, Allison S, Lamb C (Jan 1994). "Evaluation of a patient information booklet". J Nurs Staff Dev 9 (6): 278–82. PMID 8263591. 
3. ^ ^{a b} "Entrez Gene: NCOA6 nuclear receptor coactivator 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23054. 
4. ^ ^{a b c d e f} Ko, L; Cardona G R, Chin W W (May. 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (11): 6212–7. doi:10.1073/pnas.97.11.6212. ISSN 0027-8424. PMC 18584. PMID 10823961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18584. 
5. ^ ^{a b} Ko, Lan; Chin William W (Mar. 2003). "Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase". J. Biol. Chem. (United States) 278 (13): 11471–9. doi:10.1074/jbc.M209723200. ISSN 0021-9258. PMID 12519782. 
6. ^ ^{a b c d e f g} Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (Jan. 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. (United States) 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. ISSN 0270-7306. PMC 140670. PMID 12482968. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140670. 
7. ^ Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun (Nov. 2003). "Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation". Mol. Cancer Res. (United States) 1 (13): 948–58. ISSN 1541-7786. PMID 14638867. 
8. ^ ^{a b} Goo, Young-Hwa; Na Soon-Young, Zhang Hao, Xu Jianming, Hong SunHwa, Cheong JaeHun, Lee Soo-Kyung, Lee Jae Woon (Feb. 2004). "Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation". J. Biol. Chem. (United States) 279 (8): 7131–5. doi:10.1074/jbc.M312563200. ISSN 0021-9258. PMID 14645241. 
9. ^ ^{a b c d e f g} Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. ISSN 0021-9258. PMID 10567404. 
10. ^ ^{a b c d e f g} Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb. 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. (United States) 15 (2): 241–54. doi:10.1210/me.15.2.241. ISSN 0888-8809. PMID 11158331. 
11. ^ Hong, SunHwa; Choi Hyun Mi, Park Min Jung, Kim Young Hee, Choi Yoon Ha, Kim Hyung Hoi, Choi Young Hyun, Cheong JaeHun (Apr. 2004). "Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid". J. Biol. Chem. (United States) 279 (17): 16996–7003. doi:10.1074/jbc.M311752200. ISSN 0021-9258. PMID 14734562. 
12. ^ Hong, SunHwa; Kim Sun Hee, Heo Mi Ae, Choi Yoon Ha, Park Min Jung, Yoo Mi Ae, Kim Han Do, Kang Ho Sung, Cheong JaeHun (Feb. 2004). "Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock". FEBS Lett. (Netherlands) 559 (1–3): 165–70. doi:10.1016/S0014-5793(04)00028-6. ISSN 0014-5793. PMID 14960326. 
13. ^ ^{a b} Kong, Hee Jeong; Park Min Jung, Hong SunHwa, Yu Hyun Jung, Lee Young Chul, Choi Young Hyun, Cheong JaeHun (Nov. 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology (United States) 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865. 
14. ^ Misra, Parimal; Qi Chao, Yu Songtao, Shah Sejal H, Cao Wen-Qing, Rao M Sambasiva, Thimmapaya Bayar, Zhu Yijun, Reddy Janardan K (May. 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. (United States) 277 (22): 20011–9. doi:10.1074/jbc.M201739200. ISSN 0021-9258. PMID 11912212. 
15. ^ Zhu, Y; Qi C, Cao W Q, Yeldandi A V, Rao M S, Reddy J K (Aug. 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (18): 10380–5. doi:10.1073/pnas.181347498. ISSN 0027-8424. PMC 56969. PMID 11517327. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=56969. 
16. ^ ^{a b c d} Ko, Lan; Cardona Guemalli R, Iwasaki Toshiharu, Bramlett Kelli S, Burris Thomas P, Chin William W (Jan. 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. (United States) 16 (1): 128–40. doi:10.1210/me.16.1.128. ISSN 0888-8809. PMID 11773444. 
17. ^ ^{a b} Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. doi:10.1210/me.14.6.915. ISSN 0888-8809. PMID 10847592. 

External links

• MeSH NCOA6 protein, human
• NURSA C94

Further reading

• Mahajan MA, Samuels HH (July 2000). "A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein". Mol. Cell. Biol. 20 (14): 5048–63. doi:10.1128/MCB.20.14.5048-5063.2000. PMC 85955. PMID 10866662. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85955. 
• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
• Carney JP, McKnight C, VanEpps S, Kelley MR (1995). "Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats". Gene 155 (2): 289–92. doi:10.1016/0378-1119(94)00758-K. PMID 7536696. 
• Guan XY, Xu J, Anzick SL, et al. (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer". Cancer Res. 56 (15): 3446–50. PMID 8758910. 
• Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404. 
• Caira F, Antonson P, Pelto-Huikko M, et al. (2000). "Cloning and characterization of RAP250, a novel nuclear receptor coactivator". J. Biol. Chem. 275 (8): 5308–17. doi:10.1074/jbc.275.8.5308. PMID 10681503. 
• Zhu Y, Kan L, Qi C, et al. (2000). "Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR". J. Biol. Chem. 275 (18): 13510–6. doi:10.1074/jbc.275.18.13510. PMID 10788465. 
• Ko L, Cardona GR, Chin WW (2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18584. 
• Lee SK, Na SY, Jung SY, et al. (2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi:10.1210/me.14.6.915. PMID 10847592. 
• Mahajan MA, Samuels HH (2000). "A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein". Mol. Cell. Biol. 20 (14): 5048–63. doi:10.1128/MCB.20.14.5048-5063.2000. PMC 85955. PMID 10866662. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85955. 
• Lee SK, Jung SY, Kim YS, et al. (2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331. 
• Hong S, Lee MY, Cheong J (2001). "Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell". Biochem. Biophys. Res. Commun. 282 (5): 1257–62. doi:10.1006/bbrc.2001.4727. PMID 11302752. 
• Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112. 
• Zhu Y, Qi C, Cao WQ, et al. (2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=56969. 
• Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680. 
• Ko L, Cardona GR, Iwasaki T, et al. (2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi:10.1210/me.16.1.128. PMID 11773444. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Qi C, Chang J, Zhu Y, et al. (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32): 28624–30. doi:10.1074/jbc.M201053200. PMID 12039952. 
• Espejo F, Green M, Preece NE, Assa-Munt N (2003). "NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation". J. Biomol. NMR 23 (2): 151–2. doi:10.1023/A:1016398403157. PMID 12153040. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.