Histone acetyltransferase
- Histone acetyltransferase
protein
Name=Histone Acetyltransferase 1
caption=
width=
HGNCid=4821
Symbol=HAT1
AltSymbols=
EntrezGene=8520
OMIM=603053
RefSeq=NM_003642
UniProt=O14929
PDB=
ECnumber=2.3.1.48
Chromosome=2
Arm=q
Band=31.2-33.1
LocusSupplementaryData=
Histone acetyltransferases (HAT) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to lysine to form ε-N-acetyl lysine.
Histone acetylation is generally linked to transcriptional activation. These are generally associated with euchromatin. Initially, it was thought that acetylation of lysine neutralizes the positive charge normally present, thus reducing affinity between histone and (negatively charged) DNA which renders DNA more accessible to transcription factors. More recently, it has emerged that lysine acetylation and other posttranslational modifications of histones generate binding sites for specific protein-protein interaction domains, such as the acetyl-lysine binding bromodomain.Fact|date=July 2008
Interaction with HDACs
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are recruited to their target promoters through a physical interaction with a sequence-specific transcription factor (TF). They usually function within a multimolecular complex ('enzymatic complex'), in which the other subunits are necessary for them to modify nucleosomes around the binding site. These enzymes can also modify factors other than histones (protein X)
ee also
*Histone-Modifying Enzymes
*Histone deacetylase
*Histone methyltransferase
*RNA polymerase control by chromatin structure
*Acetyltransferase
External links
*
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2010.
Look at other dictionaries:
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Histone deacetylase — Histone deacetylases (HDAC) (EC number 3.5.1) are a class of enzymes that remove acetyl groups from an ε N acetyl lysine amino acid on a histone. Its action is opposite to that of histone acetyltransferase.ubtypesHDAC proteins are found in three… … Wikipedia
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Acétyltransférase — Structure d un groupe acétyle Une acétyltransférase (ou transacétylase) est une enzyme de type transférase qui transfère un groupe acétyle. Ces enzymes font donc partie des acyltransférases (EC 2.3) et forment, avec d autres, la sous classe EC… … Wikipédia en Français
Choline acetyltransferase — Identifiers EC number 2.3.1.6 CAS number 9012 78 6 … Wikipedia
