GPS2 (gene)

G protein pathway suppressor 2, also known as GPS2, is a human gene.cite web | title = Entrez Gene: GPS2 G protein pathway suppressor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2874| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.cite web | title = Entrez Gene: GPS2 G protein pathway suppressor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2874| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Spain BH, Bowdish KS, Pacal AR, "et al." |title=Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6698–706 |year= 1997 |pmid= 8943324 |doi=
*cite journal | author=Jin DY, Teramoto H, Giam CZ, "et al." |title=A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25816–23 |year= 1997 |pmid= 9325311 |doi=
*cite journal | author=Peng YC, Breiding DE, Sverdrup F, "et al." |title=AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. |journal=J. Virol. |volume=74 |issue= 13 |pages= 5872–9 |year= 2000 |pmid= 10846067 |doi=
*cite journal | author=Degenhardt YY, Silverstein SJ |title=Gps2, a protein partner for human papillomavirus E6 proteins. |journal=J. Virol. |volume=75 |issue= 1 |pages= 151–60 |year= 2001 |pmid= 11119584 |doi= 10.1128/JVI.75.1.151-160.2001
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Nagase T, Nakayama M, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=
*cite journal | author=Peng YC, Kuo F, Breiding DE, "et al." |title=AMF1 (GPS2) modulates p53 transactivation. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 5913–24 |year= 2001 |pmid= 11486030 |doi=
*cite journal | author=Zhang J, Kalkum M, Chait BT, Roeder RG |title=The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 611–23 |year= 2002 |pmid= 11931768 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yoon HG, Chan DW, Huang ZQ, "et al." |title=Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1336–46 |year= 2003 |pmid= 12628926 |doi= 10.1093/emboj/cdg120
*cite journal | author=Yoon HG, Chan DW, Reynolds AB, "et al." |title=N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 723–34 |year= 2003 |pmid= 14527417 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Diederichs S, Bäumer N, Ji P, "et al." |title=Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33727–41 |year= 2004 |pmid= 15159402 |doi= 10.1074/jbc.M401708200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lee TH, Yi W, Griswold MD, "et al." |title=Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment. |journal=DNA Repair (Amst.) |volume=5 |issue= 1 |pages= 32–42 |year= 2006 |pmid= 16122992 |doi= 10.1016/j.dnarep.2005.07.004
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Sanyal S, Båvner A, Haroniti A, "et al." |title=Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 40 |pages= 15665–70 |year= 2007 |pmid= 17895379 |doi= 10.1073/pnas.0706736104

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