MAP3K7IP2

Mitogen-activated protein kinase kinase kinase 7 interacting protein 2, also known as MAP3K7IP2, is a human gene.cite journal | author = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K | title = TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway | journal = Mol. Cell | volume = 5 | issue = 4 | pages = 649–58 | year = 2000 | month = April | pmid = 10882101 | doi = 10.1016/S1097-2765(00)80244-0 | url = | issn = ] cite web | title = Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23118| accessdate = ]

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

References

Further reading

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*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Shibuya H, Yamaguchi K, Shirakabe K, "et al." |title=TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. |journal=Science |volume=272 |issue= 5265 |pages= 1179–82 |year= 1996 |pmid= 8638164 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=Takaesu G, Kishida S, Hiyama A, "et al." |title=TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. |journal=Mol. Cell |volume=5 |issue= 4 |pages= 649–58 |year= 2000 |pmid= 10882101 |doi=
*cite journal | author=Takaesu G, Ninomiya-Tsuji J, Kishida S, "et al." |title=Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. |journal=Mol. Cell. Biol. |volume=21 |issue= 7 |pages= 2475–84 |year= 2001 |pmid= 11259596 |doi= 10.1128/MCB.21.7.2475-2484.2001
*cite journal | author=Qian Y, Commane M, Ninomiya-Tsuji J, "et al." |title=IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41661–7 |year= 2001 |pmid= 11518704 |doi= 10.1074/jbc.M102262200
*cite journal | author=Mizukami J, Takaesu G, Akatsuka H, "et al." |title=Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. |journal=Mol. Cell. Biol. |volume=22 |issue= 4 |pages= 992–1000 |year= 2002 |pmid= 11809792 |doi=
*cite journal | author=Sanna MG, da Silva Correia J, Luo Y, "et al." |title=ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30454–62 |year= 2002 |pmid= 12048196 |doi= 10.1074/jbc.M203312200
*cite journal | author=Baek SH, Ohgi KA, Rose DW, "et al." |title=Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. |journal=Cell |volume=110 |issue= 1 |pages= 55–67 |year= 2002 |pmid= 12150997 |doi=
*cite journal | author=Jiang Z, Ninomiya-Tsuji J, Qian Y, "et al." |title=Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. |journal=Mol. Cell. Biol. |volume=22 |issue= 20 |pages= 7158–67 |year= 2002 |pmid= 12242293 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jiang Z, Zamanian-Daryoush M, Nie H, "et al." |title=Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR . |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16713–9 |year= 2003 |pmid= 12609980 |doi= 10.1074/jbc.M300562200
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ishitani T, Takaesu G, Ninomiya-Tsuji J, "et al." |title=Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. |journal=EMBO J. |volume=22 |issue= 23 |pages= 6277–88 |year= 2004 |pmid= 14633987 |doi= 10.1093/emboj/cdg605
*cite journal | author=Cheung PC, Nebreda AR, Cohen P |title=TAB3, a new binding partner of the protein kinase TAK1. |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 27–34 |year= 2004 |pmid= 14670075 |doi= 10.1042/BJ20031794
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Owerbach D, Piña L, Gabbay KH |title=A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. |journal=Diabetes |volume=53 |issue= 7 |pages= 1890–3 |year= 2004 |pmid= 15220215 |doi=
*cite journal | author=Kanayama A, Seth RB, Sun L, "et al." |title=TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. |journal=Mol. Cell |volume=15 |issue= 4 |pages= 535–48 |year= 2004 |pmid= 15327770 |doi= 10.1016/j.molcel.2004.08.008

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