MAP3K7IP1

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, also known as MAP3K7IP1, is a human gene.cite web | title = Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10454| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10454| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shibuya H, Yamaguchi K, Shirakabe K, "et al." |title=TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. |journal=Science |volume=272 |issue= 5265 |pages= 1179–82 |year= 1996 |pmid= 8638164 |doi=
*cite journal | author=Kurozumi K, Nishita M, Yamaguchi K, "et al." |title=BRAM1, a BMP receptor-associated molecule involved in BMP signalling. |journal=Genes Cells |volume=3 |issue= 4 |pages= 257–64 |year= 1998 |pmid= 9663660 |doi=
*cite journal | author=Yamaguchi K, Nagai S, Ninomiya-Tsuji J, "et al." |title=XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. |journal=EMBO J. |volume=18 |issue= 1 |pages= 179–87 |year= 1999 |pmid= 9878061 |doi= 10.1093/emboj/18.1.179
*cite journal | author=Ninomiya-Tsuji J, Kishimoto K, Hiyama A, "et al." |title=The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. |journal=Nature |volume=398 |issue= 6724 |pages= 252–6 |year= 1999 |pmid= 10094049 |doi= 10.1038/18465
*cite journal | author=Sakurai H, Miyoshi H, Toriumi W, Sugita T |title=Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10641–8 |year= 1999 |pmid= 10187861 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Kishimoto K, Matsumoto K, Ninomiya-Tsuji J |title=TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7359–64 |year= 2000 |pmid= 10702308 |doi=
*cite journal | author=Sakurai H, Miyoshi H, Mizukami J, Sugita T |title=Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. |journal=FEBS Lett. |volume=474 |issue= 2-3 |pages= 141–5 |year= 2000 |pmid= 10838074 |doi=
*cite journal | author=Ono K, Ohtomo T, Sato S, "et al." |title=An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24396–400 |year= 2001 |pmid= 11323434 |doi= 10.1074/jbc.M102631200
*cite journal | author=Qian Y, Commane M, Ninomiya-Tsuji J, "et al." |title=IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41661–7 |year= 2001 |pmid= 11518704 |doi= 10.1074/jbc.M102262200
*cite journal | author=Yanagisawa M, Nakashima K, Takeda K, "et al." |title=Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. |journal=Genes Cells |volume=6 |issue= 12 |pages= 1091–9 |year= 2002 |pmid= 11737269 |doi=
*cite journal | author=Ge B, Gram H, Di Padova F, "et al." |title=MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. |journal=Science |volume=295 |issue= 5558 |pages= 1291–4 |year= 2002 |pmid= 11847341 |doi= 10.1126/science.1067289
*cite journal | author=Sakurai H, Nishi A, Sato N, "et al." |title=TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 5 |pages= 1277–81 |year= 2002 |pmid= 12372426 |doi=
*cite journal | author=Ge B, Xiong X, Jing Q, "et al." |title=TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2286–93 |year= 2003 |pmid= 12429732 |doi= 10.1074/jbc.M210918200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ishitani T, Kishida S, Hyodo-Miura J, "et al." |title=The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 131–9 |year= 2003 |pmid= 12482967 |doi=
*cite journal | author=Suzawa M, Takada I, Yanagisawa J, "et al." |title=Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. |journal=Nat. Cell Biol. |volume=5 |issue= 3 |pages= 224–30 |year= 2003 |pmid= 12598905 |doi= 10.1038/ncb942
*cite journal | author=Tanno M, Bassi R, Gorog DA, "et al." |title=Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. |journal=Circ. Res. |volume=93 |issue= 3 |pages= 254–61 |year= 2003 |pmid= 12829618 |doi= 10.1161/01.RES.0000083490.43943.85
*cite journal | author=Channavajhala PL, Wu L, Cuozzo JW, "et al." |title=Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47089–97 |year= 2004 |pmid= 12975377 |doi= 10.1074/jbc.M306002200
*cite journal | author=Cheung PC, Nebreda AR, Cohen P |title=TAB3, a new binding partner of the protein kinase TAK1. |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 27–34 |year= 2004 |pmid= 14670075 |doi= 10.1042/BJ20031794

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