MAP3K7IP3

Mitogen-activated protein kinase kinase kinase 7 interacting protein 3, also known as MAP3K7IP3, is a human gene.cite web | title = Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=257397| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.cite web | title = Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=257397| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ishitani T, Takaesu G, Ninomiya-Tsuji J, "et al." |title=Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. |journal=EMBO J. |volume=22 |issue= 23 |pages= 6277–88 |year= 2004 |pmid= 14633987 |doi= 10.1093/emboj/cdg605
*cite journal | author=Cheung PC, Nebreda AR, Cohen P |title=TAB3, a new binding partner of the protein kinase TAK1. |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 27–34 |year= 2004 |pmid= 14670075 |doi= 10.1042/BJ20031794
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Jin G, Klika A, Callahan M, "et al." |title=Identification of a human NF-kappaB-activating protein, TAB3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 7 |pages= 2028–33 |year= 2004 |pmid= 14766965 |doi= 10.1073/pnas.0307314101
*cite journal | author=Kanayama A, Seth RB, Sun L, "et al." |title=TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. |journal=Mol. Cell |volume=15 |issue= 4 |pages= 535–48 |year= 2004 |pmid= 15327770 |doi= 10.1016/j.molcel.2004.08.008
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Besse A, Lamothe B, Campos AD, "et al." |title=TAK1-dependent signaling requires functional interaction with TAB2/TAB3. |journal=J. Biol. Chem. |volume=282 |issue= 6 |pages= 3918–28 |year= 2007 |pmid= 17158449 |doi= 10.1074/jbc.M608867200

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