Promyelocytic leukemia protein

Promyelocytic leukemia, also known as PML, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [cite web | title = Entrez Gene: PML promyelocytic leukemia| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5371| accessdate = ]

ee also

* RING finger domain

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhong S, Salomoni P, Pandolfi PP |title=The transcriptional role of PML and the nuclear body. |journal=Nat. Cell Biol. |volume=2 |issue= 5 |pages= E85–90 |year= 2000 |pmid= 10806494 |doi= 10.1038/35010583
*cite journal | author=Jensen K, Shiels C, Freemont PS |title=PML protein isoforms and the RBCC/TRIM motif. |journal=Oncogene |volume=20 |issue= 49 |pages= 7223–33 |year= 2001 |pmid= 11704850 |doi= 10.1038/sj.onc.1204765
*cite journal | author=Pearson M, Pelicci PG |title=PML interaction with p53 and its role in apoptosis and replicative senescence. |journal=Oncogene |volume=20 |issue= 49 |pages= 7250–6 |year= 2001 |pmid= 11704853 |doi= 10.1038/sj.onc.1204856
*cite journal | author=Salomoni P, Pandolfi PP |title=The role of PML in tumor suppression. |journal=Cell |volume=108 |issue= 2 |pages= 165–70 |year= 2002 |pmid= 11832207 |doi=
*cite journal | author=Combes R, Balls M, Bansil L, "et al." |title=An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). |journal=Alternatives to laboratory animals : ATLA |volume=30 |issue= 4 |pages= 365–406 |year= 2002 |pmid= 12234245 |doi=
*cite journal | author=Bernardi R, Pandolfi PP |title=Role of PML and the PML-nuclear body in the control of programmed cell death. |journal=Oncogene |volume=22 |issue= 56 |pages= 9048–57 |year= 2004 |pmid= 14663483 |doi= 10.1038/sj.onc.1207106

External links

*

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