APBA2

Amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like), also known as APBA2, is a human gene.cite web | title = Entrez Gene: APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=321| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.cite web | title = Entrez Gene: APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=321| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=van der Geer P, Pawson T |title=The PTB domain: a new protein module implicated in signal transduction. |journal=Trends Biochem. Sci. |volume=20 |issue= 7 |pages= 277–80 |year= 1995 |pmid= 7545337 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=McLoughlin DM, Miller CC |title=The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. |journal=FEBS Lett. |volume=397 |issue= 2-3 |pages= 197–200 |year= 1997 |pmid= 8955346 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Okamoto M, Südhof TC |title=Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31459–64 |year= 1998 |pmid= 9395480 |doi=
*cite journal | author=Blanco G, Irving NG, Brown SD, "et al." |title=Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. |journal=Mamm. Genome |volume=9 |issue= 6 |pages= 473–5 |year= 1998 |pmid= 9585438 |doi=
*cite journal | author=Borg JP, Yang Y, De Taddéo-Borg M, "et al." |title=The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 14761–6 |year= 1998 |pmid= 9614075 |doi=
*cite journal | author=Borg JP, Straight SW, Kaech SM, "et al." |title=Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31633–6 |year= 1998 |pmid= 9822620 |doi=
*cite journal | author=Okamoto M, Südhof TC |title=Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2. |journal=Eur. J. Cell Biol. |volume=77 |issue= 3 |pages= 161–5 |year= 1999 |pmid= 9860131 |doi=
*cite journal | author=Tomita S, Ozaki T, Taru H, "et al." |title=Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2243–54 |year= 1999 |pmid= 9890987 |doi=
*cite journal | author=McLoughlin DM, Irving NG, Brownlees J, "et al." |title=Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease. |journal=Eur. J. Neurosci. |volume=11 |issue= 6 |pages= 1988–94 |year= 1999 |pmid= 10336668 |doi=
*cite journal | author=Tomita S, Fujita T, Kirino Y, Suzuki T |title=PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 13056–60 |year= 2000 |pmid= 10777610 |doi=
*cite journal | author=Gotthardt M, Trommsdorff M, Nevitt MF, "et al." |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25616–24 |year= 2000 |pmid= 10827173 |doi= 10.1074/jbc.M000955200
*cite journal | author=Lee DS, Tomita S, Kirino Y, Suzuki T |title=Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23134–8 |year= 2000 |pmid= 10833507 |doi= 10.1074/jbc.C000302200
*cite journal | author=Biederer T, Südhof TC |title=Mints as adaptors. Direct binding to neurexins and recruitment of munc18. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39803–6 |year= 2001 |pmid= 11036064 |doi= 10.1074/jbc.C000656200
*cite journal | author=Lau KF, McLoughlin DM, Standen C, Miller CC |title=X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. |journal=Mol. Cell. Neurosci. |volume=16 |issue= 5 |pages= 557–65 |year= 2001 |pmid= 11083918 |doi= 10.1006/mcne.2000.0898
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sutcliffe JS, Han MK, Amin T, "et al." |title=Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures. |journal=BMC Genomics |volume=4 |issue= 1 |pages= 15 |year= 2003 |pmid= 12720574 |doi= 10.1186/1471-2164-4-15
*cite journal | author=Sumioka A, Imoto S, Martins RN, "et al." |title=XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. |journal=Biochem. J. |volume=374 |issue= Pt 1 |pages= 261–8 |year= 2003 |pmid= 12780348 |doi= 10.1042/BJ20030489

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