APBA1

Amyloid beta (A4) precursor protein-binding, family A, member 1 (X11), also known as APBA1, is a human gene.cite web | title = Entrez Gene: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=320| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.cite web | title = Entrez Gene: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=320| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=van der Geer P, Pawson T |title=The PTB domain: a new protein module implicated in signal transduction. |journal=Trends Biochem. Sci. |volume=20 |issue= 7 |pages= 277–80 |year= 1995 |pmid= 7545337 |doi=
*cite journal | author=Chen WJ, Goldstein JL, Brown MS |title=NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. |journal=J. Biol. Chem. |volume=265 |issue= 6 |pages= 3116–23 |year= 1990 |pmid= 1968060 |doi=
*cite journal | author=Duclos F, Boschert U, Sirugo G, "et al." |title=Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 1 |pages= 109–13 |year= 1993 |pmid= 7678331 |doi=
*cite journal | author=Duclos F, Koenig M |title=Comparison of primary structure of a neuron-specific protein, X11, between human and mouse. |journal=Mamm. Genome |volume=6 |issue= 1 |pages= 57–8 |year= 1995 |pmid= 7719031 |doi=
*cite journal | author=Borg JP, Ooi J, Levy E, Margolis B |title=The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6229–41 |year= 1996 |pmid= 8887653 |doi=
*cite journal | author=Zhang Z, Lee CH, Mandiyan V, "et al." |title=Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. |journal=EMBO J. |volume=16 |issue= 20 |pages= 6141–50 |year= 1997 |pmid= 9321393 |doi= 10.1093/emboj/16.20.6141
*cite journal | author=Okamoto M, Südhof TC |title=Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31459–64 |year= 1998 |pmid= 9395480 |doi=
*cite journal | author=Blanco G, Irving NG, Brown SD, "et al." |title=Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. |journal=Mamm. Genome |volume=9 |issue= 6 |pages= 473–5 |year= 1998 |pmid= 9585438 |doi=
*cite journal | author=Borg JP, Yang Y, De Taddéo-Borg M, "et al." |title=The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 14761–6 |year= 1998 |pmid= 9614075 |doi=
*cite journal | author=Butz S, Okamoto M, Südhof TC |title=A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. |journal=Cell |volume=94 |issue= 6 |pages= 773–82 |year= 1998 |pmid= 9753324 |doi=
*cite journal | author=Borg JP, Straight SW, Kaech SM, "et al." |title=Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31633–6 |year= 1998 |pmid= 9822620 |doi=
*cite journal | author=Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, "et al." |title=Molecular analysis of the X11-mLin-2/CASK complex in brain. |journal=J. Neurosci. |volume=19 |issue= 4 |pages= 1307–16 |year= 1999 |pmid= 9952408 |doi=
*cite journal | author=Maximov A, Südhof TC, Bezprozvanny I |title=Association of neuronal calcium channels with modular adaptor proteins. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24453–6 |year= 1999 |pmid= 10455105 |doi=
*cite journal | author=Mueller HT, Borg JP, Margolis B, Turner RS |title=Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39302–6 |year= 2001 |pmid= 11010978 |doi= 10.1074/jbc.M008453200
*cite journal | author=Biederer T, Südhof TC |title=Mints as adaptors. Direct binding to neurexins and recruitment of munc18. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39803–6 |year= 2001 |pmid= 11036064 |doi= 10.1074/jbc.C000656200
*cite journal | author=Lau KF, McLoughlin DM, Standen C, Miller CC |title=X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. |journal=Mol. Cell. Neurosci. |volume=16 |issue= 5 |pages= 557–65 |year= 2001 |pmid= 11083918 |doi= 10.1006/mcne.2000.0898
*cite journal | author=McLoughlin DM, Standen CL, Lau KF, "et al." |title=The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 9303–7 |year= 2001 |pmid= 11115513 |doi= 10.1074/jbc.M010023200
*cite journal | author=Bécamel C, Alonso G, Galéotti N, "et al." |title=Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. |journal=EMBO J. |volume=21 |issue= 10 |pages= 2332–42 |year= 2002 |pmid= 12006486 |doi= 10.1093/emboj/21.10.2332
*cite journal | author=Ho CS, Marinescu V, Steinhilb ML, "et al." |title=Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27021–8 |year= 2002 |pmid= 12016213 |doi= 10.1074/jbc.M201823200

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