Bcl-2-interacting killer

BCL2-interacting killer (apoptosis-inducing), also known as BIK, is a human gene.cite web | title = Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=638| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.cite web | title = Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=638| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Boyd JM, Gallo GJ, Elangovan B, "et al." |title=Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. |journal=Oncogene |volume=11 |issue= 9 |pages= 1921–8 |year= 1995 |pmid= 7478623 |doi=
*cite journal | author=Chittenden T, Flemington C, Houghton AB, "et al." |title=A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5589–96 |year= 1996 |pmid= 8521816 |doi=
*cite journal | author=Han J, Sabbatini P, White E |title=Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5857–64 |year= 1996 |pmid= 8816500 |doi=
*cite journal | author=Inohara N, Ding L, Chen S, Núñez G |title=harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). |journal=EMBO J. |volume=16 |issue= 7 |pages= 1686–94 |year= 1997 |pmid= 9130713 |doi= 10.1093/emboj/16.7.1686
*cite journal | author=Huang DC, Adams JM, Cory S |title=The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. |journal=EMBO J. |volume=17 |issue= 4 |pages= 1029–39 |year= 1998 |pmid= 9463381 |doi= 10.1093/emboj/17.4.1029
*cite journal | author=Hegde R, Srinivasula SM, Ahmad M, "et al." |title=Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7783–6 |year= 1998 |pmid= 9525867 |doi=
*cite journal | author=Ohi N, Tokunaga A, Tsunoda H, "et al." |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314–25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493
*cite journal | author=Holmgreen SP, Huang DC, Adams JM, Cory S |title=Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. |journal=Cell Death Differ. |volume=6 |issue= 6 |pages= 525–32 |year= 1999 |pmid= 10381646 |doi= 10.1038/sj.cdd.4400519
*cite journal | author=Castells A, Ino Y, Louis DN, "et al." |title=Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer. |journal=Gastroenterology |volume=117 |issue= 4 |pages= 831–7 |year= 1999 |pmid= 10500065 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Verma S, Budarf ML, Emanuel BS, Chinnadurai G |title=Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences. |journal=Gene |volume=254 |issue= 1-2 |pages= 157–62 |year= 2000 |pmid= 10974546 |doi=
*cite journal | author=Jiang A, Clark EA |title=Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6025–33 |year= 2001 |pmid= 11342619 |doi=
*cite journal | author=Federici M, Hribal M, Perego L, "et al." |title=High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. |journal=Diabetes |volume=50 |issue= 6 |pages= 1290–301 |year= 2001 |pmid= 11375329 |doi=
*cite journal | author=Zou Y, Peng H, Zhou B, "et al." |title=Systemic tumor suppression by the proapoptotic gene bik. |journal=Cancer Res. |volume=62 |issue= 1 |pages= 8–12 |year= 2002 |pmid= 11782349 |doi=
*cite journal | author=Germain M, Mathai JP, Shore GC |title=BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 18053–60 |year= 2002 |pmid= 11884414 |doi= 10.1074/jbc.M201235200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gillissen B, Essmann F, Graupner V, "et al." |title=Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. |journal=EMBO J. |volume=22 |issue= 14 |pages= 3580–90 |year= 2003 |pmid= 12853473 |doi= 10.1093/emboj/cdg343
*cite journal | author=Arena V, Martini M, Luongo M, "et al." |title=Mutations of the BIK gene in human peripheral B-cell lymphomas. |journal=Genes Chromosomes Cancer |volume=38 |issue= 1 |pages= 91–6 |year= 2003 |pmid= 12874789 |doi= 10.1002/gcc.10245
*cite journal | author=Hur J, Chesnes J, Coser KR, "et al." |title=The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2351–6 |year= 2004 |pmid= 14983013 |doi=
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84

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