APBB2

Amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like), also known as APBB2, is a human gene.cite web | title = Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=323| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.cite web | title = Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=323| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Guénette SY, Chen J, Jondro PD, Tanzi RE |title=Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 10832–7 |year= 1996 |pmid= 8855266 |doi=
*cite journal | author=McLoughlin DM, Miller CC |title=The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. |journal=FEBS Lett. |volume=397 |issue= 2-3 |pages= 197–200 |year= 1997 |pmid= 8955346 |doi=
*cite journal | author=Blanco G, Irving NG, Brown SD, "et al." |title=Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. |journal=Mamm. Genome |volume=9 |issue= 6 |pages= 473–5 |year= 1998 |pmid= 9585438 |doi=
*cite journal | author=Bruni P, Minopoli G, Brancaccio T, "et al." |title=Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35481–8 |year= 2002 |pmid= 12089154 |doi= 10.1074/jbc.M205227200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chang Y, Tesco G, Jeong WJ, "et al." |title=Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51100–7 |year= 2004 |pmid= 14527950 |doi= 10.1074/jbc.M309561200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Li Y, Hollingworth P, Moore P, "et al." |title=Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. |journal=Hum. Mutat. |volume=25 |issue= 3 |pages= 270–7 |year= 2006 |pmid= 15714520 |doi= 10.1002/humu.20138
*cite journal | author=Lange A, Thon L, Mathieu S, Adam D |title=The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor. |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 2 |pages= 575–83 |year= 2005 |pmid= 16083851 |doi= 10.1016/j.bbrc.2005.07.125
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Hong Q, Hsu LJ, Schultz L, "et al." |title=Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. |journal=BMC Mol. Biol. |volume=8 |issue= |pages= 50 |year= 2007 |pmid= 17567906 |doi= 10.1186/1471-2199-8-50

PBB_Controls
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