GDF15

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.cite journal |author=Zimmers T, Jin X, Hsiao E, McGrath S, Esquela A, Koniaris L |title=Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury |journal=Shock |volume=23 |issue=6 |pages=543–8 |year=2005 |pmid=15897808] GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.cite journal |author=Hsiao E, Koniaris L, Zimmers-Koniaris T, Sebald S, Huynh T, Lee S |title=Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury |journal=Mol Cell Biol |volume=20 |issue=10 |pages=3742–51 |year=2000 |pmid=10779363 |doi=10.1128/MCB.20.10.3742-3751.2000] GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. [cite journal |author=Ago T, Sadoshima J |title=GDF15, a cardioprotective TGF-beta superfamily protein |journal=Circ Res |volume=98 |issue=3 |pages=294–7 |year=2006 |pmid=16484622 |doi=10.1161/01.RES.0000207919.83894.9d]

References

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