Chordin

CHRD domain
Identifiers
Symbol	CHRD
Pfam	PF07452
InterPro	IPR010895
SMART	SM00754
PROSITE	PS50933
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Chordin
Identifiers
Symbol	CHRD
Entrez	8646
HUGO	1949
OMIM	603475
RefSeq	NM_003741
UniProt	Q9H2X0
Other data
Locus	Chr. 3 q27

Chordin is a polypeptide that dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins.^[1] It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.^[2]

In humans, the chordin peptide is encoded by the CHRD gene.^[3]

References

1. ^ Pappano WN, Scott IC, Clark TG, Eddy RL, Shows TB, Greenspan DS (September 1998). "Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes". Genomics 52 (2): 236–9. doi:10.1006/geno.1998.5474. PMID 9782094. 
2. ^ Millet C, Lemaire P, Orsetti B, Guglielmi P, François V (August 2001). "The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities". Mech. Dev. 106 (1-2): 85–96. doi:10.1016/S0925-4773(01)00423-3. PMID 11472837. 
3. ^ Smith M, Herrell S, Lusher M, Lako L, Simpson C, Wiestner A, Skoda R, Ireland M, Strachan T (1999). "Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes". Hum. Genet. 105 (1-2): 104–11. doi:10.1007/s004390051070. PMID 10480362.