CRIM1

Cysteine rich transmembrane BMP regulator 1 (chordin-like), also known as CRIM1, is a human gene.cite web | title = Entrez Gene: CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51232| accessdate = ]

PBB_Summary
section_title =
summary_text = Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000). [supplied by OMIM] cite web | title = Entrez Gene: CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51232| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Wilkinson L, Kolle G, Wen D, "et al." |title=CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34181-8 |year= 2003 |pmid= 12805376 |doi= 10.1074/jbc.M301247200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Glienke J, Sturz A, Menrad A, Thierauch KH |title=CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. |journal=Mech. Dev. |volume=119 |issue= 2 |pages= 165-75 |year= 2003 |pmid= 12464430 |doi=
*cite journal | author=Georgas K, Bowles J, Yamada T, "et al." |title=Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern. |journal=Dev. Dyn. |volume=219 |issue= 4 |pages= 582-7 |year= 2001 |pmid= 11084657 |doi= 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1072>3.0.CO;2-I
*cite journal | author=Kolle G, Georgas K, Holmes GP, "et al." |title=CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. |journal=Mech. Dev. |volume=90 |issue= 2 |pages= 181-93 |year= 2000 |pmid= 10642437 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes