Lefty (protein)

Lefty (protein)

protein
Name = left-right determination factor 1
caption =


width =
HGNCid = 6552
Symbol = LEFTY1
AltSymbols = LEFTB
EntrezGene = 10637
OMIM = 603037
RefSeq = NM_020997
UniProt = O75610
PDB =
ECnumber =
Chromosome = 1
Arm = q
Band = 42.1
LocusSupplementaryData = protein
Name = left-right determination factor 2
caption =


width =
HGNCid = 3122
Symbol = LEFTY2
AltSymbols = TGFB4, EBAF
EntrezGene = 7044
OMIM = 601877
RefSeq = NM_003240
UniProt = O00292
PDB =
ECnumber =
Chromosome = 1
Arm = q
Band = 42.1
LocusSupplementaryData =

Lefty is a class of proteins that belongs to the TGF beta superfamily of proteins. It regulates TGFβ.

It is involved in embryogenesis and left-right patterning. There are many differences between the left and right sides, including heart and lung positioning. Mutations in these genes cause incorrect positioning of these organs (e.g. situs invertis). Lefty1 in the ventral midline prevents the Cerebrus (paracrine factor or "Caronte")signal from passing to the right side of the embryo.

There are two human subtypes: Lefty 1 and Lefty 2. Lefty2 may play a role in endometrial bleeding.

External links

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