Growth differentiation factor-9

Growth differentiation factor-9

Growth differentiation factor 9, also known as GDF9, is a human gene.cite web | title = Entrez Gene: GDF9 growth differentiation factor 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2661| accessdate = ]

PBB_Summary
section_title =
summary_text = Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta (TGFβ) superfamily.cite web | title = Entrez Gene: GDF9 growth differentiation factor 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2661| accessdate = ]

GDF9 plays an important role in the development of primary follicles in the ovary. [cite journal |author=Juengel J, Bodensteiner K, Heath D, Hudson N, Moeller C, Smith P, Galloway S, Davis G, Sawyer H, McNatty K |title=Physiology of GDF9 and BMP15 signalling molecules |journal=Anim Reprod Sci |volume=82-83 |issue= |pages=447–60 |year= |pmid=15271472 |doi=10.1016/j.anireprosci.2004.04.021] It has a critical role in granulosa cell and theca cell growth, as well as in differentiation and maturation of the oocyte. [cite journal |author=Hreinsson J, Scott J, Rasmussen C, Swahn M, Hsueh A, Hovatta O |title=Growth differentiation factor-9 promotes the growth, development, and survival of human ovarian follicles in organ culture |journal=J Clin Endocrinol Metab |volume=87 |issue=1 |pages=316–21 |year=2002 |pmid=11788667 |doi=10.1210/jc.87.1.316 [http://jcem.endojournals.org/cgi/content/abstract/87/1/316 link] ] [cite journal |author=Su Y, Wu X, O'Brien M, Pendola F, Denegre J, Matzuk M, Eppig J |title=Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop |journal=Dev Biol |volume=276 |issue=1 |pages=64–73 |year=2004 |pmid=15531364 |doi=10.1016/j.ydbio.2004.08.020]

GDF9 has been connected to differences in ovulation rate [cite journal |author=McNatty K, Hudson N, Whiting L, Reader K, Lun S, Western A, Heath D, Smith P, Moore L, Juengel J |title=The Effects of Immunizing Sheep with Different BMP15 or GDF9 Peptide Sequences on Ovarian Follicular Activity and Ovulation Rate |journal=Biol Reprod |volume= |issue= |pages= |year= |pmid=17093201] [cite journal |author=Juengel J, Hudson N, Whiting L, McNatty K |title=Effects of immunization against bone morphogenetic protein 15 and growth differentiation factor 9 on ovulation rate, fertilization, and pregnancy in ewes |journal=Biol Reprod |volume=70 |issue=3 |pages=557–61 |year=2004 |pmid=14585806 |doi=10.1095/biolreprod.103.023333] and in premature cessation of ovary function, [cite journal |author=Kovanci E, Rohozinski J, Simpson J, Heard M, Bishop C, Carson S |title=Growth differentiating factor-9 mutations may be associated with premature ovarian failure |journal=Fertil Steril |volume=87 |issue=1 |pages=143–6 |year=2007 |pmid=17156781 |doi=10.1016/j.fertnstert.2006.05.079] therefore has a significant role in fertility.

The cell surface receptor through which GDF9 generates a signal is the bone morphogenetic protein type II receptor (BMPR2). [cite journal |author=Mazerbourg S, Hsueh A |title=Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands |journal=Hum Reprod Update |volume=12 |issue=4 |pages=373–83 |year= |pmid=16603567 |doi=10.1093/humupd/dml014] [cite journal |author=Vitt U, Mazerbourg S, Klein C, Hsueh A |title=Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9 |journal=Biol Reprod |volume=67 |issue=2 |pages=473–80 |year=2002 |pmid=12135884 |doi=10.1095/biolreprod67.2.473]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McGrath SA, Esquela AF, Lee SJ |title=Oocyte-specific expression of growth/differentiation factor-9. |journal=Mol. Endocrinol. |volume=9 |issue= 1 |pages= 131–6 |year= 1995 |pmid= 7760846 |doi=
*cite journal | author=McPherron AC, Lee SJ |title=GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. |journal=J. Biol. Chem. |volume=268 |issue= 5 |pages= 3444–9 |year= 1993 |pmid= 8429021 |doi=
*cite journal | author=Dong J, Albertini DF, Nishimori K, "et al." |title=Growth differentiation factor-9 is required during early ovarian folliculogenesis. |journal=Nature |volume=383 |issue= 6600 |pages= 531–5 |year= 1996 |pmid= 8849725 |doi= 10.1038/383531a0
*cite journal | author=Aaltonen J, Laitinen MP, Vuojolainen K, "et al." |title=Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 8 |pages= 2744–50 |year= 1999 |pmid= 10443672 |doi=
*cite journal | author=Gilboa L, Nohe A, Geissendörfer T, "et al." |title=Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. |journal=Mol. Biol. Cell |volume=11 |issue= 3 |pages= 1023–35 |year= 2000 |pmid= 10712517 |doi=
*cite journal | author=Vitt UA, Mazerbourg S, Klein C, Hsueh AJ |title=Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9. |journal=Biol. Reprod. |volume=67 |issue= 2 |pages= 473–80 |year= 2003 |pmid= 12135884 |doi=
*cite journal | author=Liao WX, Moore RK, Otsuka F, Shimasaki S |title=Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3713–9 |year= 2003 |pmid= 12446716 |doi= 10.1074/jbc.M210598200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liao WX, Moore RK, Shimasaki S |title=Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17391–6 |year= 2004 |pmid= 14970198 |doi= 10.1074/jbc.M401050200
*cite journal | author=Schmutz J, Martin J, Terry A, "et al." |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268–74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919
*cite journal | author=Goehler H, Lalowski M, Stelzl U, "et al." |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Dixit H, Rao LK, Padmalatha V, "et al." |title=Mutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure. |journal=Menopause (New York, N.Y.) |volume=12 |issue= 6 |pages= 749–54 |year= 2007 |pmid= 16278619 |doi= 10.1097/01.gme.0000184424.96437.7a
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Laissue P, Christin-Maitre S, Touraine P, "et al." |title=Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. |journal=Eur. J. Endocrinol. |volume=154 |issue= 5 |pages= 739–44 |year= 2006 |pmid= 16645022 |doi= 10.1530/eje.1.02135
*cite journal | author=Palmer JS, Zhao ZZ, Hoekstra C, "et al." |title=Novel variants in growth differentiation factor 9 in mothers of dizygotic twins. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 11 |pages= 4713–6 |year= 2007 |pmid= 16954162 |doi= 10.1210/jc.2006-0970
*cite journal | author=Chand AL, Ponnampalam AP, Harris SE, "et al." |title=Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure. |journal=Fertil. Steril. |volume=86 |issue= 4 |pages= 1009–12 |year= 2006 |pmid= 17027369 |doi= 10.1016/j.fertnstert.2006.02.107
*cite journal | author=Kovanci E, Rohozinski J, Simpson JL, "et al." |title=Growth differentiating factor-9 mutations may be associated with premature ovarian failure. |journal=Fertil. Steril. |volume=87 |issue= 1 |pages= 143–6 |year= 2007 |pmid= 17156781 |doi= 10.1016/j.fertnstert.2006.05.079
*cite journal | author=Hanavadi S, Martin TA, Watkins G, "et al." |title=The role of growth differentiation factor-9 (GDF-9) and its analog, GDF-9b/BMP-15, in human breast cancer. |journal=Ann. Surg. Oncol. |volume=14 |issue= 7 |pages= 2159–66 |year= 2007 |pmid= 17453295 |doi= 10.1245/s10434-007-9397-5

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Growth differentiation factor — Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development.cite journal |author=Herpin A, Lelong C, Favrel P |title=Transforming… …   Wikipedia

  • Growth factor — The term growth factor refers to a naturally occurring protein capable of stimulating cellular growth, [DorlandsDict|three/000038554|growth factor] proliferation and cellular differentiation. Growth factors are important for regulating a variety… …   Wikipedia

  • Fibroblast growth factor — Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin binding proteins and interactions with cell surface associated heparan sulfate… …   Wikipedia

  • Transforming growth factor beta superfamily — Pfam box Symbol = TGF beta Name = Transforming growth factor beta like domain width = caption = Pfam= PF00019 InterPro= IPR001839 SMART= PROSITE= PDOC00223 SCOP = 1tfg TCDB = OPM family= OPM protein= PDB=PDB3|1ktzA:312 412 PDB3|1tgjA:312 412… …   Wikipedia

  • Differentiation-inducing factor — (DIF) is one of a class of effector molecules that induce changes in cell chemistry, inhibiting growth and promoting differentiation of cell type. DIFs 1 3 are chlorinated hexaphenones (phenylalkan 1 ones, with chloro, hydroxy and methoxy… …   Wikipedia

  • Factor de transcripción asociado con microftalmia — HUGO 7105 Símbolo MITF Símbolos alt. WS2A …   Wikipedia Español

  • factor — 1. One of the contributing causes in any action. 2. One of the components that by multiplication makes up a number or expression. 3. SYN: gene. 4. A vitamin or other essential element. 5. An event, characteristic, or other definable entity that …   Medical dictionary

  • growth — /grohth/, n. 1. the act or process, or a manner of growing; development; gradual increase. 2. size or stage of development: It hasn t yet reached its full growth. 3. completed development. 4. development from a simpler to a more complex stage:… …   Universalium

  • Differentiation therapy — An approach to the treatment of advanced or aggressive malignancies in which the malignant cells are treated so that they can resume the process of maturation and differentiation into mature cells. Differentiation therapy is based on the concept… …   Medical dictionary

  • Differentiation (sociology) — See articles: sociology, sociological theory, social theory, and system theory Differentiation is a term in system theory (found in sociology.) From the viewpoint of this theory, the principal feature of modern society is the increased process of …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”