Ci protein

Ci protein

Ci protein, short for Cubitus interruptus, is a zinc finger containing transcription factor[1] involved in the Hedgehog signaling pathway.[2] In the absence of a signal to the Hedgehog signaling pathway, the Ci protein is cleaved and destroyed in proteasomes. It isn't, however, completely destroyed; part of the protein survives and acts as a repressor in the nucleus, keeping genes responsive to the Hedgehog signal silent.

Contents

Degradation of Ci

The degradation of Ci protein depends on a large multiprotein complex, which contains a serine/threonine kinase of unknown function, an anchoring protein that binds to microtubules (to keep the Ci protein out of the nucleus) and an adaptor protein.[3] When the Hedgehog signaling pathway is turned on, the Ci proteolysis is suppressed and the unprocessed CI protein enters the nucleus, where it activates the transcription of its target genes.

Target genes

References

  1. ^ Von Ohlen T, Lessing D, Nusse R, Hooper JE (March 1997). "Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2404–9. doi:10.1073/pnas.94.6.2404. PMC 20100. PMID 9122207. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20100. 
  2. ^ Cohen MM (November 2003). "The hedgehog signaling network". Am. J. Med. Genet. A 123 (1): 5–28. doi:10.1002/ajmg.a.20495. PMID 14556242. 
  3. ^ Jiang J (September 2002). "Degrading Ci: who is Cul-pable?". Genes Dev. 16 (18): 2315–21. doi:10.1101/gad.1027902. PMID 12231619. 
  4. ^ Hepker J, Wang QT, Motzny CK, Holmgren R, Orenic TV (January 1997). "Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes". Development 124 (2): 549–58. PMID 9053330. http://dev.biologists.org/cgi/content/abstract/124/2/549. 

External links



Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Protein folding — Protein thermodynamics redirects here. For the thermodynamics of reactions catalyzed by proteins, see Enzyme. Protein before and after folding. Protein folding is the process by which a protein structure assumes its functional shape or… …   Wikipedia

  • Protein-protein interaction — Protein protein interactions refer to the association of protein molecules and the study of these associations from the perspective of biochemistry, signal transduction and networks. The interactions between proteins are important for many… …   Wikipedia

  • Protein purification — is a series of processes intended to isolate a single type of protein from a complex mixture. Protein purification is vital for the characterisation of the function, structure and interactions of the protein of interest. The starting material is… …   Wikipedia

  • Protein (disambiguation) — Protein is a class of biomolecules composed of amino acid chains.Protein may also refer to:Biochemistry* Antifreeze protein, class of polypeptides produced by certain fish, vertebrates, plants, fungi and bacteria * Conjugated protein, protein… …   Wikipedia

  • Protein adulteration in the People's Republic of China — refers to the adulteration and contamination of several food and feed ingredients with inexpensive melamine and other compounds such as cyanuric acid, ammeline and ammelide. These adulterants can be used to inflate the apparent protein content of …   Wikipedia

  • Protein tyrosine phosphatase — Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post translational modification that can create novel… …   Wikipedia

  • Protein structure prediction — is one of the most important goals pursued by bioinformatics and theoretical chemistry. Its aim is the prediction of the three dimensional structure of proteins from their amino acid sequences, sometimes including additional relevant information… …   Wikipedia

  • Protein sequencing — Proteins are found in every cell and are essential to every biological process, protein structure is very complex: determining a protein s structure involves first protein sequencing determining the amino acid sequences of its constituent… …   Wikipedia

  • Protein S — is a vitamin K dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. FunctionThe best characterized function of Protein S is its… …   Wikipedia

  • Protein-protein interaction prediction — is a field combining bioinformatics and structural biology in an attempt to identify and catalog interactions between pairs or groups of proteins. Understanding protein protein interactions is important in investigating intracellular signaling… …   Wikipedia

  • Protein subcellular localization prediction — involves the computational prediction of where a protein resides in a cell. Prediction of protein subcellular localization is an important component of bioinformatics based prediction of protein function and genome annotation, and it can aid the… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”