Melanoma Classification and external resources
ICD-10 C43 ICD-9 172.9 ICD-O: M8720/3 OMIM 155600 DiseasesDB 7947 MedlinePlus 000850 eMedicine derm/257 med/1386 ent/27 plastic/456 MeSH D008545
Melanoma i// (from Greek μέλας - melas, "dark") is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye (see uveal melanoma). Melanoma can occur in any part of the body that contains melanocytes.
Melanoma is less common than other skin cancers. However, it is much more dangerous and causes the majority (75%) of deaths related to skin cancer. Worldwide, doctors diagnose about 160,000 new cases of melanoma yearly. The diagnosis is more frequent in women than in men and is particularly common among Caucasians living in sunny climates, with high rates of incidence in Australia, New Zealand, North America, Latin America, and northern Europe. According to a WHO report, about 48,000 melanoma related deaths occur worldwide per year.
The treatment includes surgical removal of the tumor, adjuvant treatment, chemo- and immunotherapy, or radiation therapy. The chance of a cure is greatest when the tumor is discovered while it is still small and thin, and can be entirely removed surgically.
- 1 Signs and symptoms
- 2 Cause
- 3 Diagnosis
- 4 Prevention
- 5 Treatment
- 6 Prognosis
- 7 Epidemiology
- 8 History
- 9 Research
- 10 See also
- 11 Notes
- 12 External links
Signs and symptoms
Early signs of melanoma are changes to the shape or color of existing moles or, in the case of nodular melanoma, the appearance of a new lump anywhere on the skin (such lesions should be referred without delay to a dermatologist). At later stages, the mole may itch, ulcerate or bleed. Early signs of melanoma are summarized by the mnemonic "ABCDE":
- Borders (irregular)
- Color (variegated), and
- Diameter (greater than 6 mm (0.24 in), about the size of a pencil eraser)
- Evolving over time
These classifications do not, however, apply to the most dangerous form of melanoma, nodular melanoma, which has its own classifications:
- Elevated above the skin surface
- Firm to the touch
Metastatic melanoma may cause nonspecific paraneoplastic symptoms, including loss of appetite, nausea, vomiting and fatigue. Metastasis of early melanoma is possible, but relatively rare: less than a fifth of melanomas diagnosed early become metastatic. Brain metastases are particularly common in patients with metastatic melanoma.
All cancers are caused by damage to the DNA inside cells. This damage can be inherited in the form of genetic mutations, but in most cases, it builds up over a person's lifetime and is caused by factors in their environment. DNA damage causes the cell to grow out of control, leading to a tumor. Melanoma is usually caused by damage from UV light from the sun, but UV light from sunbeds can also contribute to the disease.
The earliest stage of melanoma starts when the melanocytes begin to grow out of control. Melanocytes are found between the outer layer of the skin (the epidermis) and the next layer (the dermis). This early stage of the disease is called the radial growth phase, and the tumour is less than 1mm thick. Because the cancer cells have not yet reached the blood vessels lower down in the skin, it is very unlikely that this early-stage cancer will spread to other parts of the body. If the melanoma is detected at this stage, then it can usually be completely removed with surgery.
When the tumour cells start to move in a different direction — vertically up into the epidermis and into the papillary dermis — the behaviour of the cells changes dramatically.
The next step in the evolution is the invasive radial growth phase, which is a confusing term; however, it explains the next step in the process of the radial growth, when individual cells start to acquire invasive potential. This step is important – from this point on the melanoma is capable of spreading. The Breslow's depth of the lesion is usually less than1 mm (0.04 in), the Clark level is usually 2.
The following step in the process is the invasive melanoma — the vertical growth phase (VGP). The tumour attains invasive potential, meaning it can grow into the surrounding tissue and can spread around the body through blood or lymph vessels. The tumour thickness is usually more than 1 mm (0.04 in), and the tumour involves the deeper parts of the dermis.
The host elicits an immunological reaction against the tumour (during the VGP), which is judged by the presence and activity of the tumour infiltrating lymphocytes (TILs). These cells sometimes completely destroy the primary tumour, this is called regression, which is the latest stage of the melanoma development. In certain cases, the primary tumour is completely destroyed and only the metastatic tumour is discovered.
A number of rare mutations, which often run in families, are known to greatly increase one’s susceptibility to melanoma. Several different genes have been identified as increasing the risk of developing melanoma. Some rare genes have a relatively high risk of causing melanoma; some more common genes, such as a gene called MC1R that causes red hair, have a relatively low risk. Genetic testing can be used to determine whether a person has one of the currently known mutations.
One class of mutations affects the gene CDKN2A[disambiguation needed ]. An alternative reading frame mutation in this gene leads to the destabilization of p53, a transcription factor involved in apoptosis and in fifty percent of human cancers. Another mutation in the same gene results in a nonfunctional inhibitor of CDK4, a [cyclin-dependent kinase] that promotes cell division. Mutations that cause the skin condition xeroderma pigmentosum (XP) also seriously predispose one to melanoma. Scattered throughout the genome, these mutations reduce a cell’s ability to repair DNA. Both CDKN2A and XP mutations are highly penetrant[clarification needed].
Familial melanoma is genetically heterogeneous, and loci for familial melanoma have been identified on the chromosome arms 1p, 9p and 12q. Multiple genetic events have been related to the pathogenesis (disease development) of melanoma. The multiple tumor suppressor 1 (CDKN2A/MTS1) gene encodes p16INK4a — a low-molecular weight protein inhibitor of cyclin-dependent protein kinases (CDKs) — which has been localised to the p21 region of human chromosome 9.
Other mutations confer lower risk, but are more prevalent in the population. People with mutations in the MC1R gene, for example, are two to four times more likely to develop melanoma than those with two wild-type (typical unaffected type) copies of the gene. MC1R mutations are very common; in fact, all people with red hair have a mutated copy of the gene.
Two-gene models of melanoma risk have already been created, and in the future, researchers hope to create genome-scale models that will allow them to predict a patient’s risk of developing melanoma based on his or her genotype.
In addition to identifying high-risk patients, researchers want to identify high-risk lesions (abnormal area of tissue) within a given patient. Many new technologies, such as optical coherence tomography(OCT), are being developed to accomplish this. OCT allows pathologists to view three-dimensional reconstructions of the skin and offers more resolution than past techniques could provide. In vivo confocal microscopy and fluorescently tagged antibodies are also proving to be valuable diagnostic tools.
Mutation of the MDM2 SNP309 gene is associated with increased risk of melanoma in younger women.
In July 2009, the IARC released a report that categorized tanning beds as “carcinogenic to humans”. The agency, which is part of the World Health Organization (WHO), previously classified tanning beds as “probably carcinogenic”. The change comes after an analysis of more than 20 epidemiological studies indicating that people who begin using tanning devices before age 30 are 75% more likely to develop melanoma.
In December 2009, Julie Morgan, Labour MP for Cardiff North, introduced a Private Member's Bill before Parliament aimed at preventing under-18s using sunbeds. MPs considered the evidence, including research from a UK cancer charity. The research found that a quarter of a million children in England between the ages of 11 and 17 regularly used sunbeds. The bill was passed in April 2011; the Sunbed (Regulation) Bill restricts the use of sunbeds to over-18s in England and Wales (Scotland already had this legislation). All sunbed salons will have to be staffed and provide accurate health information on the dangers of sunbeds.
There is no blood test for detecting melanomas. Visual diagnosis of melanomas is still the most common method employed by health professionals. To detect melanomas (and increase survival rates), it is recommended to learn what they look like (see "ABCDE" mnemonic below), to be aware of moles and check for changes (shape, size, color, itching or bleeding) and to show any suspicious moles to a doctor with an interest and skills in skin malignancy.
A popular method for remembering the signs and symptoms of melanoma is the mnemonic "ABCDE":
- Asymmetrical skin lesion.
- Border of the lesion is irregular.
- Color: melanomas usually have multiple colors.
- Diameter: moles greater than 6 mm are more likely to be melanomas than smaller moles.
- Enlarging: Enlarging or evolving
A weakness in this system is the diameter. Many melanomas present themselves as lesions smaller than 6 mm in diameter; and all melanomas were malignant on day 1 of growth, which is merely a dot. An astute physician will examine all abnormal moles, including ones less than 6 mm in diameter. Seborrheic keratosis may meet some or all of the ABCD criteria, and can lead to false alarms among laypeople and sometimes even physicians. An experienced doctor can generally distinguish seborrheic keratosis from melanoma upon examination, or with dermatoscopy.
Some will advocate the system "ABCDE", with E for evolution. Certainly moles which change and evolve will be a concern. Alternatively, some will refer to E as elevation. Elevation can help identify a melanoma, but lack of elevation does not mean that the lesion is not a melanoma. Most melanomas are detected in the very early stage, or in-situ stage, before they become elevated. By the time elevation is visible, they may have progressed to the more dangerous invasive stage.
However, nodular melanomas do not fulfill these criteria, having their own mnemonic "EFG":
- Elevated: the lesion is raised above the surrounding skin.
- Firm: the nodule is solid to the touch.
- Growing: the nodule is increasing in size.
A recent and novel method of melanoma detection is the "ugly duckling sign" It is simple, easy to teach, and highly effective in detecting melanoma. Simply, correlation of common characteristics of a person's skin lesion is made. Lesions which greatly deviate from the common characteristics are labeled as an "Ugly Duckling", and further professional exam is required. The "Little Red Riding Hood" sign suggests that individuals with fair skin and light-colored hair might have difficult-to-diagnose amelanotic melanomas. Extra care and caution should be rendered when examining such individuals, as they might have multiple melanomas and severely dysplastic nevi. A dermatoscope must be used to detect "ugly ducklings", as many melanomas in these individuals resemble non-melanomas or are considered to be "wolves in sheep clothing". These fair-skinned individuals often have lightly pigmented or amelanotic melanomas which will not present easy-to-observe color changes and variation in colors. The borders of these amelanotic melanomas are often indistinct, making visual identification without a dermatoscope (dermatoscopy) very difficult.
People with a personal or family history of skin cancer or of dysplastic nevus syndrome (multiple atypical moles) should see a dermatologist at least once a year to be sure they are not developing melanoma.
Moles that are irregular in color or shape are often treated as candidates of melanoma. Following a visual examination and a dermatoscopic exam, or in vivo diagnostic tools such as a confocal microscope, the doctor may biopsy the suspicious mole. If the mole is malignant, the mole and an area around it need excision.
The diagnosis of melanoma requires experience, as early stages may look identical to harmless moles or not have any color at all. A skin biopsy performed under local anesthesia is often required to assist in making or confirming the diagnosis and in defining the severity of the melanoma. Amelanotic melanomas and melanomas arising in fair-skinned individuals (see the "Little Red Riding Hood" sign) are very difficult to detect, as they fail to show many of the characteristics in the ABCD rule, break the "Ugly Duckling" sign, and are very hard to distinguish from acne scarring, insect bites, dermatofibromas, or lentigines.
Total body photography, which involves photographic documentation of as much body surface as possible, is often used during follow-up of high-risk patients. The technique has been reported to enable early detection and provides a cost-effective approach (being possible with the use of any digital camera), but its efficacy has been questioned due to its inability to detect macroscopic changes. The diagnosis method should be used in conjunction with (and not as a replacement for) dermscopic imaging, with a combination of both methods appearing to give extremely high rates of detection. Similarly, there is a web-based technology for mole screening, which evaluates customers’ images against a ‘bank’ of known clinical results. The online-screening test is not a substitute for existing medical services, but rather, the technology uses very sophisticated state-of-the-art analysis of a digital image of a suspect mole to screen out any benign moles (the vast majority cases – over 90%), reducing the pressure on healthcare services. The standard approach to the diagnosis of Melanoma is to encourage people to look for any change in colour, size and shape of a mole following the A-B-C-D-E guidelines mentioned previously. The use of digital image analysis and structure recognition provides a machine interpretation to classify moles based on risk, and provides additional advice and support to users - both patient and professional.
Melanoma is divided into the following stereotypes:
- Lentigo maligna
- Lentigo maligna melanoma
- Superficial spreading melanoma
- Acral lentiginous melanoma
- Mucosal melanoma
- Nodular melanoma
- Polypoid melanoma
- Desmoplastic melanoma
- Amelanotic melanoma
- Soft-tissue melanoma
Lactate dehydrogenase (LDH) tests are often used to screen for metastases, although many patients with metastases (even end-stage) have a normal LDH; extraordinarily high LDH often indicates metastatic spread of the disease to the liver. It is common for patients diagnosed with melanoma to have chest X-rays and an LDH test, and in some cases CT, MRI, PET and/or PET/CT scans. Although controversial, sentinel lymph node biopsies and examination of the lymph nodes are also performed in patients to assess spread to the lymph nodes. A diagnosis of melanoma is supported by the presence of the S-100 protein marker.
Further context on cancer staging is available at TNM.
Melanoma stages: 5 year survival rates:
Stage 0: Melanoma in situ (Clark Level I), 99.9% survival
Stage I/II: Invasive melanoma, 85–99% survival
- T1a: Less than 1.00 mm primary tumor thickness, without ulceration, and mitosis < 1/mm2
- T1b: Less than 1.00 mm primary tumor thickness, with ulceration or mitoses ≥ 1/mm2
- T2a: 1.00–2.00 mm primary tumor thickness, without ulceration
Stage II: High risk melanoma, 40–85% survival
- T2b: 1.00–2.00 mm primary tumor thickness, with ulceration
- T3a: 2.00–4.00 mm primary tumor thickness, without ulceration
- T3b: 2.00–4.00 mm primary tumor thickness, with ulceration
- T4a: 4.00 mm or greater primary tumor thickness without ulceration
- T4b: 4.00 mm or greater primary tumor thickness with ulceration
Stage III: Regional metastasis, 25–60% survival
- N1: Single positive lymph node
- N2: Two to three positive lymph nodes OR regional skin/in-transit metastasis
- N3: Four positive lymph nodes OR one lymph node and regional skin/in-transit metastases
Stage IV: Distant metastasis, 9–15% survival
- M1a: Distant skin metastasis, normal LDH
- M1b: Lung metastasis, normal LDH
- M1c: Other distant metastasis OR any distant metastasis with elevated LDH
Based upon AJCC five-year survival with proper treatment
Minimizing exposure to sources of ultraviolet radiation (the sun and sunbeds), following sun protection measures and wearing sun protective clothing (long-sleeved shirts, long trousers, and broad-brimmed hats) can offer protection. In the past, use of sunscreens with a sun protection factor (SPF) rating of 50 or higher on exposed areas were recommended, as older sunscreens more effectively blocked UVA with higher SPF. Currently, newer sunscreen ingredients (avobenzone, zinc, and titanium) effectively block both UVA and UVB even at lower SPFs. However, there are questions about the ability of sunscreen to prevent melanoma. This controversy is well discussed in numerous review articles, and is rejected by most dermatologists. This correlation might be due to the confounding variable that individuals who used sunscreen to prevent burn might have a higher lifetime exposure to either UVA or UVB. See Sunscreen controversy for further references and discussions. Tanning, once believed to help prevent skin cancers, actually can lead to an increased incidence of melanomas. Even though tanning beds emit mostly UVA, which causes tanning, it by itself might be enough to induce melanomas.
A good rule of thumb for decreasing ultraviolet light exposure is to avoid the sun between the hours of 9 a.m. and 3 p.m. or avoid the sun when one's shadow is shorter than one's height. These are rough rules, however, and can vary depending on locality and individual skin cancer risk.
Almost all melanomas start with altering the color and appearance of normal-looking skin. This area may be a dark spot or an abnormal new mole. Other melanomas form from a mole or freckle that is already present in the skin. It can be difficult to distinguish between a melanoma and a normal mole. When looking for danger signs in pigmented lesions of the skin, a few simple rules are often used. The “ABCDE” list, the "ugly duckling sign", and the "red riding hood" rule are defined and discussed under the heading "Detection" earlier in this article.
“Melanoma Monday” is the kick-off of May Melanoma Month, with special activities nationally and locally. Also known as National Skin Self-Examination Day, it is when people are encouraged to examine their skin for skin cancer. Since 1985, this program has helped to detect more than 188,000 suspicious lesions, including more than 21,500 suspected melanomas.
Confirmation of the clinical diagnosis is either done with an excisional skin biopsy or a small, full-thickness sampling with a punch skin biopsy. This is usually followed up with a wider excision of the scar or tumor. Depending on the stage, a sentinel lymph node biopsy is done, as well, although controversy exists around trial evidence for this procedure. Treatment of advanced malignant melanoma is performed from a multidisciplinary approach.
Elliptical excisional biopsies are performed to excise (followed by histological analysis and Breslow scoring, and in some cases may indeed actually remove) the tumor, but further surgery is often necessary to reduce the risk of recurrence. Punch biopsies are contraindicated in suspected melanomas, for fear of seeding tumour cells and hastening the spread of the malignant cells.
Complete surgical excision with adequate surgical margins and assessment for the presence of detectable metastatic disease along with short- and long-term followup is standard. Often this is done by a wide local excision (WLE) with 1 to 2 cm margins. Melanoma-in-situ and lentigo malignas are treated with narrower surgical margins, usually 0.2 to 0.5 cm. Many surgeons consider 0.5 cm the standard of care for standard excision of melanoma-in-situ, but 0.2 cm margin might be acceptable for margin controlled surgery (Mohs surgery, or the double-bladed technique with margin control). The wide excision aims to reduce the rate of tumour recurrence at the site of the original lesion. This is a common pattern of treatment failure in melanoma. Considerable research has aimed to elucidate appropriate margins for excision with a general trend toward less aggressive treatment during the last decades.
Mohs surgery has been reported with cure rate as low as 77% and as high as 98% for melanoma-in-situ. CCPDMA and the "double scalpel" peripheral margin controlled surgery is equivalent to Mohs surgery in effectiveness on this "intra-epithelial" type of melanoma.
Melanomas which spread usually do so to the lymph nodes in the region of the tumor before spreading elsewhere. Attempts to improve survival by removing lymph nodes surgically (lymphadenectomy) were associated with many complications, but unfortunately, no overall survival benefit. Recently, the technique of sentinel lymph node biopsy has been developed to reduce the complications of lymph node surgery while allowing assessment of the involvement of nodes with tumor.
Although controversial and without prolonging survival, sentinel lymph node biopsy is often performed, especially for T1b/T2+ tumors, mucosal tumors, ocular melanoma and tumors of the limbs. A process called lymphoscintigraphy is performed in which a radioactive tracer is injected at the tumor site to localize the sentinel node(s). Further precision is provided using a blue tracer dye, and surgery is performed to biopsy the node(s). Routine H&E staining, and immunoperoxidase staining will be adequate to rule out node involvement. PCR tests on nodes, usually performed to test for entry into clinical trials, now demonstrate that many patients with a negative SLN actually had a small number of positive cells in their nodes. Alternatively, a fine-needle aspiration may be performed and is often used to test masses.
If a lymph node is positive, depending on the extent of lymph node spread, a radical lymph node dissection will often be performed. If the disease is completely resected, the patient will be considered for adjuvant therapy. Excisional skin biopsy is the management of choice. Here, the suspect lesion is totally removed with an adequate (but minimal, usually 1 or 2 mm) ellipse of surrounding skin and tissue. To avoid disruption of the local lymphatic drainage, the preferred surgical margin for the initial biopsy should be narrow (1 mm). The biopsy should include the epidermal, dermal, and subcutaneous layers of the skin. This enables the histopathologist to determine the thickness of the melanoma by microscopic examination. This is described by Breslow's thickness (measured in millimeters). However, for large lesions, such as suspected lentigo maligna, or for lesions in surgically difficult areas (face, toes, fingers, eyelids), a small punch biopsy in representative areas will give adequate information and will not disrupt the final staging or depth determination. In no circumstances should the initial biopsy include the final surgical margin (0.5 cm, 1.0 cm, or 2 cm), as a misdiagnosis can result in excessive scarring and morbidity from the procedure. A large initial excision will disrupt the local lymphatic drainage and can affect further lymphangiogram-directed lymphnode dissection. A small punch biopsy can be used at any time where for logistical and personal reasons a patient refuses more invasive excisional biopsy. Small punch biopsies are minimally invasive and heal quickly, usually without noticeable scarring.
High-risk melanomas may require adjuvant treatment. In the United States, most patients in otherwise good health will begin up to a year of high-dose interferon treatment, which has severe side effects, but may improve the patient's prognosis. This claim is not supported by all research at this time, and in Europe, interferon is usually not used outside the scope of clinical trials.
Metastatic melanomas can be detected by X-rays, CT scans, MRIs, PET and PET/CTs, ultrasound, LDH testing and photoacoustic detection.
Chemotherapy and immunotherapy
Various chemotherapy agents are used, including dacarbazine (also termed DTIC), immunotherapy (with interleukin-2 (IL-2) or interferon (IFN)), as well as local perfusion, are used by different centers. The overall success in metastatic melanoma is quite limited. IL-2 (Proleukin) is the first new therapy approved for the treatment of metastatic melanoma in 20 years. Studies have demonstrated that IL-2 offers the possibility of a complete and long-lasting remission in this disease, although only in a small percentage of patients. A number of new agents and novel approaches are under evaluation and show promise. Clinical trial participation should be considered the standard of care for metastatic melanoma.
Lentigo maligna treatment
Standard excision is still being done by most surgeons. Unfortunately, the recurrence rate is exceedingly high (up to 50%). This is due to the ill-defined visible surgical margin, and the facial location of the lesions (often forcing the surgeon to use a narrow surgical margin). The narrow surgical margin used, combined with the limitation of the standard "bread-loafing" technique of fixed tissue histology — result in a high "false negative" error rate, and frequent recurrences. Margin control (peripheral margins) is necessary to eliminate the false negative errors. If bread loafing is used, distances from sections should approach 0.1 mm to assure that the method approaches complete margin control.
Mohs surgery has been done with cure rate reported to be as low as 77%, and as high as 95% by another author. The "double scalpel" peripheral margin controlled excision method approximates the Mohs method in margin control, but requires a pathologist intimately familiar with the complexity of managing the vertical margin on the thin peripheral sections and staining methods.
Some melanocytic nevi, and melanoma-in-situ (lentigo maligna) have resolved with an experimental treatment, imiquimod (Aldara) topical cream, an immune enhancing agent. Some dermasurgeons are combining the 2 methods: surgically excising the cancer and then treating the area with Aldara cream postoperatively for three months.
Radiation therapy is often used after surgical resection for patients with locally or regionally advanced melanoma or for patients with unresectable distant metastases. It may reduce the rate of local recurrence but does not prolong survival. Radioimmunotherapy of metastatic melanoma is currently under investigation. Radiotherapy has a role in the palliation of metastatic melanoma.
Features that affect prognosis are tumor thickness in millimeters (Breslow's depth), depth related to skin structures (Clark level), type of melanoma, presence of ulceration, presence of lymphatic/perineural invasion, presence of tumor-infiltrating lymphocytes (if present, prognosis is better), location of lesion, presence of satellite lesions, and presence of regional or distant metastasis. Certain types of melanoma have worse prognoses but this is explained by their thickness. Interestingly, less invasive melanomas even with lymph node metastases carry a better prognosis than deep melanomas without regional metastasis at time of staging. Local recurrences tend to behave similarly to a primary unless they are at the site of a wide local excision (as opposed to a staged excision or punch/shave excision) since these recurrences tend to indicate lymphatic invasion.
When melanomas have spread to the lymph nodes, one of the most important factors is the number of nodes with malignancy. Extent of malignancy within a node is also important; micrometastases in which malignancy is only microscopic have a more favorable prognosis than macrometastases. In some cases micrometastases may only be detected by special staining, and if malignancy is only detectable by a rarely employed test known as the polymerase chain reaction (PCR), the prognosis is better. Macrometastases in which malignancy is clinically apparent (in some cases cancer completely replaces a node) have a far worse prognosis, and if nodes are matted or if there is extracapsular extension, the prognosis is still worse.
When there is distant metastasis, the cancer is generally considered incurable. The five year survival rate is less than 10%. The median survival is 6 to 12 months. Treatment is palliative, focusing on life-extension and quality of life. In some cases, patients may live many months or even years with metastatic melanoma (depending on the aggressiveness of the treatment). Metastases to skin and lungs have a better prognosis. Metastases to brain, bone and liver are associated with a worse prognosis.
There is not enough definitive evidence to adequately stage, and thus give a prognosis for ocular melanoma and melanoma of soft parts, or mucosal melanoma (e.g. rectal melanoma), although these tend to metastasize more easily. Even though regression may increase survival, when a melanoma has regressed, it is impossible to know its original size and thus the original tumor is often worse than a pathology report might indicate.
Generally, an individual's risk for developing melanoma depends on two groups of factors: intrinsic and environmental. "Intrinsic" factors are generally an individual's family history and inherited genotype, while the most relevant environmental factor is sun exposure.
Epidemiologic studies suggest that exposure to ultraviolet radiation (UVA and UVB) is one of the major contributors to the development of melanoma. UV radiation causes damage to the DNA of cells, typically thymine dimerization, which when unrepaired can create mutations in the cell's genes. When the cell divides, these mutations are propagated to new generations of cells. If the mutations occur in protooncogenes or tumor suppressor genes, the rate of mitosis in the mutation-bearing cells can become uncontrolled, leading to the formation of a tumor. Data from patients suggest that aberrant levels of Activating Transcription Factor in the nucleus of melanoma cells are associated with increased metastatic activity of melanoma cells; studies from mice on skin cancer tend to confirm a role for Activating Transcription Factor-2 in cancer progression. Occasional extreme sun exposure (resulting in "sunburn") is causally related to melanoma. Melanoma is most common on the back in men and on legs in women (areas of intermittent sun exposure). The risk appears to be strongly influenced by socio-economic conditions rather than indoor versus outdoor occupations; it is more common in professional and administrative workers than unskilled workers. Other factors are mutations in or total loss of tumor suppressor genes. Use of sunbeds (with deeply penetrating UVA rays) has been linked to the development of skin cancers, including melanoma.
Possible significant elements in determining risk include the intensity and duration of sun exposure, the age at which sun exposure occurs, and the degree of skin pigmentation. Exposure during childhood is a more important risk factor than exposure in adulthood. This is seen in migration studies in Australia where people tend to retain the risk profile of their country of birth if they migrate to Australia as an adult. Individuals with blistering or peeling sunburns (especially in the first twenty years of life) have a significantly greater risk for melanoma. This does not mean that sunburn is the cause of melanoma. Instead it is merely statistically correlated. The cause is the exaggerated UV-exposure. It has been shown that sunscreen — while preventing the sunburn — does not protect mice, injected with melanoma cells a day after UV exposure, from developing melanoma.
A family history of melanoma greatly increases a person's risk because mutations in CDKN2A[disambiguation needed ], CDK4 and several other genes have been found in melanoma-prone families. Patients with a history of one melanoma are at increased risk of developing a second primary tumour.
The incidence of melanoma has increased in the recent years, but it is not clear to what extent changes in behavior, in the environment, or in early detection are involved.
To understand how sunscreen can reduce sunburn and at the same time cause melanoma it is necessary to distinguish between direct DNA damage and indirect DNA damage. Genetic analysis has shown that 92% of all melanoma are caused by the indirect DNA damage. Although some people believe that dark-skinned people such as those of African descent cannot get sunburns, they are in fact susceptible, and should use sunscreen accordingly, as sunscreen has been proven to protect against other cancers such as squamous cell carcinoma and basal cell carcinoma.
Although melanoma is not a new disease, evidence for its occurrence in antiquity is rather scarce. However, one example lies in a 1960s examination of nine Peruvian mummies, radiocarbon dated to be approximately 2400 years old, which showed apparent signs of melanoma: melanotic masses in the skin and diffuse metastases to the bones.
John Hunter is reported to be the first to operate on metastatic melanoma in 1787. Although not knowing precisely what it was, he described it as a "cancerous fungous excrescence". The excised tumor was preserved in the Hunterian Museum of the Royal College of Surgeons of England. It was not until 1968 that microscopic examination of the specimen revealed it to be an example of metastatic melanoma.
The French physician René Laennec was the first to describe melanoma as a disease entity. His report was initially presented during a lecture for the Faculté de Médecine de Paris in 1804 and then published as a bulletin in 1806. The first English language report of melanoma was presented by an English general practitioner from Stourbridge, William Norris in 1820. In his later work in 1857 he remarked that there is a familial predisposition for development of melanoma (Eight Cases of Melanosis with Pathological and Therapeutical Remarks on That Disease).
The first formal acknowledgment of advanced melanoma as untreatable came from Samuel Cooper in 1840. He stated that the only chance for benefit depends upon the early removal of the disease ...' More than one and a half centuries later this situation remains largely unchanged.
One important pathway in melanin synthesis involves the transcription factor MITF. The MITF gene is highly conserved and is found in people, mice, birds, and even fish. MITF production is regulated via a fairly straightforward pathway. UV radiation causes increased expression of transcription factor p53 in keratinocytes, and p53 causes these cells to produce melanocyte-stimulating hormone (MSH), which binds to melanocortin 1 receptors (MC1R) on melanocytes. Ligand-binding at MC1R receptors activates adenylate cyclases, which produce cAMP, which activates CREB, which promote MITF expression. The targets of MITF include p16 (a CDK inhibitor) and Bcl2, a gene essential to melanocyte survival. It is often difficult to design drugs that interfere with transcription factors, but perhaps new drugs will be discovered that can impede some reaction in the pathway upstream of MITF.
Studies of chromatin structure also promise to shed light on transcriptional regulation in melanoma cells. It has long been assumed that nucleosomes are positioned randomly on DNA, but murine studies of genes involved in melanin production now suggest that nucleosomes are stereotypically positioned on DNA. When a gene is undergoing transcription, its transcription start site is almost always nucleosome-free. When the gene is silent, however, nucleosomes often block the transcriptional start site, suggesting that nucleosome position may play a role in gene regulation.
Finally, given the fact that melanin helps protect skin cells from UV-induced damage, new melanoma prevention strategies could involve attempts to induce melanin synthesis in individuals who would otherwise get sunburns. Redheads, for example, do not tan because they have MC1R mutations. In mice, it has been shown that the melanin production pathway can be rescued downstream of MC1R.
A study published on January 27, 2011, by M. Raza Zaidi et al. shows that interferon-γ links ultraviolet radiation to melanomagenesis in mice. Using a mouse model that allowed the visual tracking and purification of melanocytes using a green fluorescent dye, data showed that UVB-induced, macrophage-enhanced interferon-γ release results in melanoma growth, proliferation and immunoevasion. Based on these results, the interferon-γ pathway can potentially serve as part of new therapeutic measures to treat patients suffering from malignant melanoma, as well as a potential preventive strategy against UV-induced radiation.
About 60% of melanomas contain a mutation in the B-Raf gene. Early clinical trials suggested that B-Raf inhibitors including Plexxicon(R)'s vemurafenib could lead to substantial tumor regression in a majority of patients if their tumor contain the B-Raf mutation. In June 2011, a large clinical trial confirmed the positive findings from those earlier trials.
At the American Society of Clinical Oncology Conference in June 2010, pharmaceutical company reported the clinical findings of their drug ipilimumab. The study found an increase in median survival from 6.4 to 10 months in patients with advanced melanomas treated with the monoclonal ipilimumab, versus an experimental vaccine. It also found a one year survival rate of 25% in the control group using the vaccine, 44% in the vaccine and ipilimumab group, and 46% in the group treated with ipilimumab alone. However, some have raised concerns about this study for its use of the unconventional control arm, rather than comparing the drug against a placebo or standard treatment. Meaning that the drug performed better than the vaccine, although the vaccine has not been tested before and may be causing toxicity — making the drug appear better by comparison.
In June 2011, a clinical trial of ipilimumab plus dacarbazine, combined this immune system booster with the standard chemotherapy drug that targets cell division. It showed an increase in median survival for these late stage patients to 11 months instead of the 9 months normally seen. Researchers were also hopeful that perhaps 10-20% of patients could live a long time. Some serious side-effects of revving up the immune system were seen in some patients. A course of treatment costs $120,000. The drug's brandname is Yervoy.
In clinical research setting other therapies, such as adoptive cell therapy or gene therapy, may be tested. Two kinds of experimental treatments developed at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) in the US have been used in advanced (metastatic) melanoma with high success rates in terms of melanoma treatments. The first treatment involves Adoptive Cell Therapy (ACT) using TILs immune cells (Tumor Infiltrating Lymphocytes) isolated from a patient's own melanoma tumor. These cells are grown in large numbers in a laboratory and returned to the patient after a treatment that temporarily reduces normal T cells in the patient's body. TIL Therapy following lymphodepletion can result in durable complete response in a variety of setups. Up to date, the only medical center outside the USA managed to successfully implement this technology is Sheba Medical Center through "Ella Institute of Melanoma", found in Israel (objective response rates of 50%). The second treatment, adoptive transfer of genetically altered autologous lymphocytes, depends on delivering genes that encode so called T cell receptors (TCRs), into patient's lymphocytes. After that manipulation lymphocytes recognize and bind to certain molecules found on the surface of melanoma cells and kill them.
Advances in high resolution ultrasound scanning have enabled surveillance of metastatic burden to the sentinel lymph nodes. The Screening and Surveillance of Ultrasound in Melanoma trial (SUNMEL) is evaluating ultrasound as an alternative to invasive surgical methods.
- List of cutaneous conditions
- Seborrheic keratosis looks like melanoma but is benign
- Spitz nevus
- Melanotropin receptor
- Slip-Slop-Slap An Australian health campaign
- Basal cell carcinoma type of non-melanoma skin cancer
- Squamous cell carcinoma type of non-melanoma skin cancer
- ^ μέλας, Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus
- ^ Jerant AF, Johnson JT, Sheridan CD, Caffrey TJ (July 2000). "Early detection and treatment of skin cancer". Am Fam Physician 62 (2): 357–68, 375–6, 381–2. PMID 10929700. http://www.aafp.org/afp/20000715/357.html.
- ^ Parkin D, Bray F, Ferlay J, Pisani P (2005). "Global cancer statistics, 2002". CA Cancer J Clin 55 (2): 74–108. doi:10.3322/canjclin.55.2.74. PMID 15761078. http://caonline.amcancersoc.org/cgi/content/full/55/2/74.
- ^ Lucas, Robyn; McMichael, Tony; Smith, Wayne; Armstrong, Bruce (2006) (PDF). Solar Ultraviolet Radiation: Global burden of disease from solar ultraviolet radiation. Environmental Burden of Disease Series. 13. World Health Organization. ISBN 92 4 159440 3. http://www.who.int/uv/health/solaruvradfull_180706.pdf.
- ^ MelanomaWarningSigns.com
- ^ Fiddler IJ (October 1995). "Melanoma Metastasis". Cancer Control 2 (5): 398–404. PMID 10862180. http://www.moffitt.usf.edu/pubs/ccj/v2n5/article3.html.
- ^ Solar and ultraviolet radiation. IARC Monographs on the evaluation of carcinogenic risks to humans. 55. 1992. http://monographs.iarc.fr/ENG/Monographs/vol55/.
- ^ a b Hershkovitz L, Schachter J, Treves AJ, Besser MJ (2010). "Focus on adoptive T cell transfer trials in melanoma". Clin. Dev. Immunol. 2010: 260267. doi:10.1155/2010/260267. PMC 3018069. PMID 21234353. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3018069.
- ^ "ASCO Annual Meeting Proceedings Part I. Abstract: Protective effect of a brisk tumor infiltrating lymphocyte infiltrate in melanoma: An EORTC melanoma group study". Journal of Clinical Oncology 25 (18S): 8519. 2007. http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=47&abstractID=34439.
- ^ Greene MH. (1998). "The genetics of hereditary melanoma and nevi". Cancer 86 (11): 2464–77. doi:10.1002/(SICI)1097-0142(19991201)86:11. PMID 10630172.
- ^ Halachmi S, Gilchrest BA. (2001). "Update on genetic events in the pathogenesis of melanoma". Curr Opin Oncol 13 (2): 129–136. doi:10.1097/00001622-200103000-00008. PMID 11224711.
- ^ CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) from Entrez Gene
- ^ Firoz, EF; Warycha, M; Zakrzewski, J; Pollens, D; Wang, G; Shapiro, R; Berman, R; Pavlick, A et al. (2009). "Association of MDM2 SNP309, Age of Onset, and Gender in Cutaneous Melanoma.". Clinical cancer research : an official journal of the American Association for Cancer Research 15 (7): 2573–80. doi:10.1158/1078-0432.CCR-08-2678. PMID 19318491. http://clincancerres.aacrjournals.org/cgi/content/abstract/1078-0432.CCR-08-2678v1.
- ^ WHO International Agency for Research on Cancer Monograph Working Group (August 2009). "A Review of Human Carcinogens—Part D:Radiation". The Lancet Oncology 10 (8): 751–2. doi:10.1016/S1470-2045(09)70213-X. PMID 19655431.
- ^ Thomson, C; Woolnough, S, Wickenden, M, Hiom, S, Twelves, C (2010). British Medical Journal. http://www.bmj.com/content/340/bmj.c877.full.
- ^ http://www.publications.parliament.uk/pa/ld200910/ldbills/047/10047.1-6.html
- ^ a b Wurm EM, Soyer HP (October 2010). "Scanning for melanoma". Australian Prescriber (33): 150–5. http://www.australianprescriber.com/magazine/33/5/150/5.
- ^ MelanomaFoundation.org
- ^ Friedman R, Rigel D, Kopf A (1985). "Early detection of malignant melanoma: the role of physician examination and self-examination of the skin". CA Cancer J Clin 35 (3): 130–51. doi:10.3322/canjclin.35.3.130. PMID 3921200.
- ^ AAD.org
- ^ SkinCancer.org
- ^ a b Mascaro JM, Mascaro JM (November 1998). "The dermatologist's position concerning nevi: a vision ranging from "the ugly duckling" to "little red riding hood"". Arch Dermatol 134 (11): 1484–5. doi:10.1001/archderm.134.11.1484. PMID 9828892. http://archderm.ama-assn.org/cgi/pmidlookup?view=long&pmid=9828892.
- ^ a b Dermnetnz.org
- ^ Blackledge J, Dubovitski D (2011 ). "MoleTest: A Web-based Skin Cancer Screening System". Intensive 2011: The Third International Conference on Resource Intensive Applications and Services: 22–29.
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. pp. 694–9. ISBN 0-7216-2921-0.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ Malignant Melanoma: staging at Collaborative Hypertext of Radiology
- ^ a b Balch C, Buzaid A, Soong S, Atkins M, Cascinelli N, Coit D, Fleming I, Gershenwald J, Houghton A, Kirkwood J, McMasters K, Mihm M, Morton D, Reintgen D, Ross M, Sober A, Thompson J, Thompson J (2001). "Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma". J Clin Oncol 19 (16): 3635–48. PMID 11504745. http://www.jco.org/cgi/content/full/19/16/3635.
- ^ Autier P (2005). "Cutaneous malignant melanoma: facts about sunbeds and sunscreen". Expert Rev Anticancer Ther 5 (5): 821–33. doi:10.1586/1473722.214.171.1241. PMID 16221052.
- ^ Can Melanoma Be Prevented?
- ^ Garland C, Garland F, Gorham E (1992). "Could sunscreens increase melanoma risk?". Am J Public Health 82 (4): 614–5. doi:10.2105/AJPH.82.4.614. PMC 1694089. PMID 1546792. http://www.ajph.org/cgi/reprint/82/4/614.
- ^ "Does sunscreen cause melanoma? Researchers now strongly say no". J Drugs Dermatol 3 (3): 323–4. 2004. PMID 15176171. http://findarticles.com/p/articles/mi_m0PDG/is_3_3/ai_n6056512.
- ^ Clough-Gorr KM, Titus-Ernstoff L, Perry AE, Spencer SK, Ernstoff MS (September 2008). "Exposure to sunlamps, tanning beds, and melanoma risk". Cancer Causes Control 19 (7): 659–69. doi:10.1007/s10552-008-9129-6. PMID 18273687.
- ^ melanomamonday.com
- ^ http://www.malignant-melanoma.org/sentinel-node-biopsy/sentinel-node-biopsy-false-positivity/
- ^ LabPath.com
- ^ Clark GS, Pappas-Politis EC, Cherpelis BS, et al. (July 2008). "Surgical management of melanoma in situ on chronically sun-damaged skin" (PDF). Cancer Control 15 (3): 216–24. PMID 18596673. http://www.moffitt.org/CCJRoot/v15n3/pdf/216.pdf.
- ^ Balch C, Urist M, Karakousis C, Smith T, Temple W, Drzewiecki K, Jewell W, Bartolucci A, Mihm M, Barnhill R (1993). "Efficacy of 2-cm surgical margins for intermediate-thickness melanomas (1 to 4 mm). Results of a multi-institutional randomized surgical trial". Ann Surg 218 (3): 262–7; discussion 267–9. doi:10.1097/00000658-199309000-00005. PMC 1242959. PMID 8373269. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1242959.
- ^ a b Mikhail, G. Mohs Micrographic Surgery. 1991, Saunders, pp. 13–14
- ^ a b Bene NI, Healy C, Coldiron BM (May 2008). "Mohs micrographic surgery is accurate 95.1% of the time for melanoma in situ: a prospective study of 167 cases". Dermatol Surg 34 (5): 660–4. doi:10.1111/j.1524-4725.2007.34124.x. PMID 18261099. http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1076-0512&date=2008&volume=34&issue=5&spage=660. "Cure rate as high as 98% for small melanoma in situ, and as high as 95% noted for lentigo maligna variant of melanona in situ has been reported with Mohs surgery."
- ^ Malignant-Melanoma.org
- ^ Swanson N, Lee K, Gorman A, Lee H (2002). "Biopsy techniques. Diagnosis of melanoma". Intensive 2011: The Third International Conference on Resource Intensive Applications and Services 20 (4): 677–80. doi:10.1016/S0733-8635(02)00025-6. PMID 12380054.
- ^ Kirkwood J, Strawderman M, Ernstoff M, Smith T, Borden E, Blum R (1996). "Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684". J Clin Oncol 14 (1): 7–17. PMID 8558223.
- ^ Kirkwood J, Ibrahim J, Sondak V, Richards J, Flaherty L, Ernstoff M, Smith T, Rao U, Steele M, Blum R (2000). "High- and low-dose interferon alfa-2b in high-risk melanoma: first analysis of intergroup trial E1690/S9111/C9190". J Clin Oncol 18 (12): 2444–58. PMID 10856105.
- ^ Kirkwood J, Ibrahim J, Sondak V, Ernstoff M, Ross M (2002). "Interferon alfa-2a for melanoma metastases". Lancet 359 (9310): 978–9. doi:10.1016/S0140-6736(02)08001-7. PMID 11918944.
- ^ Weight RM, Viator JA, Dale PS, Caldwell CW, Lisle AE. (2006). "Photoacoustic detection of metastatic melanoma cells in the human circulatory system". Opt Lett. 31 (20): 2998–3000. doi:10.1364/OL.31.002998. PMID 17001379.
- ^ Bajetta E, Del Vecchio M, Bernard-Marty C, Vitali M, Buzzoni R, Rixe O, Nova P, Aglione S, Taillibert S, Khayat D (2002). "Metastatic melanoma: chemotherapy". Semin Oncol 29 (5): 427–45. doi:10.1053/sonc.2002.35238. PMID 12407508.
- ^ Buzaid A (2004). "Management of metastatic cutaneous melanoma". Oncology (Williston Park) 18 (11): 1443–50; discussion 1457–9. PMID 15609471.
- ^ Danson S, Lorigan P (2005). "Improving outcomes in advanced malignant melanoma: update on systemic therapy". Drugs 65 (6): 733–43. doi:10.2165/00003495-200565060-00002. PMID 15819587.
- ^ Bhatia S, Tykodi SS, Thompson JA (2009). "Treatment of Metastatic Melanoma: An Overview". Oncology 23 (6): 488–96. PMC 2737459. PMID 19544689. http://www.cancernetwork.com/display/article/10165/1413720.
- ^ Johnson TM, Headington JT, Baker SR, Lowe L (November 1997). "Usefulness of the staged excision for lentigo maligna and lentigo maligna melanoma: the "square" procedure". J. Am. Acad. Dermatol. 37 (5 Pt 1): 758–64. doi:10.1016/S0190-9622(97)70114-2. PMID 9366823. http://linkinghub.elsevier.com/retrieve/pii/S0190-9622(97)70114-2.
- ^ Bastiaannet E, Beukema J, Hoekstra H (2005). "Radiation therapy following lymph node dissection in melanoma patients: treatment, outcome and complications". Cancer Treat Rev 31 (1): 18–26. doi:10.1016/j.ctrv.2004.09.005. PMID 15707701.
- ^ Primary Care Oncology. Ford. 1999.
- ^ Homsi J, Kashani-Sabet M, Messina J, Daud A (2005). "Cutaneous melanoma: prognostic factors" (PDF). Cancer Control 12 (4): 223–9. PMID 16258493. https://www.moffitt.usf.edu/pubs/ccj/v12n4/pdf/223.pdf.
- ^ "CANCERMondial (GLOBOCAN)". GLOBOCAN. 2010. http://www-dep.iarc.fr/. Retrieved 12 August 2010.
- ^ "WHO Disease and injury country estimates". World Health Organization. 2009. http://www.who.int/healthinfo/global_burden_disease/estimates_country/en/index.html. Retrieved Nov. 11, 2009.
- ^ Who is Most at Risk for Melanoma?
- ^ Wang S, Setlow R, Berwick M, Polsky D, Marghoob A, Kopf A, Bart R (2001). "Ultraviolet A and melanoma: a review". J Am Acad Dermatol 44 (5): 837–46. doi:10.1067/mjd.2001.114594. PMID 11312434.
- ^ Leslie MC, Bar-Eli M (January 2005). "Regulation of gene expression in melanoma: new approaches for treatment". J. Cell. Biochem. 94 (1): 25–38. doi:10.1002/jcb.20296. PMID 15523674.
- ^ Bhoumik A, Singha N, O'Connell MJ, Ronai ZA (June 2008). "Regulation of TIP60 by ATF2 modulates ATM activation". J. Biol. Chem. 283 (25): 17605–14. doi:10.1074/jbc.M802030200. PMC 2427333. PMID 18397884. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=18397884.
- ^ Bhoumik A, Jones N, Ronai Z (March 2004). "Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4222–7. doi:10.1073/pnas.0400195101. PMC 384722. PMID 15010535. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=15010535.
- ^ Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). "The role of ATF-2 in oncogenesis". Bioessays 30 (4): 314–27. doi:10.1002/bies.20734. PMID 18348191.
- ^ Huang Y, Minigh J, Miles S, Niles RM (2008). "Retinoic acid decreases ATF-2 phosphorylation and sensitizes melanoma cells to taxol-mediated growth inhibition". J Mol Signal 3: 3. doi:10.1186/1750-2187-3-3. PMC 2265711. PMID 18269766. http://www.jmolecularsignaling.com/content/3//3.
- ^ Oliveria S, Saraiya M, Geller A, Heneghan M, Jorgensen C (2006). "Sun exposure and risk of melanoma". Arch Dis Child 91 (2): 131–8. doi:10.1136/adc.2005.086918. PMC 2082713. PMID 16326797. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2082713.
- ^ Lee J, Strickland D (1980). "Malignant melanoma: social status and outdoor work". Br J Cancer 41 (5): 757–63. doi:10.1038/bjc.1980.138. PMC 2010319. PMID 7426301. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2010319.
- ^ Pion IA, Rigel DS, Garfinkel L, Silverman MK, Kopf AW (January 1995). "Occupation and the risk of malignant melanoma". Cancer 75 (2 Suppl): 637–44. doi:10.1002/1097-0142(19950115)75:2. PMID 7804988.
- ^ The World Health Organization recommends that no person under 18 should use a sunbed
- ^ Khlat M, Vail A, Parkin M, Green A (1992). "Mortality from melanoma in migrants to Australia: variation by age at arrival and duration of stay". Am J Epidemiol 135 (10): 1103–13. PMID 1632422.
- ^ Wolf P; Donawho C K; Kripke M L (1994). "Effect of Sunscreens on UV radiation-induced enhancements of melanoma in mice". J. Nat. Cancer. Inst. 86 (2): 99–105. doi:10.1093/jnci/86.2.99. PMID 8271307.
- ^ Bliss J, Ford D, Swerdlow A, Armstrong B, Cristofolini M, Elwood J, Green A, Holly E, Mack T, MacKie R (1995). "Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies. The International Melanoma Analysis Group (IMAGE)". Int J Cancer 62 (4): 367–76. doi:10.1002/ijc.2910620402. PMID 7635560.
- ^ Miller A, Mihm M (2006). "Melanoma". N Engl J Med 355 (1): 51–65. doi:10.1056/NEJMra052166. PMID 16822996.
- ^ Rhodes A, Weinstock M, Fitzpatrick T, Mihm M, Sober A (1987). "Risk factors for cutaneous melanoma. A practical method of recognizing predisposed individuals". JAMA 258 (21): 3146–54. doi:10.1001/jama.258.21.3146. PMID 3312689.
- ^ Berwick M, Wiggins C (2006). "The current epidemiology of cutaneous malignant melanoma". Front Biosci 11: 1244–54. doi:10.2741/1877. PMID 16368510.
- ^ Davies H.; Bignell G. R.; Cox C.; (June 2002). "Mutations of the BRAF gene in human cancer". Nature 417 (6892): 949–954. doi:10.1038/nature00766. PMID 12068308. http://www.nature.com/nature/journal/v417/n6892/full/nature00766.html.
- ^ Ulrich, Claas; A. Degen, Manisha J. Patel and Eggert Stockfleth (2008). "Sunscreens in organ transplant patients". Nephrology Dialysis Transplantation 23 (6): 1805–1808. doi:10.1093/ndt/gfn292. PMID 18492979.
- ^ Urteaga O, Pack G (1966). "On the antiquity of melanoma". Cancer 19 (5): 607–10. doi:10.1002/1097-0142(196605)19:5<607::AID-CNCR2820190502>3.0.CO;2-8. PMID 5326247.
- ^ Bodenham D (1968). "A study of 650 observed malignant melanomas in the South-West region". Ann R Coll Surg Engl 43 (4): 218–39. PMC 2312310. PMID 5698493. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2312310.
- ^ Laennec RTH (1806). "Sur les melanoses". Bulletin de la Faculte de Medecine de Paris 1: 24–26.
- ^ Norris, W. (1820). "A case of fungoid disease". Edinb. Med. Surg. J. 16: 562–5.
- ^ Cooper, Samuel (1840). First lines of theory and practice of surgery. London: Longman, Orme, Brown, Green and Longman.
- ^ Zaidi MR, Davis S, Noonan FP, et al. (January 2011). "Interferon-γ links ultraviolet radiation to melanomagenesis in mice". Nature 469 (7331): 548–53. doi:10.1038/nature09666. PMID 21248750. http://www.nature.com/nature/journal/v469/n7331/full/nature09666.html.
- ^ Harmon, Amy (February 21, 2010). "A Roller Coaster Chase for a Cure". The New York Times. http://www.nytimes.com/2010/02/22/health/research/22trial.html?.
- ^ a b Andrew Pollack (June 5, 2011). "Drugs Show Promise Slowing Advanced Melanoma". New York Times. http://www.nytimes.com/2011/06/06/health/research/06melanoma.html.
- ^ Paul B. Chapman et al (2011-06-05). "Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation". New England Journal of Medicine. doi:10.1056/NEJMoa1103782. http://www.nejm.org/doi/full/10.1056/NEJMoa1103782.
- ^ "Bristol drug cuts death risk in advanced melanoma". Reuters. June 5, 2010. http://www.reuters.com/article/idUSN0218461520100605.
- ^ http://www.pharmalot.com/2010/06/bristol-myers-melanoma-med-and-wall-street-wags/
- ^ Forbes. http://blogs.forbes.com/sciencebiz/2010/06/the-risk-for-bristol/.
- ^ http://www.news-medical.net/news/20100609/Phase-3-clinical-study-Ipilimumab-boosts-sustains-immune-system-responses-against-melanoma-tumors.aspx
- ^ Caroline Robert et al (2011-06-05). "Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma". New England Journal of Medicine. doi:10.1056/NEJMoa1104621. http://www.nejm.org/doi/full/10.1056/NEJMoa1104621.
- ^ Sotomayor M, Yu H, Antonia S, Sotomayor E, Pardoll D (2002). "Advances in gene therapy for malignant melanoma" (PDF). Cancer Control 9 (1): 39–48. PMID 11907465. https://www.moffitt.usf.edu/pubs/ccj/v9n1/pdf/39.pdf.
- ^ Dudley ME, Yang JC, Sherry R, et al. (November 2008). "Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens". J. Clin. Oncol. 26 (32): 5233–9. doi:10.1200/JCO.2008.16.5449. PMC 2652090. PMID 18809613. http://jco.ascopubs.org/content/26/32/5233.full.
- ^ a b Besser MJ, Shapira-Frommer R, Treves AJ, et al. (May 2010). "Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients". Clin. Cancer Res. 16 (9): 2646–55. doi:10.1158/1078-0432.CCR-10-0041. PMID 20406835. http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20406835.
- ^ Press release from the NIH
- ^ "Immune System Taught To Fight Melanoma". CBSNews. 30 May 2009. http://www.cbsnews.com/stories/2009/05/30/health/main5050957.shtml.
- ^ http://professional.cancerconsultants.com/oncology_melanoma_news.aspx?id=44063
- ^ Voit C, Van Akkooi AC, Schäfer-Hesterberg G, et al. (February 2010). "Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma". J. Clin. Oncol. 28 (5): 847–52. doi:10.1200/JCO.2009.25.7428. PMID 20065175. http://www.jco.org/cgi/pmidlookup?view=long&pmid=20065175.
- ^ Screening and Surveillance of Ultrasound in Melanoma trial (SUNMEL)
Diseases of the skin and appendages by morphology GrowthsPigmentedDermal and
PurpuraMacularthrombocytopenic purpura · actinic purpuraPapularIndurated
Gonadal tumors, paraganglioma, and glomus (ICD-O 8590-8719) Gonadal/
sex cord-gonadal stromal (8590-8679)
Glomus tumors (8680-8719)
tumr, epon, para
Tumors: Skin neoplasm, Nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799) MelanomaMucosal melanoma · Superficial spreading melanoma · Nodular melanoma · lentigo (Lentigo maligna/Lentigo maligna melanoma, Acral lentiginous melanoma)Amelanotic melanoma · Desmoplastic melanoma · Melanoma with features of a Spitz nevus · Melanoma with small nevus-like cells · Polypoid melanoma · Soft-tissue melanoma Nevus/
Balloon cell nevus · Dysplastic nevus/Dysplastic nevus syndrome
Wikimedia Foundation. 2010.