Acral lentiginous melanoma
- Acral lentiginous melanoma
DiseaseDisorder infobox
Name = Acral lentiginous melanoma
ICD10 = C43
ICD9 = ICD9|172.0-ICD9|173.9
ICDO = ICDO|8744|3
Acral lentiginous melanoma is a kind of lentiginous[cite journal |author=Phan A, Touzet S, Dalle S, Ronger-Savlé S, Balme B, Thomas L |title=Acral lentiginous melanoma: histopathological prognostic features of 121 cases |journal=Br. J. Dermatol. |volume=157 |issue=2 |pages=311–8 |year=2007 |month=August |pmid=17596173 |doi=10.1111/j.1365-2133.2007.08031.x |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=2007&volume=157&issue=2&spage=311] skin melanoma. It is also known as subungual melanoma. ]
It is seen on the palms, soles and under the nails.[cite journal |author=Krementz ET, Feed RJ, Coleman WP, Sutherland CM, Carter RD, Campbell M |title=Acral lentiginous melanoma. A clinicopathologic entity |journal=Ann. Surg. |volume=195 |issue=5 |pages=632–45 |year=1982 |month=May |pmid=7073361 |pmc=1352575 |doi= |url=] This is the most common form of melanoma in Asians and Blacks. The average age at diagnosis is between sixty and seventy years. It also occurs in Caucasians and in young people. This type of melanoma occurs on non hair-bearing surfaces of the body which may or may not be exposed to sunlight. It is also found on mucous membranes. It does not appear to be linked to sun exposure.]
ymptoms
Typical symptoms include:
* longitudinal tan, black, or brown streak on a finger or toe nail (melanonychia striata)
* pigmentation of proximal nail fold
* areas of dark pigmentation on palms of hands or soles of feet
Any new area of pigmentation or an existing one that shows change should be checked by a dermatologist. If caught early this type of melanoma has a similar cure rate as the other types of superficial spreading melanoma.
Histology
The microscopic hallmarks are:
* atypical melanocytes in junctional nests
* dermal invasion
* desmoplasia
* hyperplastic epidermis
Famous Cases
Bob Marley, famous reggae artist, was killed by acral lentiginous melanoma that was present under one of his toenails. This later killed him and he had a State Funeral held in Jamaica in his honor. Before his death he wrote the song Emancipation Song which speaks about "Pirates rob I" referring to Doctors (as pirates) stealing his life with their diagnosis of the cancer known as Acral Lengitinous Melanoma.Fact|date=August 2008
References
External links
* [http://www.bweems.com/alm1.html Histology]
* [http://www.gpnotebook.co.uk/cache/-1415970783.htm GP Notebook]
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