Granular cell tumor

Granular cell tumor
Classification and external resources
2-cm tumor presented as an abdominal wall mass in a middle-aged woman
ICD-10	D36.1 (ILDS D36.170)
ICD-O:	M9582/0

Histopathologic image of granular cell tumor of the skin

Granular cell tumor (also known as "Abrikossoff's tumor,"^[1] "Granular cell myoblastoma,"^[1] "Granular cell nerve sheath tumor,"^[1] "Granular cell schwannoma"^[1]) is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time. The formation of a granular cell tumor is a neoplastic process and the lesions formed are of neural derivation, as supported by immunophenotypic and ultrastructural evidence. The neoplasm can affect all parts of the body, however, the head and neck areas are affected 45% to 65% of the time. Of the head and neck cases 70% of lesions are located intraorally(tongue, oral mucosa, hard palate). The next most common location that lesions are found in the head and neck area is the larynx (10%).^[2] Granular cell tumors are also found in the internal organs, particularly in the upper aerodigestive tract. The usual presentation is of slow growing behavior, forming a polygonal accumulation of secondary lysosomes in the cytoplasm. Granular cell tumors are typically solitary and are rarely larger than three centimeters. This type of tumor has been found to be both benign and malignant, although malignancy is rare and comprises only 2% of all granular cell tumors.^[3] The primary method for treatment is surgical, not medical. Radiation and chemotherapy are not needed for benign lesions and are not effective for malignant lesions. Benign granular cell tumors have a recurrence rate of 2% to 8% when resection margins are deemed clear of tumor infiltration. When the resection margins of a benign granular cell tumor are positive for tumor infiltration the recurrence rate is increased to 20%. Malignant lesions are aggressive and difficult to eradicate with surgery and have a recurrence rate of 32%.

See also

• List of cutaneous conditions
• Glassy cell carcinoma

References

1. ^ ^{a b c d} Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1796, 1804. ISBN 1-4160-2999-0. 
2. ^ Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
3. ^ Fanburg-Smith JC, Meis-Kindblom JM, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. Jul 1998;22(7):779-94.

This Dermal and subcutaneous growths article is a stub. You can help Wikipedia by expanding it.v · Categories: Oral neoplasia Dermal and subcutaneous growths Dermal and subcutaneous growth stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Crabbit Old Woman Estadio Teodoro Mariscal Look at other dictionaries: granular cell tumor — a common, usually benign neoplasm whose cells have a granular appearance and are thought to derive from Schwann cells. It may be found anywhere in the body, but most often in the oral cavity, especially the tongue; sometimes there are multiple… …   Medical dictionary granular cell myoblastoma — see under tumor …   Medical dictionary granular cell schwannoma — see under tumor …   Medical dictionary HÑŒrthle cell tumor — a new growth of the thyroid gland composed wholly or predominantly of large cells (HÑŒrthle, or Askanazy, cells) that have abundant granular, eosinophilic cytoplasm. Such tumors are usually benign (HÑŒrthle cell adenoma) but on occasion may be… …   Medical dictionary tumor — 1. Any swelling or tumefaction. 2. SYN: neoplasm. 3. One of the four signs of inflammation (t., calor, dolor, rubor) enunciated by Celsus. [L. t., a swelling] acinar cell t. a …   Medical dictionary Squamous-cell carcinoma — Squamous cell carcinoma, NOS Classification and external resources SCC of the skin tends to arise from pre malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here). ICD 10 …   Wikipedia Basal-cell carcinoma — Classification and external resources A basal cell carcinoma ICD 10 C44 (ILDS C44.L21) ICD 9 …   Wikipedia Merkel cell carcinoma — Classification and external resources Micrograph of a Merkel cell carcinoma. H E stain. ICD 10 C …   Wikipedia Langerhans cell histiocytosis — Classification and external resources Micrograph showing a Langerhans cell histiocytosis with the characteristic reniform Langerhans cells accompanied by abundant eosinophils. H E stain …   Wikipedia Abrikosov (Abrikossoff) tumor — Abri·ko·sov (Abri·kos·soff) tumor (ah″bre kosґof) [Aleksei Ivanovich Abrikosov (or Abrikossoff), Russian pathologist, 1875–1955] see granular cell tumor, under tumor …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”