Lichen nitidus

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB = 34283
ICD10 = ICD10|L|44|1|l|40
ICD9 = ICD9|697.1
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = derm
eMedicineTopic = 232
MeshID = D017513

Lichen nitidus is a chronic inflammatory disease of unknown etiologycite journal |author=Al-Mutairi N, Hassanein A, Nour-Eldin O, Arun J |title=Generalized lichen nitidus |journal=Pediatr Dermatol |volume=22 |issue=2 |pages=158–60 |year=2005 |pmid=15804308 |doi=10.1111/j.1525-1470.2005.22215.x |url=] , characterized by 1-2mm, discrete and uniform, shiny, flat-topped, pale flesh-colored or reddish-brown papulescite book |author=Berger, Timothy G.; Odom, Richard B.; Andrews, George E.; James, William D. |title=Andrews' Diseases of the skin: clinical dermatology |publisher=W. B. Saunders |location=Philadelphia |year=2000 |pages=277–80 |isbn=0-7216-5832-6 |oclc= |doi= |accessdate=] cite book |author=Fitzpatrick, Thomas B.; Freedberg, Irwin M. |title=Fitzpatrick's dermatology in general medicine |publisher=McGraw-Hill, Health Professions Division |location=New York |year=1999 |pages=577–81 |isbn=0-07-912938-2 |oclc= |doi= |accessdate=] that may be hypopigmented in blacks, and, occasionally, minimal scaling is present or can be induced by rubbing the surface, a disease process that usually affects children and young adultscite journal |author=Soroush V, Gurevitch AW, Peng SK |title=Generalized lichen nitidus: case report and literature review |journal=Cutis |volume=64 |issue=2 |pages=135–6 |year=1999 |pmid=10467510 |doi= |url=] , and is painless and nonpruritic, though protracted pruritus may be occur.

Presentation

Linear arrangements of these papules is common (referred to as a Koebner Phenomenon), especially on the forearmscite journal |author=Maeda M |title=A case of generalized lichen nitidus with Koebner's phenomenon |journal=J. Dermatol. |volume=21 |issue=4 |pages=273–7 |year=1994 |pmid=8056902 |doi= |url=] , but may occasionally be grouped, though not confluent, on flexural areas. Generally, the initial lesions are localized, and remain so, to the chest, abdomen, glans penis, and flexor aspects of the upper extremitiescite journal |author=Do MO, Kim MJ, Kim SH, Myung KB, Choi YW |title=Generalized lichen nitidus successfully treated with narrow-band UVB phototherapy: two cases report |journal=J. Korean Med. Sci. |volume=22 |issue=1 |pages=163–6 |year=2007 |pmid=17297274 |doi= |url=http://jkms.org/contents/jkms.php?pubyear=2007&vol=22&fpage=163] ; however, less commonly, the disease process can (1) be strictly isolated to the palms and solescite journal |author=Thibaudeau A, Maillard H, Croué A, Belperron P, Avenel Audran M, Verret JL |title= [Palmoplantar lichen nitidus: a rare cause of palmoplantar hyperkeratosis.] |language=French |journal=Ann Dermatol Venereol |volume=131 |issue=8-9 |pages=822–4 |year=2004 |pmid=15505553 |doi= |url=http://www.masson.fr/masson/MDOI-AD-08-2004-131-8-9-0151-9638-101019-ART14] , presenting with many hyperkeratotic, yellow papules that may coalesce into plaques that fissure or “...sometimes a non-specific keratoderma resembling chronic eczema,” or (2) become more widespread, with papules widely distributed on the body—the extensor surfaces of the elbows, wrists, and hands, folds of the neck, submammary region in females, groin, thighs, ankles, and feet—and fusing into erythematous, minimally scaled plaques, with reddness that develops tints of violet, brown, and yellowcite journal |author=Soroush V, Gurevitch AW, Peng SK |title=Generalized lichen nitidus: case report and literature review |journal=Cutis |volume=64 |issue=2 |pages=135–6 |year=1999 |pmid=10467510 |doi= |url=] .

Pathology

The histology of lichen nitidus is significant for a "...localized granulomatous lymphohistiocytic infiltrate in an expanded dermal papilla with thinning of overlying epidermis and downward extension of the rete ridges at the lateral margin of the infiltrate, producing a typical 'claw clutching a ball' picture...."

Treatment

Generally, lichen nitidus is asymptomatic and self-limited; therefore, no treatment is required. However, if persistent pruritus is present, or the appearance “...interferes with daily activities or outlook...” topical glucocorticoids may be tried. If the disease process is symptomatic, generalized and extensive, oral glucocorticoids may be indicated. Other reported treatments include PUVA, UVA/UVB phototherapy, astemizole, acitretin, and etretinate.

References