Benign fibrous histiocytoma

Benign fibrous histiocytoma
Dermatofibroma
Classification and external resources
ICD-10 D23 (ILDS D23.L62)
ICD-9 216.9
ICD-O: M8830/0
DiseasesDB 29384
eMedicine derm/96
MeSH D018219

Benign fibrous histiocytomas (also known as "Dermal dendrocytoma,"[1] "Dermatofibroma,"[2] "Fibrous dermatofibroma,"[2] "Fibrous histiocytoma"[2]:668, "Fibroma simplex",[1] "Nodular subepidermal fibrosis",[1] and "Sclerosing hemangioma"[1]) are benign skin growths.[3]

Contents

Presentation

Dermatofibromas are hard papules (rounded bumps) that may appear in a variety of colors, usually brownish to tan. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[4] They are composed of disordered collagen laid down by fibroblasts. In rare cases, basal cell carcinoma may develop in a dermatofibroma.

They are usually found on the leg.[5]

Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[6]

Dermatofibromas occur most often in women; the male to female ratio is about 1:4.[4]

Immunohistochemical staining

Neoplasm CD34[1] Stromelysin-3[7] Factor XIIIa[8]
Dermatofibroma + + +
Dermatofibrosarcoma protuberans + - -

See also

References

  1. ^ a b c d e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ a b c Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
  3. ^ "benign fibrous histiocytoma" at Dorland's Medical Dictionary
  4. ^ a b Pierson, Joseph C.; Diane M Pierson. "Dermatofibroma". eMedicine. WebMD. http://emedicine.medscape.com/article/1056742-overview. Retrieved 2009-06-13. 
  5. ^ "dermatofibroma" at Dorland's Medical Dictionary
  6. ^ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (June 2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Archives of pathology & laboratory medicine 130 (6): 831–4. PMID 16740036. http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=130&page=831. 
  7. ^ PMID: 17596171
  8. ^ http://emedicine.medscape.com/article/1056742-overview
v · d · eConnective/soft tissue tumors and sarcomas (ICD-O 8800–9059) (C45–C49/D17–D21, 171/214–215)
Not otherwise specified (8800–8809)
Connective tissue neoplasm
Fibromatous (8810–8839)
Fibroma/fibromatosis: Aggressive infantile fibromatosis · Aponeurotic fibroma · Collagenous fibroma · Diffuse infantile fibromatosis · Familial myxovascular fibromas · Fibroma of tendon sheath · Fibromatosis colli · Infantile digital fibromatosis · Juvenile hyaline fibromatosis · Plantar fibromatosis · Pleomorphic fibroma · Oral submucous fibrosis
Histiocytoma/histiocytic sarcoma: Benign fibrous histiocytoma · Malignant fibrous histiocytoma · Atypical fibroxanthoma
Solitary fibrous tumor
Myxomatous (8840–8849)
Fibroepithelial (9000–9039)
Synovial-like (9040–9049)
Lipomatous (8850–8889)
Chondroid lipoma · Intradermal spindle cell lipoma · Pleomorphic lipoma · Benign lipoblastomatosis · Spindle cell lipoma · Hibernoma
Myomatous (8890–8929)
general: Myoma/myosarcoma
skeletal muscle: Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma (Sarcoma botryoides) · Alveolar rhabdomyosarcoma
Leiomyoma · Angioleiomyoma · Angiolipoleiomyoma · Genital leiomyoma · Leiomyosarcoma · Multiple cutaneous and uterine leiomyomatosis syndrome · Multiple cutaneous leiomyoma · Neural fibrolipoma · Solitary cutaneous leiomyoma
Complex mixed and stromal (8930–8999)
Mesothelial (9050–9059)

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)
v · d · eTumors: Skin neoplasm, dermis (C44/D23, 173/216)
Dermis
Subcutaneous
tumors
Connective and
vascular
see Template:Soft tissue tumors and sarcomas, Template:Vascular tumors, Template:Myeloid malignancy (for mastocytosis)
Other
neuro: Solitary neurofibroma · Cutaneous meningioma · Ganglioneuroma · Schwannoma · Palisaded encapsulated neuroma · Infantile neuroblastoma · Neuroma cutis
bone/cartilage: Chordoma · Extraskeletal chondroma
histiocytoma: Malignant fibrous histiocytoma · Plexiform fibrohistiocytic tumor · Progressive nodular histiocytoma
Teratoma · Adenoma sebaceum · Metastatic carcinoma · Giant cell tumor of the tendon sheath · Glomus tumor · Granular cell tumor · Carcinoid · Desmoid tumor · Neurothekeoma · Solitary angiokeratoma · Zosteriform metastasis · Keratinizing metaplasia · Epithelioid sarcoma

M: INT, SF, LCT

anat/phys/devp

noco(i/b/d/q/u/r/p/m/k/v/f)/cong/tumr(n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

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Look at other dictionaries:

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  • Dermatofibroma — A common type of benign skin tumor that is small, slow growing, typically firm, red to brown and most often on the legs. Also called a fibrous histiocytoma. They can grow up to about 1 cm (less than a half inch) in diameter. A dermatofibroma… …   Medical dictionary

  • Dermatofibrosarcoma protuberans — Classification and external resources Histopathological image of dermatofibrosarcoma protuberans. Local recurrence long after the first excision. H E stain …   Wikipedia

  • Sarcoma — Classification and external resources ICD O: M8800/3 MeSH D012509 A sarcoma (from the Greek sarx …   Wikipedia

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