Benign fibrous histiocytoma

Benign fibrous histiocytoma
Classification and external resources
ICD-10 D23 (ILDS D23.L62)
ICD-9 216.9
ICD-O: M8830/0
DiseasesDB 29384
eMedicine derm/96
MeSH D018219

Benign fibrous histiocytomas (also known as "Dermal dendrocytoma,"[1] "Dermatofibroma,"[2] "Fibrous dermatofibroma,"[2] "Fibrous histiocytoma"[2]:668, "Fibroma simplex",[1] "Nodular subepidermal fibrosis",[1] and "Sclerosing hemangioma"[1]) are benign skin growths.[3]



Dermatofibromas are hard papules (rounded bumps) that may appear in a variety of colors, usually brownish to tan. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[4] They are composed of disordered collagen laid down by fibroblasts. In rare cases, basal cell carcinoma may develop in a dermatofibroma.

They are usually found on the leg.[5]

Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[6]

Dermatofibromas occur most often in women; the male to female ratio is about 1:4.[4]

Immunohistochemical staining

Neoplasm CD34[1] Stromelysin-3[7] Factor XIIIa[8]
Dermatofibroma + + +
Dermatofibrosarcoma protuberans + - -

See also


  1. ^ a b c d e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ a b c Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
  3. ^ "benign fibrous histiocytoma" at Dorland's Medical Dictionary
  4. ^ a b Pierson, Joseph C.; Diane M Pierson. "Dermatofibroma". eMedicine. WebMD. Retrieved 2009-06-13. 
  5. ^ "dermatofibroma" at Dorland's Medical Dictionary
  6. ^ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (June 2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Archives of pathology & laboratory medicine 130 (6): 831–4. PMID 16740036. 
  7. ^ PMID: 17596171
  8. ^

Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • benign fibrous histiocytoma — any of a group of benign skin tumors found in the dermis and containing macrophages and fibroblasts. This term is variable; some authorities broadly include neoplasms such as dermatofibroma, nodular subepidermal fibrosis, and sclerosing… …   Medical dictionary

  • fibrous histiocytoma — 1. see benign fibrous h. and malignant fibrous h. 2. dermatofibroma …   Medical dictionary

  • fibrous xanthoma — benign fibrous histiocytoma …   Medical dictionary

  • benign cephalic histiocytosis — a rare, self limited skin disorder usually seen on the faces of young children, characterized by comma shaped, discolored macules and papules that contain macrophages. Some authorities consider this condition, benign fibrous histiocytoma, and… …   Medical dictionary

  • generalized eruptive histiocytoma — a rare, self limited skin disorder usually seen on the face, trunk, or proximal limbs, characterized by discolored papules that contain macrophages; some authorities consider this condition, benign fibrous histiocytoma, and juvenile… …   Medical dictionary

  • List of cutaneous conditions — This is an incomplete list, which may never be able to satisfy particular standards for completeness. You can help by expanding it with reliably sourced entries. See also: Cutaneous conditions, Category:Cutaneous conditions, and ICD 10… …   Wikipedia

  • Dermatofibroma — A common type of benign skin tumor that is small, slow growing, typically firm, red to brown and most often on the legs. Also called a fibrous histiocytoma. They can grow up to about 1 cm (less than a half inch) in diameter. A dermatofibroma… …   Medical dictionary

  • Dermatofibrosarcoma protuberans — Classification and external resources Histopathological image of dermatofibrosarcoma protuberans. Local recurrence long after the first excision. H E stain …   Wikipedia

  • Sarcoma — Classification and external resources ICD O: M8800/3 MeSH D012509 A sarcoma (from the Greek sarx …   Wikipedia

  • Soft-tissue sarcoma — Classification and external resources ICD 9 171 DiseasesDB 31472 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”