- Brenner tumour
Brenner tumors are uncommon tumors that are part of the
surface epithelial-stromal tumorgroup of ovarian neoplasms.
The majority of these tumors are
benign. However, they can be malignant.cite journal |author=Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B |title=Malignant Brenner tumour--a case report |journal=Indian J Pathol Microbiol |volume=48 |issue=2 |pages=251–2 |year=2005 |pmid=16758686 |doi=]
They are most frequently found as incidental findingscite journal |author=Green GE, Mortele KJ, Glickman JN, Benson CB |title=Brenner tumors of the ovary: sonographic and computed tomographic imaging features |journal=J Ultrasound Med |volume=25 |issue=10 |pages=1245–51; quiz 1252–4 |year=2006 |pmid=16998096 |doi= |url=http://www.jultrasoundmed.org/cgi/pmidlookup?view=long&pmid=16998096] on
pelvic examinationor at laparotomy.
Brenner tumors very rarely can occur in other locations, including
testis.cite journal |author=Caccamo D, Socias M, Truchet C |title=Malignant Brenner tumor of the testis and epididymis |journal=Arch. Pathol. Lab. Med. |volume=115 |issue=5 |pages=524–7 |year=1991 |pmid=2021324 |doi=]
On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumors can vary in size from less than 1 cm to 30 cm. Borderline and malignant Brenner tumors are possible but each are rare.
Histologically, there are nests of transitional-type epithelial cells with longitudinal nuclear grooves (
coffeebean nuclei) lying in abundant fibrous stroma.
Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumor.
It is named for Fritz Brenner, who characterized it in 1907. cite journal |author=Lamping JD, Blythe JG |title=Bilateral Brenner tumors: a case report and review of the literature |journal=Hum. Pathol. |volume=8 |issue=5 |pages=583–5 |year=1977 |pmid=903146 |doi=10.1016/S0046-8177(77)80117-2] The term "Brenner tumor" was first used by Robert Meyer, in 1932.cite book |author=Philipp, Elliot Elias; O'Dowd, Michael J. |title=The history of obstetrics and gynaecology |publisher=Parthenon |location=Carnforth, Lancs |year=2000 |pages=586 |isbn=1-85070-040-0 |oclc= |doi=]
* [http://www.medcyclopaedia.com/library/topics/volume_iv_2/b/brenner_tumour.aspx medcyclopaedia]
* [http://library.med.utah.edu/kw/human_reprod/mml/hrovt_path_screenA57.html Histology] at
University of Utah
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