Brenner tumour

Brenner tumour


Caption = Brenner tumor of ovary
DiseasesDB = 33431
ICD10 =
ICD9 = ICD9|220
ICDO = 9000
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D001948

Brenner tumors are uncommon tumors that are part of the surface epithelial-stromal tumor group of ovarian neoplasms.

The majority of these tumors are benign. However, they can be malignant.cite journal |author=Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B |title=Malignant Brenner tumour--a case report |journal=Indian J Pathol Microbiol |volume=48 |issue=2 |pages=251–2 |year=2005 |pmid=16758686 |doi=]

They are most frequently found as incidental findingscite journal |author=Green GE, Mortele KJ, Glickman JN, Benson CB |title=Brenner tumors of the ovary: sonographic and computed tomographic imaging features |journal=J Ultrasound Med |volume=25 |issue=10 |pages=1245–51; quiz 1252–4 |year=2006 |pmid=16998096 |doi= |url=] on pelvic examination or at laparotomy.

Brenner tumors very rarely can occur in other locations, including testis.cite journal |author=Caccamo D, Socias M, Truchet C |title=Malignant Brenner tumor of the testis and epididymis |journal=Arch. Pathol. Lab. Med. |volume=115 |issue=5 |pages=524–7 |year=1991 |pmid=2021324 |doi=]


On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumors can vary in size from less than 1 cm to 30 cm. Borderline and malignant Brenner tumors are possible but each are rare.

Histologically, there are nests of transitional-type epithelial cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma.

imilar conditions

Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumor.


It is named for Fritz Brenner, who characterized it in 1907. cite journal |author=Lamping JD, Blythe JG |title=Bilateral Brenner tumors: a case report and review of the literature |journal=Hum. Pathol. |volume=8 |issue=5 |pages=583–5 |year=1977 |pmid=903146 |doi=10.1016/S0046-8177(77)80117-2] The term "Brenner tumor" was first used by Robert Meyer, in 1932.cite book |author=Philipp, Elliot Elias; O'Dowd, Michael J. |title=The history of obstetrics and gynaecology |publisher=Parthenon |location=Carnforth, Lancs |year=2000 |pages=586 |isbn=1-85070-040-0 |oclc= |doi=]


External links

* [ medcyclopaedia]
* [ Histology] at University of Utah

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