Myxoid liposarcoma

Myxoid liposarcoma: Myxoid liposarcoma

Classification and external resources

ICD-O: 8852/3

OMIM 613488

MeSH D018208

A myxoid liposarcoma is a malignant adipose tissue neoplasm.

It is associated with a fusion between DDIT3 or "CHOP" (at 12q13.1-q13.2) and FUS or "TLS" (at 16p11.2) or EWS (at 22q12.2).^[1]

The specific translocation of FUS-DDIT3 is t(12;16)(q13;p11).^[2]

References

^ Forni C, Minuzzo M, Virdis E, et al. (February 2009). "Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors". Mol. Cancer Ther. 8 (2): 449–57. doi:10.1158/1535-7163.MCT-08-0848. PMID 19190116. http://mct.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19190116.

^ Göransson M, Andersson MK, Forni C, et al. (January 2009). "The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ". Oncogene 28 (2): 270–8. doi:10.1038/onc.2008.378. PMID 18850010.

v · d · eConnective/soft tissue tumors and sarcomas (ICD-O 8800–9059) (C45–C49/D17–D21, 171/214–215)

Not otherwise specified (8800–8809)
Soft tissue sarcoma · Desmoplastic small round cell tumor

Connective tissue neoplasm

Fibromatous (8810–8839)

Fibroma/fibrosarcoma: Dermatofibrosarcoma · Dermatofibrosarcoma protuberans · Desmoplastic fibroma

Fibroma/fibromatosis: Aggressive infantile fibromatosis · Aponeurotic fibroma · Collagenous fibroma · Diffuse infantile fibromatosis · Familial myxovascular fibromas · Fibroma of tendon sheath · Fibromatosis colli · Infantile digital fibromatosis · Juvenile hyaline fibromatosis · Plantar fibromatosis · Pleomorphic fibroma · Oral submucous fibrosis

Histiocytoma/histiocytic sarcoma: Benign fibrous histiocytoma · Malignant fibrous histiocytoma · Atypical fibroxanthoma

Solitary fibrous tumor

Myxomatous (8840–8849)

Myxoma/myxosarcoma (Cutaneous myxoma, Superficial acral fibromyxoma) · Angiomyxoma · Ossifying fibromyxoid tumour

Fibroepithelial (9000–9039)

Brenner tumour · Fibroadenoma · Phyllodes tumor

Synovial-like (9040–9049)

Synovial sarcoma · Clear-cell sarcoma

Lipomatous (8850–8889)

Lipoma/liposarcoma (Myelolipoma, Myxoid liposarcoma) · PEComa (Angiomyolipoma)

Chondroid lipoma · Intradermal spindle cell lipoma · Pleomorphic lipoma · Benign lipoblastomatosis · Spindle cell lipoma · Hibernoma

Myomatous (8890–8929)

general: Myoma/myosarcoma

smooth muscle: Leiomyoma/leiomyosarcoma

skeletal muscle: Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma (Sarcoma botryoides) · Alveolar rhabdomyosarcoma

Leiomyoma · Angioleiomyoma · Angiolipoleiomyoma · Genital leiomyoma · Leiomyosarcoma · Multiple cutaneous and uterine leiomyomatosis syndrome · Multiple cutaneous leiomyoma · Neural fibrolipoma · Solitary cutaneous leiomyoma

Complex mixed and stromal (8930–8999)
Adenomyoma · Pleomorphic adenoma · Mixed Müllerian tumor · Mesoblastic nephroma · Wilms' tumor · Rhabdoid tumour · Clear-cell sarcoma of the kidney · Hepatoblastoma · Pancreatoblastoma · Carcinosarcoma

Mesothelial (9050–9059)
Mesothelioma · Adenomatoid tumor

see also Template:Connective tissue

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

v · d · ePathology: chromosome abnormalities (Q90–Q99 · 758)

Autosomal

Trisomies

Down syndrome (21) · Edwards syndrome (18) · Patau syndrome (13)
Trisomy 9 · Trisomy 8/Warkany syndrome 2 (8) · Trisomy 22/Cat eye syndrome (22) · Trisomy 16

Monosomies/deletions

1q21.1 deletion syndrome/1q21.1 duplication syndrome/TAR syndrome (1) · Wolf-Hirschhorn syndrome (4) · Cri du chat/Chromosome 5q deletion syndrome (5) · Williams syndrome (7) · Jacobsen syndrome (11) · Miller–Dieker syndrome/Smith–Magenis syndrome (17) · DiGeorge syndrome (22) · 22q13 deletion syndrome (22)
genomic imprinting (Angelman syndrome/Prader–Willi syndrome (15))

Distal 18q-/Proximal 18q-

X/Y linked

Monosomy

Turner syndrome (XO)

Trisomy/tetrasomy,
other karyotypes/mosaics

Klinefelter's syndrome (47,XXY) · 48,XXYY · 48,XXXY · 49,XXXYY · 49,XXXXY

Triple X syndrome (47,XXX) · 48,XXXX · 49,XXXXX

47,XYY · 48,XYYY · 49,XYYYY

46,XX/XY

Translocations

Leukemia/lymphoma

Lymphoid

Burkitt's lymphoma t(8 MYC;14 IGH) · Follicular lymphoma t(14 IGH;18 BCL2) · Mantle cell lymphoma/Multiple myeloma t(11 CCND1:14 IGH) · Anaplastic large cell lymphoma t(2 ALK;5 NPM1) · Acute lymphoblastic leukemia

Myeloid

Philadelphia chromosome t(9 ABL; 22 BCR) · Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1) · Acute promyelocytic leukemia t(15 PML,17 RARA) · Acute megakaryoblastic leukemia t(1 RBM15;22 MKL1)

Other

Ewing's sarcoma t(11 FLI1; 22 EWS) · Synovial sarcoma t(x SYT;18 SSX) · Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB) · Myxoid liposarcoma t(12 DDIT3; 16 FUS) · Desmoplastic small round cell tumor t(11 WT1; 22 EWS) · Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)

Other
Fragile X syndrome · Uniparental disomy · XX male syndrome

Categories:
Sarcoma
Oncology stubs

Myxoid liposarcoma
Classification and external resources
ICD-O:	8852/3
OMIM	613488
MeSH	D018208

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myxoid liposarcoma — the most common form of liposarcoma, characterized by primitive mesenchymal cells in a mucopolysaccharide rich ground substance and a plexiform capillary network; lipoblasts may be scarce. It metastasizes late, if at all … Medical dictionary
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liposarcoma — A malignant neoplasm of adults that occurs especially in the retroperitoneal tissues and the thigh, usually deep in the intermuscular or periarticular planes; histologically, l. is a large tumor that may be composed of well differentiated fat… … Medical dictionary
liposarcoma — n. a rare malignant tumour of fat cells. It is most commonly found in the thigh and is rare under the age of 30 years. There are four main histological types: well differentiated, myxoid, pleomorphic, and round cell liposarcomas. Treatment is… … The new mediacal dictionary
Liposarkom — Klassifikation nach ICD 10 C49. Bösartige Neubildung sonstigen Bindegewebes und anderer Weichteilgewebe … Deutsch Wikipedia
DNA damage-inducible transcript 3 — Identifiers Symbols DDIT3; CEBPZ; CHOP; CHOP 10; CHOP10; GADD153; MGC4154 External IDs … Wikipedia
FUS — Fusion (involved in t(12;16) in malignant liposarcoma), also known as FUS, is a human gene.cite web | title = Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia
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Soft-tissue sarcoma — Classification and external resources ICD 9 171 DiseasesDB 31472 … Wikipedia
Myxoma — For the atrial subtype, see Atrial myxoma. For the virus, see Myxoma virus. Myxomatous redirects here. It is not to be confused with Myxomatosis. Myxoma Classification and external resources … Wikipedia

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Myxoid liposarcoma

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Myxoid liposarcoma

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