Trisomy 16

Trisomy 16

Trisomy 16 is a chromosomal abnormality in which there are three copies of chromosome 16 rather than two. [cite web|author=Mary Kugler, R.N. |date=2005-08-20 |url=http://rarediseases.about.com/od/chrosomedisorders/a/082104.htm |title=Chromosome 16 Disorders |work=About.com:Rare Diseases |publisher=About, Inc. | language=English |accessdate=2008-01-30 |] It is the most common chromosomal cause of miscarriage during the first trimester of pregnancy.

It is not possible for a child to be born with an extra copy of this chromosome present in all cells (called Full Trisomy 16).cite journal |last= Seller|first= MJ|authorlink= |coauthors= Fear, C; Kumar, A; Mohammed, S |title=Trisomy 16 in a mid-trimester IVF foetus with multiple abnormalities |journal= Clinical Dysmorphology |volume=13 |issue=3 |pages=187–190 |year=2004 |pmid=15194958 |doi= |issn= 196772467|oclc=196772467 |id= BL Shelfmark 3286.273700 |url=http://www.clindysmorphol.com/pt/re/mcd/abstract.00019605-200407000-00013.htm|publisher= Lippincott Williams & Wilkins| location=London]

It is possible to be born with the mosaic form.cite journal |last= Simensen |first= RJ|authorlink= |coauthors= Colby, RS; Corning, KJ |title=A prenatal counseling conundrum: mosaic trisomy 16. A case study presenting cognitive functioning and adaptive behavior |journal= Genetic Counselling |volume=14 |issue=3 |pages=331–6 |year=2003 |pmid=14577678 |doi= |issn= 1015-8146 |oclc= 210520912| id= BL Shelfmark 4111.845000|publisher= Édition médicine et hygiène|location= Geneva] cite journal |author=Langlois S, Yong PJ, Yong SL, "et al"|last= Langlois |first= S|coauthors= Yong, P J; Yong, S L; Barrett, I; Kalousek, D K; Miny, P; Exeler, R; Morris, K; Robinson, W P |title=Postnatal follow-up of prenatally diagnosed trisomy 16 mosaicism |journal=Prenatal Diagnosis |volume=26 |issue=6 |pages=548–558 |year=2006| publisher = John Wiley & Sons| location = New York |pmid=16683298 |doi=10.1002/pd.1457|issn=0197-3851|oclc=108807898|id= BL Shelfmark 6607.646000]

External links

* [http://www.trisomy16.org Disorders of Chromosome 16 Foundation]

References


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