MKL1

MKL1

Megakaryoblastic leukemia (translocation) 1, also known as MKL1, is a human gene.cite web | title = Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57591| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.cite web | title = Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57591| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Nagase T, Kikuno R, Ishikawa KI, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=
*cite journal | author=Mercher T, Coniat MB, Monni R, "et al." |title=Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 10 |pages= 5776–9 |year= 2001 |pmid= 11344311 |doi= 10.1073/pnas.101001498
*cite journal | author=Ma Z, Morris SW, Valentine V, "et al." |title=Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. |journal=Nat. Genet. |volume=28 |issue= 3 |pages= 220–1 |year= 2001 |pmid= 11431691 |doi= 10.1038/90054
*cite journal | author=Wang D, Chang PS, Wang Z, "et al." |title=Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. |journal=Cell |volume=105 |issue= 7 |pages= 851–62 |year= 2001 |pmid= 11439182 |doi=
*cite journal | author=Sasazuki T, Sawada T, Sakon S, "et al." |title=Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28853–60 |year= 2002 |pmid= 12019265 |doi= 10.1074/jbc.M203190200
*cite journal | author=Wang DZ, Li S, Hockemeyer D, "et al." |title=Potentiation of serum response factor activity by a family of myocardin-related transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 23 |pages= 14855–60 |year= 2003 |pmid= 12397177 |doi= 10.1073/pnas.222561499
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cen B, Selvaraj A, Burgess RC, "et al." |title=Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. |journal=Mol. Cell. Biol. |volume=23 |issue= 18 |pages= 6597–608 |year= 2003 |pmid= 12944485 |doi=
*cite journal | author=Selvaraj A, Prywes R |title=Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 41977–87 |year= 2004 |pmid= 14565952 |doi= 10.1074/jbc.M305679200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Du KL, Chen M, Li J, "et al." |title=Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17578–86 |year= 2004 |pmid= 14970199 |doi= 10.1074/jbc.M400961200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Selvaraj A, Prywes R |title=Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent. |journal=BMC Mol. Biol. |volume=5 |issue= |pages= 13 |year= 2005 |pmid= 15329155 |doi= 10.1186/1471-2199-5-13
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hsiao HH, Yang MY, Liu YC, "et al." |title=RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient. |journal=Am. J. Hematol. |volume=79 |issue= 1 |pages= 43–5 |year= 2005 |pmid= 15849773 |doi= 10.1002/ajh.20298
*cite journal | author=Nakagawa K, Kuzumaki N |title=Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification. |journal=Genes Cells |volume=10 |issue= 8 |pages= 835–50 |year= 2005 |pmid= 16098147 |doi= 10.1111/j.1365-2443.2005.00880.x

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