Acute myeloblastic leukemia with maturation
- Acute myeloblastic leukemia with maturation
Infobox_Disease
Name = PAGENAME
Caption = Myeloblast
DiseasesDB =
ICD10 =
ICD9 =
ICDO = ICDO|9874|3
OMIM =
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D015470
M2 is a subtype of AML (Acute Myeloid Leukemia).
It is also known as "Acute Myeloblastic Leukemia with Maturation".[cite web |url=http://www.ucsfhealth.org/adult/medical_services/cancer/leukemia/conditions/aml/signs.html |title=Acute Myeloid Leukemia - Signs and Symptoms |format= |work=] ]Cause
This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[cite journal |author=Taj AS, Ross FM, Vickers M, "et al" |title=t(8;21) myelodysplasia, an early presentation of M2 AML |journal=Br. J. Haematol. |volume=89 |issue=4 |pages=890-2 |year=1995 |pmid=7772527 |doi=] On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes.]The two different proteins that are fused together are:
*RUNX1
*ETO
References
External links
* [http://www.med-ed.virginia.edu/courses/path/innes/wcd/myeloid1.cfm Histology] at University of Virginia
* [http://pathy.med.nagoya-u.ac.jp/atlas/doc/node26.html#SECTION00413000000000000000 Images] at Nagoya University
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