Cyclic nucleotide-gated channel alpha 4

Cyclic nucleotide gated channel alpha 4
Identifiers
Symbols	CNGA4; CNCA2; CNG-4; CNG4; CNG5; CNGB2; MGC126168; MGC126169; OCNC2; OCNCBETA; OCNCb
External IDs	OMIM: 609472 MGI: 2664099 HomoloGene: 13579 GeneCards: CNGA4 Gene
Gene Ontology Molecular function • nucleotide binding • ion channel activity • intracellular cyclic nucleotide activated cation channel activity • cAMP binding Cellular component • membrane • integral to membrane • intracellular cyclic nucleotide activated cation channel complex Biological process • ion transport • sensory perception of smell • response to stimulus • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1262	233649
Ensembl	ENSG00000132259	ENSMUSG00000030897
UniProt	Q8IV77	Q3UW12
RefSeq (mRNA)	NM_001037329	NM_001033317.3
RefSeq (protein)	NP_001032406	NP_001028489.1
Location (UCSC)	Chr 11: 6.26 – 6.27 Mb	Chr 7: 112.55 – 112.56 Mb
PubMed search	[1]	[2]

Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene.^[1][2][3]

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]^[3]

See also

• Cyclic nucleotide-gated ion channel

References

1. ^ Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2901924. 
2. ^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. 
3. ^ ^{a b} "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1262. 

Further reading

• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Kelliher KR, Ziesmann J, Munger SD et al. (2003). "Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4299–304. doi:10.1073/pnas.0736071100. PMC 153087. PMID 12649326. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=153087. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Munger SD, Lane AP, Zhong H et al. (2002). "Central Role of the CNGA4 Channel Subunit in Ca2+-Calmodulin–Dependent Odor Adaptation". Science 294 (5549): 2172–5. doi:10.1126/science.1063224. PMC 2885906. PMID 11739959. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2885906. 
• Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696–701. doi:10.1073/pnas.95.8.4696. PMC 22553. PMID 9539801. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22553. 

External links

• MeSH CNGA4+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.