ACCN3

Amiloride-sensitive cation channel 3, also known as ACCN3, is a human gene.cite web | title = Entrez Gene: ACCN3 amiloride-sensitive cation channel 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9311| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.cite web | title = Entrez Gene: ACCN3 amiloride-sensitive cation channel 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9311| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ishibashi K, Marumo F |title=Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 2 |pages= 589–93 |year= 1998 |pmid= 9571199 |doi= 10.1006/bbrc.1998.8483
*cite journal | author=de Weille JR, Bassilana F, Lazdunski M, Waldmann R |title=Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. |journal=FEBS Lett. |volume=433 |issue= 3 |pages= 257–60 |year= 1998 |pmid= 9744806 |doi=
*cite journal | author=Babinski K, Lê KT, Séguéla P |title=Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. |journal=J. Neurochem. |volume=72 |issue= 1 |pages= 51–7 |year= 1999 |pmid= 9886053 |doi=
*cite journal | author=Babinski K, Catarsi S, Biagini G, Séguéla P |title=Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28519–25 |year= 2000 |pmid= 10842183 |doi= 10.1074/jbc.M004114200
*cite journal | author=Catarsi S, Babinski K, Séguéla P |title=Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF. |journal=Neuropharmacology |volume=41 |issue= 5 |pages= 592–600 |year= 2001 |pmid= 11587714 |doi=
*cite journal | author=Alvarez de la Rosa D, Zhang P, Shao D, "et al." |title=Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 4 |pages= 2326–31 |year= 2002 |pmid= 11842212 |doi= 10.1073/pnas.042688199
*cite journal | author=Anzai N, Deval E, Schaefer L, "et al." |title=The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16655–61 |year= 2002 |pmid= 11872753 |doi= 10.1074/jbc.M201087200
*cite journal | author=Chen CC, Zimmer A, Sun WH, "et al." |title=A role for ASIC3 in the modulation of high-intensity pain stimuli. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8992–7 |year= 2002 |pmid= 12060708 |doi= 10.1073/pnas.122245999
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leonard AS, Yermolaieva O, Hruska-Hageman A, "et al." |title=cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 2029–34 |year= 2003 |pmid= 12578970 |doi= 10.1073/pnas.252782799
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hruska-Hageman AM, Benson CJ, Leonard AS, "et al." |title=PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46962–8 |year= 2004 |pmid= 15317815 |doi= 10.1074/jbc.M405874200
*cite journal | author=Price MP, Thompson RJ, Eshcol JO, "et al." |title=Stomatin modulates gating of acid-sensing ion channels. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53886–91 |year= 2005 |pmid= 15471860 |doi= 10.1074/jbc.M407708200
*cite journal | author=Jones NG, Slater R, Cadiou H, "et al." |title=Acid-induced pain and its modulation in humans. |journal=J. Neurosci. |volume=24 |issue= 48 |pages= 10974–9 |year= 2005 |pmid= 15574747 |doi= 10.1523/JNEUROSCI.2619-04.2004
*cite journal | author=Su X, Li Q, Shrestha K, "et al." |title=Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator. |journal=J. Biol. Chem. |volume=281 |issue= 48 |pages= 36960–8 |year= 2007 |pmid= 17012229 |doi= 10.1074/jbc.M608002200

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