ACCN1

Amiloride-sensitive cation channel 1, neuronal (degenerin), also known as ACCN1, is a human gene.cite web | title = Entrez Gene: ACCN1 amiloride-sensitive cation channel 1, neuronal (degenerin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=40| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.cite web | title = Entrez Gene: ACCN1 amiloride-sensitive cation channel 1, neuronal (degenerin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=40| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Price MP, Snyder PM, Welsh MJ |title=Cloning and expression of a novel human brain Na+ channel. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 7879–82 |year= 1996 |pmid= 8626462 |doi=
*cite journal | author=Waldmann R, Champigny G, Voilley N, "et al." |title=The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10433–6 |year= 1996 |pmid= 8631835 |doi=
*cite journal | author=Waldmann R, Voilley N, Mattéï MG, Lazdunski M |title=The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798. |journal=Genomics |volume=37 |issue= 2 |pages= 269–70 |year= 1997 |pmid= 8921408 |doi=
*cite journal | author=García-Añoveros J, Derfler B, Neville-Golden J, "et al." |title=BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 4 |pages= 1459–64 |year= 1997 |pmid= 9037075 |doi=
*cite journal | author=Bassilana F, Champigny G, Waldmann R, "et al." |title=The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 28819–22 |year= 1997 |pmid= 9360943 |doi=
*cite journal | author=Babinski K, Catarsi S, Biagini G, Séguéla P |title=Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28519–25 |year= 2000 |pmid= 10842183 |doi= 10.1074/jbc.M004114200
*cite journal | author=Duggan A, Garcia-Anoveros J, Corey DP |title=The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5203–8 |year= 2002 |pmid= 11739374 |doi= 10.1074/jbc.M104748200
*cite journal | author=Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ |title=Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 443–50 |year= 2002 |pmid= 11802773 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Price MP, Thompson RJ, Eshcol JO, "et al." |title=Stomatin modulates gating of acid-sensing ion channels. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53886–91 |year= 2005 |pmid= 15471860 |doi= 10.1074/jbc.M407708200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Saugstad JA, Roberts JA, Dong J, "et al." |title=Analysis of the membrane topology of the acid-sensing ion channel 2a. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55514–9 |year= 2005 |pmid= 15504740 |doi= 10.1074/jbc.M411849200
*cite journal | author=Vila-Carriles WH, Kovacs GG, Jovov B, "et al." |title=Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. |journal=J. Biol. Chem. |volume=281 |issue= 28 |pages= 19220–32 |year= 2006 |pmid= 16704974 |doi= 10.1074/jbc.M603100200
*cite journal | author=Chai S, Li M, Lan J, "et al." |title=A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. |journal=J. Biol. Chem. |volume=282 |issue= 31 |pages= 22668–77 |year= 2007 |pmid= 17548344 |doi= 10.1074/jbc.M703624200
*cite journal | author=Joch M, Ase AR, Chen CX, "et al." |title=Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. |journal=Mol. Biol. Cell |volume=18 |issue= 8 |pages= 3105–18 |year= 2007 |pmid= 17553932 |doi= 10.1091/mbc.E05-11-1027

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