KCNE3

Potassium voltage-gated channel, Isk-related family, member 3, also known as KCNE3, is a human gene.cite web | title = Entrez Gene: KCNE3 potassium voltage-gated channel, Isk-related family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10008| accessdate = ]

PBB_Summary
section_title =
summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. Mutations in this gene is associated with hypokalemic periodic paralysis.cite web | title = Entrez Gene: KCNE3 potassium voltage-gated channel, Isk-related family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10008| accessdate = ] and Brugada syndrome [Delpón E, Cordeiro JM, Núñez L, Bloch Thomsen PE, Guerchicoff A, Pollevick GD, Wu Y, Kanters JK, Larsen CT, Burashnikov E, Christiansen M, Antzelevitch C Functional Effects of KCNE3 Mutation and Its Role in the Development of Brugada Syndrome Circ Arrhythmia Electrophysiol doi:10.1161/CIRCEP.107.748103 ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Abbott GW, Sesti F, Splawski I, "et al." |title=MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. |journal=Cell |volume=97 |issue= 2 |pages= 175–87 |year= 1999 |pmid= 10219239 |doi=
*cite journal | author=Schroeder BC, Waldegger S, Fehr S, "et al." |title=A constitutively open potassium channel formed by KCNQ1 and KCNE3. |journal=Nature |volume=403 |issue= 6766 |pages= 196–9 |year= 2000 |pmid= 10646604 |doi= 10.1038/35003200
*cite journal | author=Melman YF, Domènech A, de la Luna S, McDonald TV |title=Structural determinants of KvLQT1 control by the KCNE family of proteins. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6439–44 |year= 2001 |pmid= 11104781 |doi= 10.1074/jbc.M010713200
*cite journal | author=Abbott GW, Butler MH, Bendahhou S, "et al." |title=MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. |journal=Cell |volume=104 |issue= 2 |pages= 217–31 |year= 2001 |pmid= 11207363 |doi=
*cite journal | author=Dedek K, Waldegger S |title=Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract. |journal=Pflugers Arch. |volume=442 |issue= 6 |pages= 896–902 |year= 2002 |pmid= 11680623 |doi=
*cite journal | author=Abbott GW, Goldstein SA |title=Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. |journal=FASEB J. |volume=16 |issue= 3 |pages= 390–400 |year= 2002 |pmid= 11874988 |doi= 10.1096/fj.01-0520hyp
*cite journal | author=Mazhari R, Nuss HB, Armoundas AA, "et al." |title=Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. |journal=J. Clin. Invest. |volume=109 |issue= 8 |pages= 1083–90 |year= 2002 |pmid= 11956246 |doi=
*cite journal | author=Dias Da Silva MR, Cerutti JM, Arnaldi LA, Maciel RM |title=A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic hypokalemic periodic paralysis. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 4881–4 |year= 2002 |pmid= 12414843 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jurkat-Rott K, Lehmann-Horn F |title=Periodic paralysis mutation MiRP2-R83H in controls: Interpretations and general recommendation. |journal=Neurology |volume=62 |issue= 6 |pages= 1012–5 |year= 2004 |pmid= 15037716 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lundquist AL, Turner CL, Ballester LY, George AL |title=Expression and transcriptional control of human KCNE genes. |journal=Genomics |volume=87 |issue= 1 |pages= 119–28 |year= 2006 |pmid= 16303284 |doi= 10.1016/j.ygeno.2005.09.004
*cite journal | author=Panaghie G, Tai KK, Abbott GW |title=Interaction of KCNE subunits with the KCNQ1 K+ channel pore. |journal=J. Physiol. (Lond.) |volume=570 |issue= Pt 3 |pages= 455–67 |year= 2006 |pmid= 16308347 |doi= 10.1113/jphysiol.2005.100644
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Doi K, Sato T, Kuramasu T, "et al." |title=Ménière's disease is associated with single nucleotide polymorphisms in the human potassium channel genes, KCNE1 and KCNE3. |journal=ORL J. Otorhinolaryngol. Relat. Spec. |volume=67 |issue= 5 |pages= 289–93 |year= 2006 |pmid= 16374062 |doi= 10.1159/000089410
*cite journal | author=Abbott GW, Butler MH, Goldstein SA |title=Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. |journal=FASEB J. |volume=20 |issue= 2 |pages= 293–301 |year= 2006 |pmid= 16449802 |doi= 10.1096/fj.05-5070com
*cite journal | author=Lundby A, Olesen SP |title=KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. |journal=Biochem. Biophys. Res. Commun. |volume=346 |issue= 3 |pages= 958–67 |year= 2006 |pmid= 16782062 |doi= 10.1016/j.bbrc.2006.06.004
*cite journal | author=Pannaccione A, Boscia F, Scorziello A, "et al." |title=Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. |journal=Mol. Pharmacol. |volume=72 |issue= 3 |pages= 665–73 |year= 2007 |pmid= 17495071 |doi= 10.1124/mol.107.034868

External links

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