KCNJ6

Potassium inwardly-rectifying channel, subfamily J, member 6, also known as KCNJ6 or K_ir3.2, is a human gene.cite web | title = Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3763| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.cite web | title = Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3763| accessdate = ]

ee also

* G protein-coupled inwardly-rectifying potassium channel
* Inward-rectifier potassium ion channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kubo Y, Adelman JP, Clapham DE, "et al." |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11
*cite journal | author=Patil N, Cox DR, Bhat D, "et al." |title=A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. |journal=Nat. Genet. |volume=11 |issue= 2 |pages= 126–9 |year= 1995 |pmid= 7550338 |doi= 10.1038/ng1095-126
*cite journal | author=Ferrer J, Nichols CG, Makhina EN, "et al." |title=Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26086–91 |year= 1995 |pmid= 7592809 |doi=
*cite journal | author=Tsaur ML, Menzel S, Lai FP, "et al." |title=Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM. |journal=Diabetes |volume=44 |issue= 5 |pages= 592–6 |year= 1995 |pmid= 7729621 |doi=
*cite journal | author=Sakura H, Bond C, Warren-Perry M, "et al." |title=Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit. |journal=FEBS Lett. |volume=367 |issue= 2 |pages= 193–7 |year= 1995 |pmid= 7796919 |doi=
*cite journal | author=Lesage F, Duprat F, Fink M, "et al." |title=Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. |journal=FEBS Lett. |volume=353 |issue= 1 |pages= 37–42 |year= 1994 |pmid= 7926018 |doi=
*cite journal | author=Liao YJ, Jan YN, Jan LY |title=Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. |journal=J. Neurosci. |volume=16 |issue= 22 |pages= 7137–50 |year= 1996 |pmid= 8929423 |doi=
*cite journal | author=Signorini S, Liao YJ, Duncan SA, "et al." |title=Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 3 |pages= 923–7 |year= 1997 |pmid= 9023358 |doi=
*cite journal | author=Ohira M, Seki N, Nagase T, "et al." |title=Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. |journal=Genome Res. |volume=7 |issue= 1 |pages= 47–58 |year= 1997 |pmid= 9037601 |doi=
*cite journal | author=Huang CL, Jan YN, Jan LY |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. |journal=FEBS Lett. |volume=405 |issue= 3 |pages= 291–8 |year= 1997 |pmid= 9108307 |doi=
*cite journal | author=Dahmane N, Ghezala GA, Gosset P, "et al." |title=Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. |journal=Genomics |volume=48 |issue= 1 |pages= 12–23 |year= 1998 |pmid= 9503011 |doi= 10.1006/geno.1997.5146
*cite journal | author=Inanobe A, Horio Y, Fujita A, "et al." |title=Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. |journal=J. Physiol. (Lond.) |volume=521 Pt 1 |issue= |pages= 19–30 |year= 2000 |pmid= 10562331 |doi=
*cite journal | author=Hibino H, Inanobe A, Tanemoto M, "et al." |title=Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain. |journal=EMBO J. |volume=19 |issue= 1 |pages= 78–83 |year= 2000 |pmid= 10619846 |doi= 10.1093/emboj/19.1.78
*cite journal | author=Schoots O, Wilson JM, Ethier N, "et al." |title=Co-expression of human Kir3 subunits can yield channels with different functional properties. |journal=Cell. Signal. |volume=11 |issue= 12 |pages= 871–83 |year= 2000 |pmid= 10659995 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Jelacic TM, Kennedy ME, Wickman K, Clapham DE |title=Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36211–6 |year= 2000 |pmid= 10956667 |doi= 10.1074/jbc.M007087200
*cite journal | author=Chen L, Kawano T, Bajic S, "et al." |title=A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8430–5 |year= 2002 |pmid= 12034888 |doi= 10.1073/pnas.122682899
*cite journal | author=Lavine N, Ethier N, Oak JN, "et al." |title=G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46010–9 |year= 2003 |pmid= 12297500 |doi= 10.1074/jbc.M205035200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ivanina T, Rishal I, Varon D, "et al." |title=Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29174–83 |year= 2003 |pmid= 12743112 |doi= 10.1074/jbc.M304518200

External links

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