G protein-coupled inwardly-rectifying potassium channel

G protein-coupled inwardly-rectifying potassium channel

protein
Name = potassium inwardly-rectifying channel, subfamily J, member 3
caption =


width =
HGNCid = 6264
Symbol = KCNJ3
AltSymbols = Kir3.1, GIRK1, KGA
EntrezGene = 3760
OMIM = 601534
RefSeq = NM_002239
UniProt = P48549
PDB =
ECnumber =
Chromosome = 2
Arm = q
Band = 24.1
LocusSupplementaryData =
protein
Name = potassium inwardly-rectifying channel, subfamily J, member 6
caption =


width =
HGNCid = 6267
Symbol = KCNJ6
AltSymbols = KCNJ7, Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2
EntrezGene = 3763
OMIM = 600877
RefSeq = NM_002240
UniProt = P48051
PDB =
ECnumber =
Chromosome = 21
Arm = q
Band = 22.1
LocusSupplementaryData =
protein
Name = potassium inwardly-rectifying channel, subfamily J, member 9
caption =


width =
HGNCid = 6270
Symbol = KCNJ9
AltSymbols = Kir3.3, GIRK3
EntrezGene = 3765
OMIM = 600932
RefSeq = NM_004983
UniProt = Q92806
PDB =
ECnumber =
Chromosome = 1
Arm = q
Band = 23.2
LocusSupplementaryData =
protein
Name = potassium inwardly-rectifying channel, subfamily J, member 5
caption =


width =
HGNCid = 6266
Symbol = KCNJ5
AltSymbols = Kir3.4, CIR, KATP1, GIRK4
EntrezGene = 3762
OMIM = 600734
RefSeq = NM_000890
UniProt = P48544
PDB =
ECnumber =
Chromosome = 11
Arm = q
Band = 24
LocusSupplementaryData =
The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand stimulated G protein-coupled receptors (GPCRs).cite journal | author = Dascal N | title = Signalling via the G protein-activated K+ channels | journal = Cell. Signal. | volume = 9 | issue = 8 | pages = 551–73 | year = 1997 | pmid = 9429760 | issn = | doi = 10.1016/S0898-6568(97)00095-8 ] cite journal | author = Yamada M, Inanobe A, Kurachi Y | title = G protein regulation of potassium ion channels | journal = Pharmacol. Rev. | volume = 50 | issue = 4 | pages = 723–60 | year = 1998 | pmid = 9860808 | doi = | issn = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/50/4/723 ] GPCRs in turn release activated G-protein βγ subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions resulting in hyperpolarization of the cell.

ubtypes

Examples

A wide variety of G-protein coupled receptors activate GIRKs including the M2-muscarinic, A1-adenosine, α2-adrenergic, D2-dopamine, μ- δ-, and κ-opioid, 5-HT1A serotonin, somatostatin, galanin, m-Glu, GABAB, and sphingosine-1-phosphate receptors.

Examples of GIRKs include a subset of potassium channels in the heart which when activated by parasympathetic signals such as acetylcholine through M2 muscarinic receptors, causes an outward current of potassium which slows down the heart rate.cite journal | author = Kunkel MT, Peralta EG | title = Identification of domains conferring G protein regulation on inward rectifier potassium channels | journal = Cell | volume = 83 | issue = 3 | pages = 443–9 | year = 1995 | pmid = 8521474 | doi = 10.1016/0092-8674(95)90122-1 | issn = ] cite journal | author = Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE | title = Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh | journal = Ann. N. Y. Acad. Sci. | volume = 868 | issue = | pages = 386–98 | year = 1999 | pmid = 10414308 | doi = | issn = | url = http://www.annalsnyas.org/cgi/content/abstract/868/1/386 ] These are called "muscarinic potassium channels" (IKACh) and are heterotetramers comprised of two GIRK1 and two GIRK4 subunits.cite journal | author = Krapivinsky G, Gordon EA, Wickman K, Velimirović B, Krapivinsky L, Clapham DE | title = The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K+-channel proteins | journal = Nature | volume = 374 | issue = 6518 | pages = 135–41 | year = 1995 | pmid = 7877685 | doi = 10.1038/374135a0 | issn = ] cite journal | author = Corey S, Krapivinsky G, Krapivinsky L, Clapham DE | title = Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh | journal = J. Biol. Chem. | volume = 273 | issue = 9 | pages = 5271–8 | year = 1998 | pmid = 9478984 | doi = 10.1074/jbc.273.9.5271 | issn = ]

References

External links

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