KCNJ5

Potassium inwardly-rectifying channel, subfamily J, member 5, also known as KCNJ5 or K_ir3.4, is a human gene.cite web | title = Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3762| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.cite web | title = Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3762| accessdate = ]

ee also

* G protein-coupled inwardly-rectifying potassium channel
* Inward-rectifier potassium ion channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhuo ML, Huang Y, Liu DP, Liang CC |title=KATP channel: relation with cell metabolism and role in the cardiovascular system. |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 4 |pages= 751–64 |year= 2005 |pmid= 15694835 |doi= 10.1016/j.biocel.2004.10.008
*cite journal | author=Kubo Y, Adelman JP, Clapham DE, "et al." |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11
*cite journal | author=Tucker SJ, James MR, Adelman JP |title=Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24. |journal=Genomics |volume=28 |issue= 1 |pages= 127–8 |year= 1995 |pmid= 7590741 |doi= 10.1006/geno.1995.1121
*cite journal | author=Ashford ML, Bond CT, Blair TA, Adelman JP |title=Cloning and functional expression of a rat heart KATP channel. |journal=Nature |volume=370 |issue= 6489 |pages= 456–9 |year= 1994 |pmid= 8047164 |doi= 10.1038/370456a0
*cite journal | author=Ashford ML, Bond CT, Blair TA, Adelman JP |title=Cloning and functional expression of a rat heart KATP channel. |journal=Nature |volume=378 |issue= 6559 |pages= 792 |year= 1996 |pmid= 8524415 |doi= 10.1038/378792a0
*cite journal | author=Spauschus A, Lentes KU, Wischmeyer E, "et al." |title=A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels. |journal=J. Neurosci. |volume=16 |issue= 3 |pages= 930–8 |year= 1996 |pmid= 8558261 |doi=
*cite journal | author=Iizuka M, Kubo Y, Tsunenari I, "et al." |title=Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel. |journal=Recept. Channels |volume=3 |issue= 4 |pages= 299–315 |year= 1996 |pmid= 8834003 |doi=
*cite journal | author=Chan KW, Langan MN, Sui JL, "et al." |title=A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. |journal=J. Gen. Physiol. |volume=107 |issue= 3 |pages= 381–97 |year= 1996 |pmid= 8868049 |doi=
*cite journal | author=Huang CL, Jan YN, Jan LY |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. |journal=FEBS Lett. |volume=405 |issue= 3 |pages= 291–8 |year= 1997 |pmid= 9108307 |doi=
*cite journal | author=Kanzaki M, Lindorfer MA, Garrison JC, Kojima I |title=Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14733–9 |year= 1997 |pmid= 9169438 |doi=
*cite journal | author=Wischmeyer E, Döring F, Wischmeyer E, "et al." |title=Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels. |journal=Mol. Cell. Neurosci. |volume=9 |issue= 3 |pages= 194–206 |year= 1997 |pmid= 9245502 |doi= 10.1006/mcne.1997.0614
*cite journal | author=Krapivinsky G, Kennedy ME, Nemec J, "et al." |title=Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16946–52 |year= 1998 |pmid= 9642257 |doi=
*cite journal | author=Corey S, Clapham DE |title=Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27499–504 |year= 1998 |pmid= 9765280 |doi=
*cite journal | author=Kennedy ME, Nemec J, Corey S, "et al." |title=GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2571–82 |year= 1999 |pmid= 9891030 |doi=
*cite journal | author=Schoots O, Wilson JM, Ethier N, "et al." |title=Co-expression of human Kir3 subunits can yield channels with different functional properties. |journal=Cell. Signal. |volume=11 |issue= 12 |pages= 871–83 |year= 2000 |pmid= 10659995 |doi=
*cite journal | author=He C, Yan X, Zhang H, "et al." |title=Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6088–96 |year= 2002 |pmid= 11741896 |doi= 10.1074/jbc.M104851200
*cite journal | author=Ma D, Zerangue N, Raab-Graham K, "et al." |title=Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. |journal=Neuron |volume=33 |issue= 5 |pages= 715–29 |year= 2002 |pmid= 11879649 |doi=
*cite journal | author=Lavine N, Ethier N, Oak JN, "et al." |title=G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46010–9 |year= 2003 |pmid= 12297500 |doi= 10.1074/jbc.M205035200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shankar H, Murugappan S, Kim S, "et al." |title=Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. |journal=Blood |volume=104 |issue= 5 |pages= 1335–43 |year= 2004 |pmid= 15142872 |doi= 10.1182/blood-2004-01-0069

External links

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