KCNJ3

Potassium inwardly-rectifying channel, subfamily J, member 3, also known as KCNJ3 or K_ir3.1, is a human gene.cite web | title = Entrez Gene: KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3760| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.cite web | title = Entrez Gene: KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3760| accessdate = ]

ee also

* G protein-coupled inwardly-rectifying potassium channel
* Inward-rectifier potassium ion channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kubo Y, Adelman JP, Clapham DE, "et al." |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11
*cite journal | author=Stoffel M, Espinosa R, Powell KL, "et al." |title=Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism. |journal=Genomics |volume=21 |issue= 1 |pages= 254-6 |year= 1994 |pmid= 8088798 |doi= 10.1006/geno.1994.1253
*cite journal | author=Schoots O, Yue KT, MacDonald JF, "et al." |title=Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. |journal=Brain Res. Mol. Brain Res. |volume=39 |issue= 1-2 |pages= 23-30 |year= 1996 |pmid= 8804710 |doi=
*cite journal | author=Chan KW, Langan MN, Sui JL, "et al." |title=A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. |journal=J. Gen. Physiol. |volume=107 |issue= 3 |pages= 381-97 |year= 1996 |pmid= 8868049 |doi=
*cite journal | author=Liao YJ, Jan YN, Jan LY |title=Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. |journal=J. Neurosci. |volume=16 |issue= 22 |pages= 7137-50 |year= 1996 |pmid= 8929423 |doi=
*cite journal | author=Signorini S, Liao YJ, Duncan SA, "et al." |title=Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 3 |pages= 923-7 |year= 1997 |pmid= 9023358 |doi=
*cite journal | author=Huang CL, Jan YN, Jan LY |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. |journal=FEBS Lett. |volume=405 |issue= 3 |pages= 291-8 |year= 1997 |pmid= 9108307 |doi=
*cite journal | author=Schoots O, Voskoglou T, Van Tol HH |title=Genomic organization and promoter analysis of the human G-protein-coupled K+ channel Kir3.1 (KCNJ3/HGIRK1). |journal=Genomics |volume=39 |issue= 3 |pages= 279-88 |year= 1997 |pmid= 9119365 |doi= 10.1006/geno.1996.4495
*cite journal | author=Corey S, Clapham DE |title=Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27499-504 |year= 1998 |pmid= 9765280 |doi=
*cite journal | author=Kennedy ME, Nemec J, Corey S, "et al." |title=GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2571-82 |year= 1999 |pmid= 9891030 |doi=
*cite journal | author=Pabon A, Chan KW, Sui JL, "et al." |title=Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30677-82 |year= 2000 |pmid= 10889209 |doi= 10.1074/jbc.M005338200
*cite journal | author=He C, Yan X, Zhang H, "et al." |title=Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6088-96 |year= 2002 |pmid= 11741896 |doi= 10.1074/jbc.M104851200
*cite journal | author=Chen L, Kawano T, Bajic S, "et al." |title=A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8430-5 |year= 2002 |pmid= 12034888 |doi= 10.1073/pnas.122682899
*cite journal | author=Lavine N, Ethier N, Oak JN, "et al." |title=G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46010-9 |year= 2003 |pmid= 12297500 |doi= 10.1074/jbc.M205035200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ivanina T, Rishal I, Varon D, "et al." |title=Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29174-83 |year= 2003 |pmid= 12743112 |doi= 10.1074/jbc.M304518200
*cite journal | author=Shankar H, Murugappan S, Kim S, "et al." |title=Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. |journal=Blood |volume=104 |issue= 5 |pages= 1335-43 |year= 2004 |pmid= 15142872 |doi= 10.1182/blood-2004-01-0069
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Plummer HK, Dhar MS, Cekanova M, Schuller HM |title=Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. |journal=BMC Cancer |volume=5 |issue= |pages= 104 |year= 2006 |pmid= 16109170 |doi= 10.1186/1471-2407-5-104

External links

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