ACCN2

Amiloride-sensitive cation channel 2, neuronal, also known as ACCN2, is a human gene.cite web | title = Entrez Gene: ACCN2 amiloride-sensitive cation channel 2, neuronal| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=41| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.cite web | title = Entrez Gene: ACCN2 amiloride-sensitive cation channel 2, neuronal| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=41| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Corey DP, García-Añoveros J |title=Mechanosensation and the DEG/ENaC ion channels. |journal=Science |volume=273 |issue= 5273 |pages= 323–4 |year= 1996 |pmid= 8685718 |doi=
*cite journal | author=García-Añoveros J, Derfler B, Neville-Golden J, "et al." |title=BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 4 |pages= 1459–64 |year= 1997 |pmid= 9037075 |doi=
*cite journal | author=Waldmann R, Champigny G, Bassilana F, "et al." |title=A proton-gated cation channel involved in acid-sensing. |journal=Nature |volume=386 |issue= 6621 |pages= 173–7 |year= 1997 |pmid= 9062189 |doi= 10.1038/386173a0
*cite journal | author=Bassilana F, Champigny G, Waldmann R, "et al." |title=The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 28819–22 |year= 1997 |pmid= 9360943 |doi=
*cite journal | author=Bubien JK, Keeton DA, Fuller CM, "et al." |title=Malignant human gliomas express an amiloride-sensitive Na+ conductance. |journal=Am. J. Physiol. |volume=276 |issue= 6 Pt 1 |pages= C1405–10 |year= 1999 |pmid= 10362604 |doi=
*cite journal | author=Askwith CC, Cheng C, Ikuma M, "et al." |title=Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. |journal=Neuron |volume=26 |issue= 1 |pages= 133–41 |year= 2000 |pmid= 10798398 |doi=
*cite journal | author=Bässler EL, Ngo-Anh TJ, Geisler HS, "et al." |title=Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33782–7 |year= 2001 |pmid= 11448963 |doi= 10.1074/jbc.M104030200
*cite journal | author=Gunthorpe MJ, Smith GD, Davis JB, Randall AD |title=Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells. |journal=Pflugers Arch. |volume=442 |issue= 5 |pages= 668–74 |year= 2001 |pmid= 11512022 |doi=
*cite journal | author=Duggan A, Garcia-Anoveros J, Corey DP |title=The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5203–8 |year= 2002 |pmid= 11739374 |doi= 10.1074/jbc.M104748200
*cite journal | author=Ji HL, Jovov B, Fu J, "et al." |title=Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8395–405 |year= 2002 |pmid= 11748227 |doi= 10.1074/jbc.M109465200
*cite journal | author=Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ |title=Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 443–50 |year= 2002 |pmid= 11802773 |doi=
*cite journal | author=Wemmie JA, Chen J, Askwith CC, "et al." |title=The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. |journal=Neuron |volume=34 |issue= 3 |pages= 463–77 |year= 2002 |pmid= 11988176 |doi=
*cite journal | author=Berdiev BK, Xia J, Jovov B, "et al." |title=Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 45734–40 |year= 2003 |pmid= 12244121 |doi= 10.1074/jbc.M208995200
*cite journal | author=Ugawa S, Ueda T, Ishida Y, "et al." |title=Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. |journal=J. Clin. Invest. |volume=110 |issue= 8 |pages= 1185–90 |year= 2002 |pmid= 12393854 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leonard AS, Yermolaieva O, Hruska-Hageman A, "et al." |title=cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 2029–34 |year= 2003 |pmid= 12578970 |doi= 10.1073/pnas.252782799
*cite journal | author=Wemmie JA, Coryell MW, Askwith CC, "et al." |title=Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 10 |pages= 3621–6 |year= 2004 |pmid= 14988500 |doi= 10.1073/pnas.0308753101
*cite journal | author=Poirot O, Vukicevic M, Boesch A, Kellenberger S |title=Selective regulation of acid-sensing ion channel 1 by serine proteases. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38448–57 |year= 2004 |pmid= 15247234 |doi= 10.1074/jbc.M407381200
*cite journal | author=Price MP, Thompson RJ, Eshcol JO, "et al." |title=Stomatin modulates gating of acid-sensing ion channels. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53886–91 |year= 2005 |pmid= 15471860 |doi= 10.1074/jbc.M407708200

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