ATP1B1

ATP1B1

ATPase, Na+/K+ transporting, beta 1 polypeptide, also known as ATP1B1, is a human gene.cite web | title = Entrez Gene: ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=481| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=481| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na,K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=
*cite journal | author=Oakey RJ, Watson ML, Seldin MF |title=Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA. |journal=Hum. Mol. Genet. |volume=1 |issue= 8 |pages= 613–20 |year= 1993 |pmid= 1301170 |doi=
*cite journal | author=Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R |title=Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. |journal=J. Biol. Chem. |volume=264 |issue= 8 |pages= 4613–8 |year= 1989 |pmid= 2538450 |doi=
*cite journal | author=Ushkaryov YuA , Monastyrskaya GS, Broude NE, "et al." |title=Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene. |journal=FEBS Lett. |volume=257 |issue= 2 |pages= 439–42 |year= 1990 |pmid= 2555225 |doi=
*cite journal | author=Lane LK, Shull MM, Whitmer KR, Lingrel JB |title=Characterization of two genes for the human Na,K-ATPase beta subunit. |journal=Genomics |volume=5 |issue= 3 |pages= 445–53 |year= 1990 |pmid= 2559024 |doi=
*cite journal | author=Yang-Feng TL, Schneider JW, Lindgren V, "et al." |title=Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. |journal=Genomics |volume=2 |issue= 2 |pages= 128–38 |year= 1988 |pmid= 2842249 |doi=
*cite journal | author=Sverdlov ED, Broude NE, Sverdlov VE, "et al." |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129–33 |year= 1987 |pmid= 2887455 |doi=
*cite journal | author=Kawakami K, Nojima H, Ohta T, Nagano K |title=Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit. |journal=Nucleic Acids Res. |volume=14 |issue= 7 |pages= 2833–44 |year= 1986 |pmid= 3008098 |doi=
*cite journal | author=Coca-Prados M, Fernández-Cabezudo MJ, Sánchez-Torres J, "et al." |title=Cell-specific expression of the human Na+,K(+)-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=36 |issue= 13 |pages= 2717–28 |year= 1996 |pmid= 7499094 |doi=
*cite journal | author=Ruiz A, Bhat SP, Bok D |title=Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium. |journal=Gene |volume=155 |issue= 2 |pages= 179–84 |year= 1995 |pmid= 7536695 |doi=
*cite journal | author=Mobasheri A, Oukrif D, Dawodu SP, "et al." |title=Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization. |journal=Histol. Histopathol. |volume=16 |issue= 1 |pages= 141–54 |year= 2001 |pmid= 11193188 |doi=
*cite journal | author=Gamaleĭ IA, Polozov IuS, Aksenov ND, "et al." |title= [Cell cycle and formation of active form of oxygen in rodent fibroblasts] |journal=Tsitologiia |volume=43 |issue= 6 |pages= 602–12 |year= 2001 |pmid= 11534180 |doi=
*cite journal | author=Béguin P, Crambert G, Monnet-Tschudi F, "et al." |title=FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3264–73 |year= 2002 |pmid= 12093728 |doi= 10.1093/emboj/cdf330
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827
*cite journal | author=Fuller W, Eaton P, Bell JR, Shattock MJ |title=Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. |journal=FASEB J. |volume=18 |issue= 1 |pages= 197–9 |year= 2004 |pmid= 14597563 |doi= 10.1096/fj.03-0213fje
*cite journal | author=Li J, Codina J, Petroske E, "et al." |title=The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function. |journal=Kidney Int. |volume=65 |issue= 4 |pages= 1301–10 |year= 2004 |pmid= 15086469 |doi= 10.1111/j.1523-1755.2004.00507.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wickham L, Benjannet S, Marcinkiewicz E, "et al." |title=Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. |journal=J. Neurochem. |volume=92 |issue= 1 |pages= 93–102 |year= 2005 |pmid= 15606899 |doi= 10.1111/j.1471-4159.2004.02840.x

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