PRDM1

PR domain containing 1, with ZNF domain, also known as PRDM1, is a human gene.cite web | title = Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=639| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.cite web | title = Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=639| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Keller AD, Maniatis T |title=Identification and characterization of a novel repressor of beta-interferon gene expression. |journal=Genes Dev. |volume=5 |issue= 5 |pages= 868–79 |year= 1991 |pmid= 1851123 |doi=
*cite journal | author=Huang S |title=Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1. |journal=Cell |volume=78 |issue= 1 |pages= 9 |year= 1994 |pmid= 8033216 |doi=
*cite journal | author=Turner CA, Mack DH, Davis MM |title=Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. |journal=Cell |volume=77 |issue= 2 |pages= 297–306 |year= 1994 |pmid= 8168136 |doi=
*cite journal | author=Mock BA, Liu L, LePaslier D, Huang S |title=The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10. |journal=Genomics |volume=37 |issue= 1 |pages= 24–8 |year= 1997 |pmid= 8921366 |doi=
*cite journal | author=Ren B, Chee KJ, Kim TH, Maniatis T |title=PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 125–37 |year= 1999 |pmid= 9887105 |doi=
*cite journal | author=Angelin-Duclos C, Cattoretti G, Lin KI, Calame K |title=Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. |journal=J. Immunol. |volume=165 |issue= 10 |pages= 5462–71 |year= 2000 |pmid= 11067898 |doi=
*cite journal | author=Gupta S, Anthony A, Pernis AB |title=Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6104–11 |year= 2001 |pmid= 11342629 |doi=
*cite journal | author=Medina F, Segundo C, Campos-Caro A, "et al." |title=The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression. |journal=Blood |volume=99 |issue= 6 |pages= 2154–61 |year= 2002 |pmid= 11877292 |doi=
*cite journal | author=Shaffer AL, Lin KI, Kuo TC, "et al." |title=Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. |journal=Immunity |volume=17 |issue= 1 |pages= 51–62 |year= 2002 |pmid= 12150891 |doi=
*cite journal | author=Vasanwala FH, Kusam S, Toney LM, Dent AL |title=Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 1922–9 |year= 2002 |pmid= 12165517 |doi=
*cite journal | author=Borson ND, Lacy MQ, Wettstein PJ |title=Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma. |journal=Blood |volume=100 |issue= 13 |pages= 4629–39 |year= 2003 |pmid= 12453881 |doi= 10.1182/blood.V100.13.4629
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Györy I, Fejér G, Ghosh N, "et al." |title=Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. |journal=J. Immunol. |volume=170 |issue= 6 |pages= 3125–33 |year= 2003 |pmid= 12626569 |doi=
*cite journal | author=Gyory I, Wu J, Fejér G, "et al." |title=PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. |journal=Nat. Immunol. |volume=5 |issue= 3 |pages= 299–308 |year= 2004 |pmid= 14985713 |doi= 10.1038/ni1046
*cite journal | author=Lotz C, Mutallib SA, Oehlrich N, "et al." |title=Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. |journal=J. Immunol. |volume=175 |issue= 2 |pages= 1301–9 |year= 2005 |pmid= 16002735 |doi=
*cite journal | author=Tam W, Gomez M, Chadburn A, "et al." |title=Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. |journal=Blood |volume=107 |issue= 10 |pages= 4090–100 |year= 2006 |pmid= 16424392 |doi= 10.1182/blood-2005-09-3778
*cite journal | author=Pasqualucci L, Compagno M, Houldsworth J, "et al." |title=Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. |journal=J. Exp. Med. |volume=203 |issue= 2 |pages= 311–7 |year= 2006 |pmid= 16492805 |doi= 10.1084/jem.20052204
*cite journal | author=González-García I, Ocaña E, Jiménez-Gómez G, "et al." |title=Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells. |journal=J. Immunol. |volume=176 |issue= 7 |pages= 4042–50 |year= 2006 |pmid= 16547239 |doi=
*cite journal | author=Garcia JF, Roncador G, García JF, "et al." |title=PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma. |journal=Haematologica |volume=91 |issue= 4 |pages= 467–74 |year= 2006 |pmid= 16585013 |doi=
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes