CACNA2D2

Calcium channel, voltage-dependent, alpha 2/delta subunit 2, also known as CACNA2D2, is a human gene.cite web | title = Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9254| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9254| accessdate = ]

ee also

* Voltage-dependent calcium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Donato R, Page KM, Koch D, "et al." |title=The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. |journal=J. Neurosci. |volume=26 |issue= 48 |pages= 12576-86 |year= 2006 |pmid= 17135419 |doi= 10.1523/JNEUROSCI.3080-06.2006
*cite journal | author=Carboni GL, Gao B, Nishizaki M, "et al." |title=CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. |journal=Oncogene |volume=22 |issue= 4 |pages= 615-26 |year= 2003 |pmid= 12555074 |doi= 10.1038/sj.onc.1206134
*cite journal | author=Honorio S, Gordon K, MacCartney D, "et al." |title=Identification of a single nucleotide polymorphism in the human alpha 2 delta 2 calcium channel subunit gene. |journal=Mol. Cell. Probes |volume=15 |issue= 6 |pages= 391-3 |year= 2002 |pmid= 11851383 |doi= 10.1006/mcpr.2001.0382
*cite journal | author=Angeloni D, Duh FM, Wei MF, "et al." |title=A G-to-A single nucleotide polymorphism in intron 2 of the human CACNA2D2 gene that maps at 3p21.3. |journal=Mol. Cell. Probes |volume=15 |issue= 2 |pages= 125-7 |year= 2001 |pmid= 11292331 |doi= 10.1006/mcpr.2000.0341
*cite journal | author=Lerman MI, Minna JD |title=The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 6116-33 |year= 2000 |pmid= 11085536 |doi=
*cite journal | author=Gao B, Sekido Y, Maximov A, "et al." |title=Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2). |journal=J. Biol. Chem. |volume=275 |issue= 16 |pages= 12237-42 |year= 2000 |pmid= 10766861 |doi=
*cite journal | author=Hobom M, Dai S, Marais E, "et al." |title=Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit. |journal=Eur. J. Neurosci. |volume=12 |issue= 4 |pages= 1217-26 |year= 2000 |pmid= 10762351 |doi=
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi=

External links

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