KCNJ10

Potassium inwardly-rectifying channel, subfamily J, member 10, also known as KCNJ10 or K_ir4.1, is a human gene.cite web | title = Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3766| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.cite web | title = Entrez Gene: KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3766| accessdate = ]

ee also

* Inward-rectifier potassium ion channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kubo Y, Adelman JP, Clapham DE, "et al." |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11
*cite journal | author=Shuck ME, Piser TM, Bock JH, "et al." |title=Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 586–93 |year= 1997 |pmid= 8995301 |doi=
*cite journal | author=Horio Y, Hibino H, Inanobe A, "et al." |title=Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90. |journal=J. Biol. Chem. |volume=272 |issue= 20 |pages= 12885–8 |year= 1997 |pmid= 9148889 |doi=
*cite journal | author=Tada Y, Horio Y, Takumi T, "et al." |title=Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1. |journal=Genomics |volume=45 |issue= 3 |pages= 629–30 |year= 1998 |pmid= 9367690 |doi= 10.1006/geno.1997.4957
*cite journal | author=Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ |title=CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 161–72 |year= 1998 |pmid= 9647694 |doi= 10.1006/mcne.1998.0679
*cite journal | author=Kurschner C, Yuzaki M |title=Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. |journal=J. Neurosci. |volume=19 |issue= 18 |pages= 7770–80 |year= 1999 |pmid= 10479680 |doi=
*cite journal | author=Schoots O, Wilson JM, Ethier N, "et al." |title=Co-expression of human Kir3 subunits can yield channels with different functional properties. |journal=Cell. Signal. |volume=11 |issue= 12 |pages= 871–83 |year= 2000 |pmid= 10659995 |doi=
*cite journal | author=Fujita A, Horio Y, Higashi K, "et al." |title=Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump. |journal=J. Physiol. (Lond.) |volume=540 |issue= Pt 1 |pages= 85–92 |year= 2002 |pmid= 11927671 |doi=
*cite journal | author=Farook VS, Hanson RL, Wolford JK, "et al." |title=Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians. |journal=Diabetes |volume=51 |issue= 11 |pages= 3342–6 |year= 2002 |pmid= 12401729 |doi=
*cite journal | author=Konstas AA, Korbmacher C, Tucker SJ |title=Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 4 |pages= C910–7 |year= 2003 |pmid= 12456399 |doi= 10.1152/ajpcell.00479.2002
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Casamassima M, D'Adamo MC, Pessia M, Tucker SJ |title=Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43533–40 |year= 2003 |pmid= 12923169 |doi= 10.1074/jbc.M306596200
*cite journal | author=Buono RJ, Lohoff FW, Sander T, "et al." |title=Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. |journal=Epilepsy Res. |volume=58 |issue= 2-3 |pages= 175–83 |year= 2004 |pmid= 15120748 |doi= 10.1016/j.eplepsyres.2004.02.003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lenzen KP, Heils A, Lorenz S, "et al." |title=Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. |journal=Epilepsy Res. |volume=63 |issue= 2-3 |pages= 113–8 |year= 2005 |pmid= 15725393 |doi= 10.1016/j.eplepsyres.2005.01.002
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Huang C, Sindic A, Hill CE, "et al." |title=Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. |journal=Am. J. Physiol. Renal Physiol. |volume=292 |issue= 3 |pages= F1073–81 |year= 2007 |pmid= 17122384 |doi= 10.1152/ajprenal.00269.2006

External links

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